Considerations on the new treatments for hemophilia.
Abstract
The quality of life of the hemophilic patient, has improved significantly improved since the treatment with factors VIII or IX concentrates started being applied. It was improved further with the use of recombinant and extended half-life factor VIII and factor IX concentrates. Today, new therapies are emerging, that address the need of frequent intravenous injections (mainly by the transference of a normal gene in the human hepatocyte) and the presence of antibodies anti factors VIII or IX, or target the natural anticoagulant factors. All of these new treatments will be expensive and probably not affordable by the poor countries of the world. In Venezuela, the average patient with hemophilia, has great difficulty obtaining human factor concentrates and has to rely on old treatments such as fresh frozen plasma and cryoprecipitates.
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