Association between food craving and taste genes in people with obesity.
Asociación entre el “food craving” y los genes del gusto en personas con obesidad
Keywords:
food craving, FCQ-Trate & FCQ-State, gene expression, obesity
Abstract
Food craving (FC) is an uncontrollable desire to eat specific foods, and it is activated during the withdrawal phase of eating foods, com-monly sugary, salty or fatty. Comorbidity has been found with obesity (OB) and eating behavior disorders, as well as being a negative factor for adherence to OB treatments. Trait and State Food-Cravings Questionnaires, are validated instru-ments, that measure trait and state; both are reliable, with high internal consis-tency (ɑ> 0.90). The objective, was to analyze differences in normal weight and obese subjects, in scores of the FCQ Trait and State, and their correlation with gene expression DRD2, TAS1R2, TAS1R3 and TAS2R43. It was a correlational, cross-sectional study of cases and controls, non-probabilistic sampling, and at convenience; n= 40 adults, both sexes between 18-45 years, 20 normal weight and 20 obese, from Mexico City and the State of Mexico. BMI, gene expression and FC were evaluated. Significant differences were found (p <0.05) in rela-tive expression of TAS1R2, and positive correlation between FCQ and TAS1R2 expression in obese; in turn we found that FCQ-T and FCQ-S predict gene ex-pression of TAS1R2 and TAS2R43 in men, and in women of TAS1R2, TAS2R43 and DRD2. This research offers new perspectives to understand the association between FC with the sweet taste receptor (TAS1R2), evidencing the link with molecular components, which together influence the explanation of the devel-opment of addiction to sugary foods in OB.
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References
Tiggemann M, Kemps E. The phenomenology of food cravings: the role of mental imagery. Appetite. 2005;45(3):305-313. doi: 10.1016/j.appet.2005.06.004.
López Durán A, Becoña Iglesias E. El craving en personas dependientes de la cocaína. An Psicol 2006; 22(2):205-211. Disponible en: https://revistas.um.es/analesps/ article/view/25811
Franssen S, Jansen A, Schyns G, van den Akker K, Roefs A. Neural correlates of food cue exposure intervention for obesity: a case-series approach. Front Behav Neurosci 2020; 21;14:46. doi: 10.3389/ fnbeh.2020.00046.
Hallam J, Boswell RG, DeVito EE, Kober H. Gender related differences in food craving and obesity. Yale J Biol Med 2016 27;89(2):161-173.
Yeh J, Trang A,Henning S, Wilhalme H, Carpenter C, Herber D, Li Z. Food cravings, food addiction, and a dopamine-resistant (DRD2 A1) receptor polymorphism in Asian American college students. Asia Pac J Clin Nutr 2016;25(2):424-429. doi: 10.6133/apjcn.102015.05.
Lafay L, Thomas F, Mennen L, Charles MA, Eschwege E, Borys JM, Basdevant A; Fleurbaix Laventie Ville Santé Study Group. Gender differences in the relation between food cravings and mood in an adult community: Results from the fleurbaix la ventie ville santé study. Int J Eat Disord 2001;29(2):195-204. doi: 10.1002/1098-108x(200103)29:2<195::aid-eat1009>3.0.co;2-n.
McVay MA, Copeland AL, Newman HS, Geiselman PJ. Food cravings and food cue responding across the menstrual cycle in a non-eating disordered sample. Appetite 2012; 59(2):591-600. doi: 10.1016/j.appet.2012.07.011.
Potenza MN, Grilo CM. How relevant is food craving to obesity and Its treatment? Front Psychiatry 2014; 19 (5):164. doi: 10.3389/fpsyt.2014.00164.
Ben Shoshan Galeczki Y, Niv MY. Structure based screening for discovery of sweet compounds. Food Chem 2020; 15; 315:126286. doi: 10.1016/j.foodchem.2020.126286.
Heianza Y, Qi L. Genediet interaction and precision nutrition in obesity. Int J Mol Sci 2017; 18(4):787. doi: 10.3390/ijms18040787.
Zheng Y, Li Y, Huang T, Cheng HL, Campos H, Qi L. Sugar sweetened beverage in-take, chromosome 9p21 variants, and risk of myocardial infarction in Hispanics. Am J Clin Nutr 2016;103(4):1179-1184. doi: 10.3945/ajcn.115.107177.
Yilmaz Z, Davis C, Loxton NJ, Kaplan AS, Levitan RD, Carter JC, Kennedy JL. Association between MC4R rs17782313 polymorphism and overeating behaviors. Int J Obes (Lond) 2015;39(1):114-120. doi: 10.1038/ijo.2014.79.
Bachmanov AA, Beauchamp GK. Taste receptor genes. Annu Rev Nutr 2007;27:389-414. doi: 10.1146/annurev. nutr.26.061505.111329.
Bachmanov AA, Bosak NP, Lin C, Matsumoto I, Ohmoto M, Reed DR, Nelson TM. Genetics of taste receptors. Curr Pharm Des 2014;20(16):2669-2683. doi: 10.2174/13816128113199990566.
Chen Q, Alarcon S, Tharp A, Ahmed O, Estrella N, Greene T, Rucker J, Breslin P. Perceptual variation in umami taste and polymorphisms in TAS1R taste receptor genes. Am J Clin Nutr 2009;90(3):770S-779S. doi: 10.3945/ajcn.2009.27462N
Kim J, Ren D, Reverter A, Roura E. A regulatory gene network related to the porcine umami taste receptor (TAS1R1/TAS1R3). Anim Genet 2016;47(1):114-119. doi: 10.1111/age.12374.
San Gabriel A, Uneyama H, Yoshie S, ToriiK. Cloning and characterization of a novel mGluR1 variant from vallate papillae that functions as a receptor for L-glutamate stimuli. Chem Senses 2005;30 (Suppl 1):i25- 26. doi: 10.1093/chemse/bjh095.
Schier LA, Spector AC. The functional and neurobiological properties of bad taste. Physiol Rev 2019; 99(1):605-663. doi: 10.1152/physrev.00044.2017.
Huang T, Zheng Y, Hruby A, Williamson D, Bray G, Shen Y, Sacks F, Qi L. Dietary protein modifies the effect of the MC4R genotype on 2-year changes in appetite and food craving: the POUNDS Lost Trial. J Nutr 2017;147(3):439-444. doi: 10.3945/ jn.116.242958.
Perna S, Riva A, Nicosanti G, Carrai M, Barale R, Vigo B, Allegrini P, Rondanelli M. Association of the bitter taste receptor gene TAS2R38(polymorphism RS713598) with sensory responsiveness, food preferences, biochemical parameters and body composition markers. A cross-sectional study in Italy. Int J Food Sci Nutr 2017; 24:1-8. doi: 10.1080/09637486.2017.1353954.
Ramos Lopez O, Panduro A, Martinez Lopez E, Roman S. Sweet taste receptor TAS1R2 polymorphism (Val191Val) is associated with a higher carbohydrate intake and hypertriglyceridemia among the population of West Mexico. Nutrients 2016; 19;8(2):101. doi: 10.3390/nu8020101.
Melo S, Agnes G, Votolo M, Mattevi V, Campagnolo P, Almeida S. Evaluation of the association between the TAS1R2 and TAS1R3 variants and food intake and nutritional status in children. Genet Mol Biol 2017;40(2):415-420. doi: 10.1590/1678-4685-GMB-2016-0205.
Genis Mendoza A, Nicolini H, Tovilla Zárate CA, López Narváez ML, González Castro TB. Association between the feeding behavior factors and the expression of DRD2 gene: a study of Mexican monozygotic twins. Gac Med Mex 2016;152(3):329-33.
Marín Soto MD, León CV, Pérez Vielma NM, Castillo Ramírez M, Miliar García Á, Murillo Tovar MM, Méndez Peña B, Aguilera Sosa VR. Intense craving for appetizing foods: validation and standardization of the Food Cravings Questionnaire Trait in Mexico. Gac Med Mex 2020;156(1):27-33. doi: 10.24875/GMM.19005358.
Han P, Keast RSJ, Roura E. Salivary leptin and TAS1R2/TAS1R3 polymorghisms are related to sweet taste sensitivy and carbo-hydrate intake from a buffet meal in healthy young adults. Br J Nutr 2017;118(10):763- 770. doi: 10.1017/S0007114517002872.
Abedini A, Derk J, Schmidt AM. The receptor for advanced glycation endproducts is a mediator of toxicity by IAPP and other proteotoxic aggregates: Establishing and exploiting common ground for novel amyloidosis therapies. Protein Sci 2018;27(7):1166-1180. doi: 10.1002/ pro.3425. PMID: 29664151.
Abedini A, Derk J, Schmidt AM. The receptor for advanced glycation endpro ducts is a mediator of toxicity by IAPP and other proteotoxic aggregates: Establishing and exploiting on round for novel amyloidosis therapies. Protein Sci 2018;27(7):1166-1180. doi: 10.1002/pro.3425. PMID: 29664151.
Lytrivi M, Castell AL, Poitout V, Cnop M. Recent insights into mechanisms of β-cell lipo and glucolipotoxicity in Type 2 diabetes. J Mol Biol 2020 6;432(5):1514-1534. doi: 10.1016/j.jmb.2019.09.016.
Howles PN. Cholesterol absorption and metabolism. Methods Mol Biol 2016;1438:177- 197. doi: 10.1007/978-1-4939-3661-8_11.
Muñoz MÁ, Sanjuan R, Fernández Santaella MC, Vila J, Montoya P. Aspectos neuropsicológicos del craving por la nicotina Adicciones 2011;23(2):111-123.
Lennerz B, Lennerz JK. Food addiction, high-glycemic-index carbohydrates, and obesity. Clin Chem 2018;64(1):64-71. doi: 10.1373/clinchem.2017.273532.
López Durán A, Becoña Iglesias E. El craving en personas dependientes de la cocaína. An Psicol 2006; 22(2):205-211. Disponible en: https://revistas.um.es/analesps/ article/view/25811
Franssen S, Jansen A, Schyns G, van den Akker K, Roefs A. Neural correlates of food cue exposure intervention for obesity: a case-series approach. Front Behav Neurosci 2020; 21;14:46. doi: 10.3389/ fnbeh.2020.00046.
Hallam J, Boswell RG, DeVito EE, Kober H. Gender related differences in food craving and obesity. Yale J Biol Med 2016 27;89(2):161-173.
Yeh J, Trang A,Henning S, Wilhalme H, Carpenter C, Herber D, Li Z. Food cravings, food addiction, and a dopamine-resistant (DRD2 A1) receptor polymorphism in Asian American college students. Asia Pac J Clin Nutr 2016;25(2):424-429. doi: 10.6133/apjcn.102015.05.
Lafay L, Thomas F, Mennen L, Charles MA, Eschwege E, Borys JM, Basdevant A; Fleurbaix Laventie Ville Santé Study Group. Gender differences in the relation between food cravings and mood in an adult community: Results from the fleurbaix la ventie ville santé study. Int J Eat Disord 2001;29(2):195-204. doi: 10.1002/1098-108x(200103)29:2<195::aid-eat1009>3.0.co;2-n.
McVay MA, Copeland AL, Newman HS, Geiselman PJ. Food cravings and food cue responding across the menstrual cycle in a non-eating disordered sample. Appetite 2012; 59(2):591-600. doi: 10.1016/j.appet.2012.07.011.
Potenza MN, Grilo CM. How relevant is food craving to obesity and Its treatment? Front Psychiatry 2014; 19 (5):164. doi: 10.3389/fpsyt.2014.00164.
Ben Shoshan Galeczki Y, Niv MY. Structure based screening for discovery of sweet compounds. Food Chem 2020; 15; 315:126286. doi: 10.1016/j.foodchem.2020.126286.
Heianza Y, Qi L. Genediet interaction and precision nutrition in obesity. Int J Mol Sci 2017; 18(4):787. doi: 10.3390/ijms18040787.
Zheng Y, Li Y, Huang T, Cheng HL, Campos H, Qi L. Sugar sweetened beverage in-take, chromosome 9p21 variants, and risk of myocardial infarction in Hispanics. Am J Clin Nutr 2016;103(4):1179-1184. doi: 10.3945/ajcn.115.107177.
Yilmaz Z, Davis C, Loxton NJ, Kaplan AS, Levitan RD, Carter JC, Kennedy JL. Association between MC4R rs17782313 polymorphism and overeating behaviors. Int J Obes (Lond) 2015;39(1):114-120. doi: 10.1038/ijo.2014.79.
Bachmanov AA, Beauchamp GK. Taste receptor genes. Annu Rev Nutr 2007;27:389-414. doi: 10.1146/annurev. nutr.26.061505.111329.
Bachmanov AA, Bosak NP, Lin C, Matsumoto I, Ohmoto M, Reed DR, Nelson TM. Genetics of taste receptors. Curr Pharm Des 2014;20(16):2669-2683. doi: 10.2174/13816128113199990566.
Chen Q, Alarcon S, Tharp A, Ahmed O, Estrella N, Greene T, Rucker J, Breslin P. Perceptual variation in umami taste and polymorphisms in TAS1R taste receptor genes. Am J Clin Nutr 2009;90(3):770S-779S. doi: 10.3945/ajcn.2009.27462N
Kim J, Ren D, Reverter A, Roura E. A regulatory gene network related to the porcine umami taste receptor (TAS1R1/TAS1R3). Anim Genet 2016;47(1):114-119. doi: 10.1111/age.12374.
San Gabriel A, Uneyama H, Yoshie S, ToriiK. Cloning and characterization of a novel mGluR1 variant from vallate papillae that functions as a receptor for L-glutamate stimuli. Chem Senses 2005;30 (Suppl 1):i25- 26. doi: 10.1093/chemse/bjh095.
Schier LA, Spector AC. The functional and neurobiological properties of bad taste. Physiol Rev 2019; 99(1):605-663. doi: 10.1152/physrev.00044.2017.
Huang T, Zheng Y, Hruby A, Williamson D, Bray G, Shen Y, Sacks F, Qi L. Dietary protein modifies the effect of the MC4R genotype on 2-year changes in appetite and food craving: the POUNDS Lost Trial. J Nutr 2017;147(3):439-444. doi: 10.3945/ jn.116.242958.
Perna S, Riva A, Nicosanti G, Carrai M, Barale R, Vigo B, Allegrini P, Rondanelli M. Association of the bitter taste receptor gene TAS2R38(polymorphism RS713598) with sensory responsiveness, food preferences, biochemical parameters and body composition markers. A cross-sectional study in Italy. Int J Food Sci Nutr 2017; 24:1-8. doi: 10.1080/09637486.2017.1353954.
Ramos Lopez O, Panduro A, Martinez Lopez E, Roman S. Sweet taste receptor TAS1R2 polymorphism (Val191Val) is associated with a higher carbohydrate intake and hypertriglyceridemia among the population of West Mexico. Nutrients 2016; 19;8(2):101. doi: 10.3390/nu8020101.
Melo S, Agnes G, Votolo M, Mattevi V, Campagnolo P, Almeida S. Evaluation of the association between the TAS1R2 and TAS1R3 variants and food intake and nutritional status in children. Genet Mol Biol 2017;40(2):415-420. doi: 10.1590/1678-4685-GMB-2016-0205.
Genis Mendoza A, Nicolini H, Tovilla Zárate CA, López Narváez ML, González Castro TB. Association between the feeding behavior factors and the expression of DRD2 gene: a study of Mexican monozygotic twins. Gac Med Mex 2016;152(3):329-33.
Marín Soto MD, León CV, Pérez Vielma NM, Castillo Ramírez M, Miliar García Á, Murillo Tovar MM, Méndez Peña B, Aguilera Sosa VR. Intense craving for appetizing foods: validation and standardization of the Food Cravings Questionnaire Trait in Mexico. Gac Med Mex 2020;156(1):27-33. doi: 10.24875/GMM.19005358.
Han P, Keast RSJ, Roura E. Salivary leptin and TAS1R2/TAS1R3 polymorghisms are related to sweet taste sensitivy and carbo-hydrate intake from a buffet meal in healthy young adults. Br J Nutr 2017;118(10):763- 770. doi: 10.1017/S0007114517002872.
Abedini A, Derk J, Schmidt AM. The receptor for advanced glycation endproducts is a mediator of toxicity by IAPP and other proteotoxic aggregates: Establishing and exploiting common ground for novel amyloidosis therapies. Protein Sci 2018;27(7):1166-1180. doi: 10.1002/ pro.3425. PMID: 29664151.
Abedini A, Derk J, Schmidt AM. The receptor for advanced glycation endpro ducts is a mediator of toxicity by IAPP and other proteotoxic aggregates: Establishing and exploiting on round for novel amyloidosis therapies. Protein Sci 2018;27(7):1166-1180. doi: 10.1002/pro.3425. PMID: 29664151.
Lytrivi M, Castell AL, Poitout V, Cnop M. Recent insights into mechanisms of β-cell lipo and glucolipotoxicity in Type 2 diabetes. J Mol Biol 2020 6;432(5):1514-1534. doi: 10.1016/j.jmb.2019.09.016.
Howles PN. Cholesterol absorption and metabolism. Methods Mol Biol 2016;1438:177- 197. doi: 10.1007/978-1-4939-3661-8_11.
Muñoz MÁ, Sanjuan R, Fernández Santaella MC, Vila J, Montoya P. Aspectos neuropsicológicos del craving por la nicotina Adicciones 2011;23(2):111-123.
Lennerz B, Lennerz JK. Food addiction, high-glycemic-index carbohydrates, and obesity. Clin Chem 2018;64(1):64-71. doi: 10.1373/clinchem.2017.273532.
Published
2021-06-10
How to Cite
Marín-Soto, M. D., Miliar-García, A., Gómez-López, M., González-Mundo, I., & Aguilera-Sosa, V. R. (2021). Association between food craving and taste genes in people with obesity.: Asociación entre el “food craving” y los genes del gusto en personas con obesidad. Investigación Clínica, 62(2), 119-131. https://doi.org/10.22209/IC.v62n2a03
Section
Original Works
