Effect of fractional exhaled carbon monoxide on patients with sleep apnea-hypopnea syndrome and its mechanism.

Efecto de la fracción exhalada de monóxido de carbono en pacientes con síndrome de apnea-hipopnea del sueño y su mecanismo.

• Quanlin Jia Shanxi Changzhi Second People’s Hospital, China. https://orcid.org/0000-0002-4875-4798
• Li Guo Shanxi Changzhi Second People’s Hospital, China. https://orcid.org/0000-0002-2529-7643
• Xinhua Zheng Shanxi Changzhi Second People’s Hospital, China. https://orcid.org/0000-0003-3171-173X
• Guangwei Li Shanxi Changzhi Second People’s Hospital, China. https://orcid.org/0000-0002-9995-1695
• Lu Liu Shanxi Changzhi Second People’s Hospital, Changzhi, China. https://orcid.org/0000-0002-7701-7519

DOI: https://doi.org/10.54817/IC.v65n1a09

Keywords: Sleep-disordered breathing, fractional exhaled carbon monoxide, eosinophils, erythrocyte sedimentation rate, C-reactive protein

Abstract

Sleep-disordered breathing (SDB) is a common sleep disorder associated with chronic airway inflammation and lung function impairment. This article aimed to investigate the fractional exhaled carbon monoxide (FeCO) expression level in obstructive sleep apnea-hypopnea syndrome (OSAHS) and its correlation with disease indicators. Subjects with OSAHS, asthma, chronic obstructive pulmonary disease (COPD), and healthy subjects were selected to collect clinical data. FeCO concentration, eosinophil (Eos), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), FEV 1, and FEV 1 /FVC were measured. The Pearson correlation coefficient and receiver operating characteristic (ROC) curve were used for statistical analysis. The FeCO concentration, Eos count, ESR and CRP levels, and lung function in the OSAHS group were higher than the healthy and COPD groups (p<0.05) and slightly lower than the asthma group. FeCO was positively correlated with Eos, ESR, and CRP (p<0.05), but there was no apparent correlation between FeCO and lung function. FeCO has a high sensitivity and specificity in the diagnosis of OSAHS. There is chronic airway inflammation and systemic inflammation in patients with OSAHS. Lung function impairment in patients with OSAHS is mild, but some limitations remain. FeCO may be an auxiliary diagnostic index particularly valuable in diagnosing OSAHS.

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