Effect of fractional exhaled carbon monoxide on patients with sleep apnea-hypopnea syndrome and its mechanism.
Efecto de la fracción exhalada de monóxido de carbono en pacientes con síndrome de apnea-hipopnea del sueño y su mecanismo.
Palabras clave:
Respiración alterada durante el sueño, fracción de monóxido de carbono exhalado, eosinófilos, velocidad de sedimentación globular, proteína C-reactiva
Resumen
Los trastornos respiratorios del sueño (TRS) son un desorden del sueño común asociado con inflamación crónica de las vías respiratorias y deterioro de la función pulmonar. Este artículo tuvo como objetivo investigar el nivel fraccional de exhalación de monóxido de carbono (FeCO) en el síndrome de apnea- hipopnea obstructiva del sueño (SAHOS) y su correlación con los indicadores de la enfermedad. Se seleccionaron sujetos con SAHOS, asma, enfermedad pulmonar obstructiva crónica (EPOC) y sujetos sanos para recopilar datos clínicos. Se midieron la concentración de FeCO, eosinófilos (Eos), velocidad de sedimentación globular (ESR), proteína C reactiva (PCR), FEV1 y FEV1/FVC. Para el análisis estadístico se utilizaron el coeficiente de correlación de Pearson y la curva de características operativas del receptor (ROC). La concentración de FeCO, el recuento de Eos, los niveles de VSG y PCR y la función pulmonar en el grupo de OSAHS fueron claramente más altos que en los grupos sanos y con EPOC (p<0,05) y ligeramente más bajos que en el grupo de asma. FeCO se correlacionó positivamente con Eos, ESR y CRP (p<0,05), pero no hubo correlación aparente entre FeCO y la función pulmonar. El FeCO mostró una alta sensibilidad y especificidad en el diagnóstico del SAHOS. Existe inflamación crónica de las vías respiratorias e inflamación sistémica en pacientes con SAHOS. El deterioro de la función pulmonar en pacientes con SAHOS es leve, pero persisten algunas limitaciones. El FeCO puede ser un índice diagnóstico auxiliar particularmente valioso en el diagnóstico del SAHOS.
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Citas
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Iannella G, Magliulo G, Greco A, de Vincentiis M, Ralli M, Maniaci A, Pace A, Vicini C. Obstructive sleep apnea syndrome: from symptoms to treatment. Int J Environ Res Public Health 2022;19(4):2459(1-3). https://doi.org/10.3390/ijerph19042459.
Malhotra A, Ayappa I, Ayas N, Collop N, Kirsch D, Mcardle N, Mehra R, Pack AI, Punjabi N, White DP, Gottlieb DJ. Metrics of sleep apnea severity: beyond the apnea-hypopnea index. Sleep 2021;44(7) zsab030(1-16). https://doi.org/10.1093/sleep/zsab030.
Zhang L, Ou X, Zhu T, Lv X. Beneficial effects of estrogens in obstructive sleep apnea-hypopnea syndrome. Sleep Breath 2020;24(1):7-13. https://doi.org/10.1007/s11325-019-01896-2
Ya Y, Shi Z, Xue X, Ling T. Comparison of the diagnostic value of capsule endoscopy in two positions for esophageal lesions in the elderly. Acta Medica Mediterr 2019;35(6):3389-3394. https://doi.org/10.3892%2Fetm.2018.5864.
Jiao X, Zou J, Meng L, Liu S, Guan J, Yi H, Yin S. Risk factors for non-positional obstructive sleep apnea-hypopnea syndrome. Sleep Breath 2022;26(2):675-680. https://doi.org/10.1007/s11325-021-02430-z.
Akkari M, Yildiz S, Marianowski R, Monteyrol PJ, Chalumeau F, Fayoux P, Leboulanger N, Franco P, Couloigner V, Mondain M. Role of the ENT specialist in the diagnosis of pediatric obstructive sleep apnea-hypopnea syndrome (POSAHS). Part 3: sleep recordings. Eur Ann Otorhinolaryngol Head Neck Dis 2020;137(5):405-410. https://doi.org/10.1016/j.anorl.2020.02.001.
Zhou J, Wu Z, Xu H, Gao L, Wang C, Zheng F, Yao Y. Nano-Carbon-Based application of parecoxib sodium combined with hydromorphone in preventing anesthesia hyperalgesia caused by remifentanil after thyroidectomy. Cell Mol Biol 2022;3:68(1-8). https://doi.org/10.14715/cmb/2022.68.3.24.
Zeng YM, Hu AK, Su HZ, Ko CY. A review of the association between oral bacterial flora and obstructive sleep apnea-hypopnea syndrome comorbid with cardiovascular disease. Sleep Breath 2020;24(4):1261-1266. https://doi.org/10.1007/s11325-019-01962-9.
Xie Z, Chai M, Gu W, Yuan H. Changes in fractional exhaled nitric oxide, exhaled carbon monoxide and pulmonary function during the acute attack, treatment and remission phases of pediatric asthma. Transl Pediatr 2020;9(6):784-794. https://doi.org/10.21037%2Ftp-20-351.
Herath P, Wimalasekera S, Amarasekara T, Fernando M, Turale S. Effect of cigarette smoking on smoking biomarkers, blood pressure and blood lipid levels among Sri Lankan male smokers. Postgrad Med J 2022;98(1165):848-854. https://doi.org/10.1136/postgradmedj-2021-141016.
Rizzi M, Radovanovic D, Airoldi A, Cristiano A, Frassanito F, Gaboardi P, Saad M, Atzeni F, Sarzi-Puttini P, Santus P. Rationale underlying the measurement of fractional exhaled nitric oxide in systemic sclerosis patients. Clin Exp Rheumatol 2019;37 Suppl 119(4):125-132. PMID:30873947.
Wang H, Wang X, Fei J, Li F, Han J, Qin X. MicroRNA-23B inhibits non-small cell lung cancer proliferation, invasion and migration via downregulation of RUNX2 and inhibition of Wnt/Β-catenin signaling pathway. J Biol Regul Homeost Agents 2020;34(3):825-835. https://doi.org/10.23812/20-11-a-34
Pan KT, Leonardi GS, Ucci M, Croxford B. Can exhaled carbon monoxide be used as a marker of exposure? A cross-sectional study in young adults. Int J Environ Res Public Health 2021;18(22):11893(1-13). https://doi.org/10.3390%2Fijerph182211893
Kis A, Meszaros M, Tarnoki DL, Tarnoki AD, Lazar Z, Horvath P, Kunos L, Bikov Exhaled carbon monoxide levels in obstructive sleep apnoea. Journal of breath research, (2019).13(3), 036012. https://doi.org/10.1088/1752-7163/ab231d.
Martinez D. Effects of aging on peripheral chemoreceptor CO2 response during sleep and wakefulness in healthy men. Respir Physiol Neurobiol 2008 ;162(2):138-43. https://doi.org/10.1016/j.resp.2008.05. 009
Wang Y, Qin M, Jin L, Liu S, Fan K, Yu S. Correlation between exhaled nitric oxide and carbon monoxide and allergic rhinitis. Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2020;34(11):1014-1018. https://doi.org/10.13201/j.issn.2096- 7993.2020.11.013.
Gaalema DE, Yant B, Khadanga S, Savage PD, Rengo JL, Ades PA. Carbon monoxide monitoring to objectively measure smoking status in cardiac rehabilitation. Health Psychol 2022;41(10):733-739. https://doi.org/10.1037/hea0001178.
Fan Z, Lu X, Long H, Li T, Zhang Y. The association of hemocyte profile and obstructive sleep apnea. J Clin Lab Anal 2019;33(2):e22680(1-7). https://doi.org/10.1002/jcla.22680.
Popadic V, Brajkovic M, Klasnja S, Milic N, Rajovic N, Lisulov DP, Divac A, Ivankovic T, Manojlovic A, Nikolic N, Memon L, Brankovic M, Popovic M, Sekulic A, Macut JB, Markovic O, Djurasevic S, Stojkovic M, Todorovic Z, Zdravkovic M. Correlation of dyslipidemia and inflammation with obstructive sleep apnea severity. Front Pharmacol 2022;13:897279(1-8). https://doi.org/10.3389%2Ffphar.2022.897279.
Yi M, Zhao W, Tan Y, Fei Q, Liu K, Chen Z, Zhang Y. The causal relationships between obstructive sleep apnea and elevated chemoreceptor CO2 CRP and TNF-α protein levels. Ann Med and wakefulness in healthy men. Respir Physiol Neurobiol 2008 ;162(2):138-43. https://doi.org/10.1016/j.resp.2008.05.009.
Chen TY, Kung YY, Lai H C, Lee LA, Jen IA, Chang HA, Liu CY, Kuo TBJ, Yang CCH. Prevalence and effects of sleep-disordered breathing on middle-aged patients with sedative-free generalized anxiety disorder: A prospective case-control study. Front Psychiatry 2023:13. https://doi.org/10.3389/fpsyt.2022.1067437.
Fitzgerald D, Laurent M, Funaro M, Harel A, DeAngelis T, Bangeranye C, Najjar S, Tabansky I, Stern J. Defining the role of T lymphocytes in the immunopathogenesis of neuromyelitis optica spectrum disorder. Discov Med 2020;29(157):91-102. PMID: 33002405. 2022;54(1):1578-1589. https://doi.org/10.1080/07853890.2022.2081873.
Zhao C, Qin M, Jin L, Lai J, Wang Y, Liu S, Yu S. Significance of exhaled nitric oxide and carbon monoxide in auxiliary diagnosis and evaluation of allergic rhinitis. Mediators Inflamm 2022;2022:2083057(1-10). https://doi.org/10.1155/2022/2083057.
Publicado
2024-02-15
Cómo citar
Jia, Q., Guo, L., Zheng, X., Li, G., & Liu, L. (2024). Effect of fractional exhaled carbon monoxide on patients with sleep apnea-hypopnea syndrome and its mechanism.: Efecto de la fracción exhalada de monóxido de carbono en pacientes con síndrome de apnea-hipopnea del sueño y su mecanismo. Investigación Clínica, 65(1), 99-108. https://doi.org/10.54817/IC.v65n1a09
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