Efficiency of the use of perfluorocarbon gas transport drugs for various forms of anemia in animals

• Sergej V. Votrin Sechenov First Moscow State Medical Univesity (Sechenov Univesity) http://orcid.org/0000-0003-1773-1662
• Sergej I. Vorobyev Sechenov First Moscow State Medical Univesity (Sechenov Univesity) Moscow, Russia http://orcid.org/0000-0003-1383-957X
• Sergey B. Bolevich Sechenov First Moscow State Medical Univesity (Sechenov Univesity) Moscow, Russia http://orcid.org/0000-0002-1574-477X
• Aleksandra S. Orlova Sechenov First Moscow State Medical University (Sechenov University) Moscow, Russia http://orcid.org/0000-0001-9725-7491
• Denis D. Gudanovich Institute for Emergency Medicine Moscow, Russia http://orcid.org/0000-0002-8014-1799

DOI: https://doi.org/10.46925//rdluz.32.03

Keywords: hypoxia, hemolysis, anemia, correction, erythrocyte mass, perfluorocarbon blood substitute, critical conditions

Abstract

Purpose: The purpose of the article is to determine the effectiveness of the use of perfluorocarbon gas vehicles in acute, severe anemia in animals caused by external blood loss and autoimmune intravascular hemolysis. Methodology: The effectiveness of the use of perfluorocarbon gas transport agents in acute, severe anemia in animals caused by external blood loss and autoimmune intravascular hemolysis was carried out based on the assessment of lethality in groups, biochemical criteria that were determined using an automatic biochemical blood analyzer and an assessment of hematocrit, which was determined using an automatic an analyzer of a general clinical analysis of blood with an impedance counting system. Results: The high efficiency of the use of perfluorocarbon gas transport drug - Perftoran in acute and severe anemia caused by external blood loss and autoimmune intravascular hemolysis was revealed on the basis of an assessment of the lethality of animals in groups in comparison with a blood preparation - donor erythrocyte mass. The lethality in the groups of animals that used the perfluorocarbon gas transport agent was significantly lower than that in the animals that used the erythrocyte mass, especially in acute and severe anemia caused by autoimmune intravascular hemolysis.

 

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