Effect of thiamine pyrophosphate on oxidative damage in the brain and heart of rats with experimentally induced occlusion of the common carotid artery.
Efecto del pirofosfato de tiamina sobre el daño oxidativo en el cerebro y el corazón de ratas con oclusión inducida experimentalmente de la arteria carótida común.
Palabras clave:
arteria carótida, ıschemia, oclusión, rata, reperfusión, pirofosfato de tiamina
Resumen
Se sabe que un aumento repentino del flujo sanguíneo cerebral (hiperperfusión) con la revascularización carotídea puede causar la alteración y daños de la barrera hematoencefálica. El objetivo de este estudio fue explorar los efectos protectores del pirofosfato de tiamina (TPP) contra los posibles daños cerebrales y cardíacos resultantes del pinzamiento y despinzamiento de la carótida en ratas. Los animales se dividieron en grupos de pinzamiento y despinzamiento de la carótida común (CCU), TPP + pinzamiento y despinzamiento de la carótida común (TCCU) y operación simulada (SG). El grupo TCCU recibió una inyección intraperitoneal (IP) de TPP a una dosis de 20 mg/kg una hora antes de la anestesia. Los grupos CCU y SG recibieron agua destilada como disolvente. La isquemia se indujo manteniendo los clips en posición cerrada durante 10 min. En el grupo SG solo se realizó una incisión subcutánea. Luego se retiraron los clips, se suturaron las incisiones y se mantuvo la reperfusión durante 6 horas. Posteriormente, los animales fueron sacrificados con altas dosis de anestesia y se extrajeron tejidos del corazón y del cerebro. El TPP suprimió significativamente el aumento de malondialdehído (MDA) inducido por I/R y la disminución de los niveles de glutatión total (tGSH) tanto en el tejido cerebral como en el cardíaco. El TPP impidió el aumento de los niveles de factor de necrosis tumoral alfa (TNF-α), interleucina 1β (IL -1β) e interleucina-6 (IL -6) en los tejidos del cerebro y del corazón. En el suero sanguíneo, el TPP suprimió el aumento de la troponina I (TP I) y la creatina quinasa-MB (CK-MB) inducido por I/R en la sangre. Se demostró que el TPP protege el cerebro y los tejidos cardíacos distantes contra el daño oxidativo e inflamatorio inducido por la I/R cerebral.
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Hsu JC, Tsai HL. Endovascular recanalization of common carotid artery Total occlusion: two case reports and literature review. CVIR Endovasc. 2020;3(1): 6. doi: 10.1186/s42155-020-0097-6.
Kragsterman B, Bergqvist D, Siegbahn A, Parsson H. Carotid endarterectomy induces the release of inflammatory markers and the activation of coagulation as measured in the jugular bulb. J Stroke Cerebrovasc. 2017;26(10): 2320-2328. doi: 10.1016/j.jstrokecerebrovas- dis.2017.05.020.
Cho HJ, Kim YJ, Lee JH, Choi JW, Moon WJ, Roh HG, Chun YI, Kim HY. Post-carotid stenting reperfusion injury with bloodbrain barrier disruption on gadoliniumen hanced FLAIR MRI. BMC Neurol. 2014;14: 178. doi: 10.1186/s12883-014-0178-z
Kalimeris K, Kouni S, Kostopanagiotou G, Nomikos T, Fragopoulou E, Kakisis J, Vasdekis S, Matsota P, Pandazi A. Cognitive function and oxidative stress after carotid endarterectomy: comparison of propofol to sevoflurane anesthesia. J Cardiothor Vasc An. 2013;27(6): 1246-1252. doi: 10.1053/j.jvca.2012.12.009
Blaisdell FW. The pathophysiology of skeletal muscle ischemia and the reperfusion syndrome: a review. Cardiovasc Surg. 2002;10(6): 620-630. doi:10.1016/s0967-2109(02)00070-4.
Katzen BT, MacLean AA. Complications of endovascular repair of abdominal aortic aneurysms: a review. Cardiovasc Intervent Radiol. 2006;29(6): 935-946. doi: 10.1007/s00270-005-0191-0
Onk D, Coskun R, Onk OA, Cimen FK, Kurt N, Suleyman B, Mammadov R, Altuner D, Gul V, Malkoc I, Bilgin AO, Suleyman H. The effect of esomeprazole on postoperative pain and lung and heart complications in rats. Lat Am J Pharm. 2018;37(6):1182-1191.
Yu Y, Cui WH, Cheng C, Lu Y, Zhang Q, Han RQ. Association between neutrophilto-lymphocyte ratio and major postoperative complications after carotid endarterectomy: A retrospective cohort study. World J Clin Cases. 2021;9(35):10816-10827.doi: 10.12998/wjcc.v9.i35.10816
Godet G, Bernard JM, Bertrand M, Fusciardi J, Kieffer E, Coriat P, Petitjean C, Viars P. Hemodynamic effect of the clamping of the carotid in the surgically treated coronary patient. Ann Fr Anesth Reanim. 1986;5(5): 473-478. doi: 10.1016/s0750-7658(86)80031-4.
Cordwell SJ, Edwards AVG, Liddy KA, Moshkanbaryans L, Solis N, Parker BL, Yong ASC, Wong C, Kritharides L, Hambly BD, White MY. Release of tissue-specific proteins into coronary perfusate as a model for biomarker discovery in myocardial ischemia/reperfusion injury. J Proteome Res. 2012;11(4): 2114-2126. doi: 10.1021/pr2006928.
Mahmoud KM, Ammar AS. Effect of Nacetylcysteine on cardiac injury and oxidative stress after abdominal aortic aneurysm repair: A randomized controlled trial. Acta Anaesth Scand. 2011;55(8): 1015-1021. doi: 10.1111/j.1399-6576.2011.02492.x.
Sica DA. Loop diuretic therapy, thiamine balance, and heart failure. Congest Heart Fail. 2007;13(4): 244-247. doi: 10.1111/j.1527-5299.2007.06260.x.
Rindi G, Patrini C, Laforenza U, Mandel H, Berant M, Viana MB, Poggi V, Zarra AN. Further studies on erythrocyte thiamin transport and phosphorylation in seven patients with thiamin-responsive megaloblastic anaemia. J Inherited Metab Dis;17(6):667-677. doi: 10.1007/BF0071 2009.
Ozer M, Ince S, Gundogdu B, Aktas M, Uzel K, Gursul C, Suleyman H, Suleyman Z. Effect of thiamine pyrophosphate on cyclophosphamide-induced oxidative ovarian damage and reproductive dysfunction in female rats. Adv Clin Exp Med. 2022;31(2): 129-137. doi: 10.17219/acem/142535.
Polat B, Suleyman H, Sener E, Akcay F. Examination of the effects of thiamine and thiamine pyrophosphate on doxorubicin-induced experimental cardiotoxicity. J Cardiovasc Pharmacol Ther. 2015;20(2):221- 229. doi: 10.1177/1074248414552901.
Kurt A, Isaoglu U, Yilmaz M, Calik M, Polat B, Hakan H, Ingec M, Suleyman Biochemical and histological investigation of famotidine effect on postischemic reperfusion injury in the rat ovary. J Pediatr Surg. 2011;46(9): 1817-1823. doi: 10.1016/j.jpedsurg.2011.04.092.
Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of proteindye binding. Anal Biochem. 1976;72:248-254.
Ozoner B, Yuceli S, Aydin S, Yazici GN, Sunar M, Arslan YK, Coban TA, Suleyman Effects of pycnogenol on ischemia/reperfusion-induced inflammatory and oxidative brain injury in rats. Neurosci Lett. 2019;704:169-175. doi: 10.1016/j.neulet.2019.04.010.
Frick T, Springe D, Grandgirard D, Leib SL, Haenggi M. An improved simple rat model for global cerebral ischaemia by induced cardiac arrest. Neurol Res. 2016;38(4): 373-380. doi: 10. 1179/1743132815Y.0000000090.
Wang R, Liu YY, Liu XY, Jia SW, Zhao J, Cui D, Wang L. Resveratrol protects neurons and the myocardium by reducing oxidative stress and ameliorating mitochondria damage in a cerebral ischemia rat model. Cell Physiol Biochem. 2014;34(3): 854-864. doi: 10.1159/000366304.
Ojo OB, Grace Boluwatife Olagunju, Olajide AO, Jegede ME, Fakorede AS, Crown OO, Olaleye MT, Akinmoladun AC. Spondias mombin leaf extract ameliorates cerebral ischemia/reperfusion-induced cardiohepatorenal oxidative stress in rats. Phytomedicine Plus. 2022;2(1): 100196. doi: 10.1016/j.phyplu.2021.100196.
Chen CH, Hsieh CL. Effect of acupuncture on oxidative stress induced by cerebral ischemia-reperfusion injury. Antioxidants-Basel. 2020;9(3)248.doi: 10.3390/antiox9 030248.
Su D, Li P, Wang X, Zhang W, Zhang YD, Wu CC, Zhang W, Li Y, Tai WJ, Tang B. Observing malondialdehyde-mediated signaling pathway in cerebral ischemia reperfusion injury with a specific nanolight. Anal Chem. 2020;92(3): 2748-2755. doi:10.1021/acs.analchem.9b05008
Yasar H, Demirdogen F, Suleyman B, Mammadov R, Altuner D, Coban TA, Bulut S, Gursul C, Suleyman H. Effect of thiamine pyrophosphate upon oxidative brain injury induced by ischemia-reperfusion in rats. Int J Pharmacol. 2023;19(2): 277-285. doi: 10.3923/ijp.2023.277.285
Jurcau A, Ardelean AI. Oxidative stress in ischemia/reperfusion injuries following acute ischemic stroke. Biomedicines. 2022;10(3):574. doi: 10.3390/biomedicines10030574
Higashi Y, Aratake T, Shimizu T, Shimizu S, Saito M. Protective role of glutathione in the hippocampus after brain ischemia. Int J Mol Sci. 2021;22(15): 7765. doi: 10.3390/ijms22157765.
Goshovska YV, Fedichkina RA, Balatskyi VV, Piven OO, Dobrzyn P, Sagach VF. Induction of glutathione synthesis provides cardioprotection regulating no, ampk and ppara signaling in ischemic rat hearts. Life (Basel). 2021;11(7): 631 doi: 10.3390/life11070631.
He L, He T, Farrar S, Ji LB, Liu TY, Ma X. Antioxidants maintain cellular redox homeostasis by elimination of reactive oxygen species. Cell Physiol Biochem 2017;44(2): 532-553. doi: 10.1159/000485089
Wang T, Chen HB, Xia SY, Chen XF, Sun H, Xu ZX. Ameliorative effect of parishin c against cerebral ischemia-induced brain tissue injury by reducing oxidative stress and inflammatory responses in rat model. Neuropsych Dis Treat. 2021;17:1811-1823. doi: 10.2147/NDT.S309065.
Sharipov RR, Kotsiuruba AV, Kop”iak BS, Sahach VF. Induction of oxidative stress in heart mitochondria in brain focal ischemia-reperfusion and protective effect of ecdysterone. Fiziol Zh 1994. 2014;60(3):11-17.
Turan MI, Cayir A, Cetin N, Suleyman H, Siltelioglu Turan I, Tan H. An investigation of the effect of thiamine pyrophosphate on cisplatin-induced oxidative stress and DNA damage in rat brain tissue compared with thiamine: thiamine and thiamine pyrophosphate effects on cisplatin neurotoxicity. Hum Exp Toxicol. 2014;33(1): 14-21. doi: 10.1177/0960327113485251.
Jurcau A, Simion A. Neuroinflammation in cerebral ischemia and ischemia/reperfusion injuries: from pathophysiology to therapeutic strategies. Int J Mol Sci. 2021;23(1): 14. doi 10.3390/ijms230100 14.
Zhu H, Hu S, Li Y, Sun Y, Xiong X, Hu X, Chen J, Qiu S. Interleukins and ischemic stroke. Front Immunol. 2022;13:828447. doi: 10.3389/fimmu.2022.828447.
Liu SZ, He Y, Shi J, Liu LL, Ma H, He L, Guo YQ. Allicin attenuates myocardial ischemia reperfusion injury in rats by inhibition of inflammation and oxidative stress. Transpl P. 2019;51(6): 2060-2065. doi:10.1016/j.transproceed.2019.04.039.
Dossabhoy S, Arya S. Epidemiology of atherosclerotic carotid artery disease. Semin Vasc Surg. 2021;34(1):3-9. doi: 10.1053/j.semvascsurg.2021.02.013
3.
Sirimarco G, Amarenco P, Labreuche J, Touboul PJ, Alberts M, Goto S, Rother J, Mas JL, Bhatt DL, Steg PG; REACH Registry Investigators. Carotid atherosclerosis and risk of subsequent coronary event in outpatients with atherothrombosis. Stroke. 2013;44(2): 373-379. doi: 10.1161/STROKEAHA.112.673129
Hsu JC, Tsai HL. Endovascular recanalization of common carotid artery Total occlusion: two case reports and literature review. CVIR Endovasc. 2020;3(1): 6. doi: 10.1186/s42155-020-0097-6.
Kragsterman B, Bergqvist D, Siegbahn A, Parsson H. Carotid endarterectomy induces the release of inflammatory markers and the activation of coagulation as measured in the jugular bulb. J Stroke Cerebrovasc. 2017;26(10): 2320-2328. doi: 10.1016/j.jstrokecerebrovas- dis.2017.05.020.
Cho HJ, Kim YJ, Lee JH, Choi JW, Moon WJ, Roh HG, Chun YI, Kim HY. Post-carotid stenting reperfusion injury with bloodbrain barrier disruption on gadoliniumen hanced FLAIR MRI. BMC Neurol. 2014;14: 178. doi: 10.1186/s12883-014-0178-z
Kalimeris K, Kouni S, Kostopanagiotou G, Nomikos T, Fragopoulou E, Kakisis J, Vasdekis S, Matsota P, Pandazi A. Cognitive function and oxidative stress after carotid endarterectomy: comparison of propofol to sevoflurane anesthesia. J Cardiothor Vasc An. 2013;27(6): 1246-1252. doi: 10.1053/j.jvca.2012.12.009
Blaisdell FW. The pathophysiology of skeletal muscle ischemia and the reperfusion syndrome: a review. Cardiovasc Surg. 2002;10(6): 620-630. doi:10.1016/s0967-2109(02)00070-4.
Katzen BT, MacLean AA. Complications of endovascular repair of abdominal aortic aneurysms: a review. Cardiovasc Intervent Radiol. 2006;29(6): 935-946. doi: 10.1007/s00270-005-0191-0
Onk D, Coskun R, Onk OA, Cimen FK, Kurt N, Suleyman B, Mammadov R, Altuner D, Gul V, Malkoc I, Bilgin AO, Suleyman H. The effect of esomeprazole on postoperative pain and lung and heart complications in rats. Lat Am J Pharm. 2018;37(6):1182-1191.
Yu Y, Cui WH, Cheng C, Lu Y, Zhang Q, Han RQ. Association between neutrophilto-lymphocyte ratio and major postoperative complications after carotid endarterectomy: A retrospective cohort study. World J Clin Cases. 2021;9(35):10816-10827.doi: 10.12998/wjcc.v9.i35.10816
Godet G, Bernard JM, Bertrand M, Fusciardi J, Kieffer E, Coriat P, Petitjean C, Viars P. Hemodynamic effect of the clamping of the carotid in the surgically treated coronary patient. Ann Fr Anesth Reanim. 1986;5(5): 473-478. doi: 10.1016/s0750-7658(86)80031-4.
Cordwell SJ, Edwards AVG, Liddy KA, Moshkanbaryans L, Solis N, Parker BL, Yong ASC, Wong C, Kritharides L, Hambly BD, White MY. Release of tissue-specific proteins into coronary perfusate as a model for biomarker discovery in myocardial ischemia/reperfusion injury. J Proteome Res. 2012;11(4): 2114-2126. doi: 10.1021/pr2006928.
Mahmoud KM, Ammar AS. Effect of Nacetylcysteine on cardiac injury and oxidative stress after abdominal aortic aneurysm repair: A randomized controlled trial. Acta Anaesth Scand. 2011;55(8): 1015-1021. doi: 10.1111/j.1399-6576.2011.02492.x.
Sica DA. Loop diuretic therapy, thiamine balance, and heart failure. Congest Heart Fail. 2007;13(4): 244-247. doi: 10.1111/j.1527-5299.2007.06260.x.
Rindi G, Patrini C, Laforenza U, Mandel H, Berant M, Viana MB, Poggi V, Zarra AN. Further studies on erythrocyte thiamin transport and phosphorylation in seven patients with thiamin-responsive megaloblastic anaemia. J Inherited Metab Dis;17(6):667-677. doi: 10.1007/BF0071 2009.
Ozer M, Ince S, Gundogdu B, Aktas M, Uzel K, Gursul C, Suleyman H, Suleyman Z. Effect of thiamine pyrophosphate on cyclophosphamide-induced oxidative ovarian damage and reproductive dysfunction in female rats. Adv Clin Exp Med. 2022;31(2): 129-137. doi: 10.17219/acem/142535.
Polat B, Suleyman H, Sener E, Akcay F. Examination of the effects of thiamine and thiamine pyrophosphate on doxorubicin-induced experimental cardiotoxicity. J Cardiovasc Pharmacol Ther. 2015;20(2):221- 229. doi: 10.1177/1074248414552901.
Kurt A, Isaoglu U, Yilmaz M, Calik M, Polat B, Hakan H, Ingec M, Suleyman Biochemical and histological investigation of famotidine effect on postischemic reperfusion injury in the rat ovary. J Pediatr Surg. 2011;46(9): 1817-1823. doi: 10.1016/j.jpedsurg.2011.04.092.
Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of proteindye binding. Anal Biochem. 1976;72:248-254.
Ozoner B, Yuceli S, Aydin S, Yazici GN, Sunar M, Arslan YK, Coban TA, Suleyman Effects of pycnogenol on ischemia/reperfusion-induced inflammatory and oxidative brain injury in rats. Neurosci Lett. 2019;704:169-175. doi: 10.1016/j.neulet.2019.04.010.
Frick T, Springe D, Grandgirard D, Leib SL, Haenggi M. An improved simple rat model for global cerebral ischaemia by induced cardiac arrest. Neurol Res. 2016;38(4): 373-380. doi: 10. 1179/1743132815Y.0000000090.
Wang R, Liu YY, Liu XY, Jia SW, Zhao J, Cui D, Wang L. Resveratrol protects neurons and the myocardium by reducing oxidative stress and ameliorating mitochondria damage in a cerebral ischemia rat model. Cell Physiol Biochem. 2014;34(3): 854-864. doi: 10.1159/000366304.
Ojo OB, Grace Boluwatife Olagunju, Olajide AO, Jegede ME, Fakorede AS, Crown OO, Olaleye MT, Akinmoladun AC. Spondias mombin leaf extract ameliorates cerebral ischemia/reperfusion-induced cardiohepatorenal oxidative stress in rats. Phytomedicine Plus. 2022;2(1): 100196. doi: 10.1016/j.phyplu.2021.100196.
Chen CH, Hsieh CL. Effect of acupuncture on oxidative stress induced by cerebral ischemia-reperfusion injury. Antioxidants-Basel. 2020;9(3)248.doi: 10.3390/antiox9 030248.
Su D, Li P, Wang X, Zhang W, Zhang YD, Wu CC, Zhang W, Li Y, Tai WJ, Tang B. Observing malondialdehyde-mediated signaling pathway in cerebral ischemia reperfusion injury with a specific nanolight. Anal Chem. 2020;92(3): 2748-2755. doi:10.1021/acs.analchem.9b05008
Yasar H, Demirdogen F, Suleyman B, Mammadov R, Altuner D, Coban TA, Bulut S, Gursul C, Suleyman H. Effect of thiamine pyrophosphate upon oxidative brain injury induced by ischemia-reperfusion in rats. Int J Pharmacol. 2023;19(2): 277-285. doi: 10.3923/ijp.2023.277.285
Jurcau A, Ardelean AI. Oxidative stress in ischemia/reperfusion injuries following acute ischemic stroke. Biomedicines. 2022;10(3):574. doi: 10.3390/biomedicines10030574
Higashi Y, Aratake T, Shimizu T, Shimizu S, Saito M. Protective role of glutathione in the hippocampus after brain ischemia. Int J Mol Sci. 2021;22(15): 7765. doi: 10.3390/ijms22157765.
Goshovska YV, Fedichkina RA, Balatskyi VV, Piven OO, Dobrzyn P, Sagach VF. Induction of glutathione synthesis provides cardioprotection regulating no, ampk and ppara signaling in ischemic rat hearts. Life (Basel). 2021;11(7): 631 doi: 10.3390/life11070631.
He L, He T, Farrar S, Ji LB, Liu TY, Ma X. Antioxidants maintain cellular redox homeostasis by elimination of reactive oxygen species. Cell Physiol Biochem 2017;44(2): 532-553. doi: 10.1159/000485089
Wang T, Chen HB, Xia SY, Chen XF, Sun H, Xu ZX. Ameliorative effect of parishin c against cerebral ischemia-induced brain tissue injury by reducing oxidative stress and inflammatory responses in rat model. Neuropsych Dis Treat. 2021;17:1811-1823. doi: 10.2147/NDT.S309065.
Sharipov RR, Kotsiuruba AV, Kop”iak BS, Sahach VF. Induction of oxidative stress in heart mitochondria in brain focal ischemia-reperfusion and protective effect of ecdysterone. Fiziol Zh 1994. 2014;60(3):11-17.
Turan MI, Cayir A, Cetin N, Suleyman H, Siltelioglu Turan I, Tan H. An investigation of the effect of thiamine pyrophosphate on cisplatin-induced oxidative stress and DNA damage in rat brain tissue compared with thiamine: thiamine and thiamine pyrophosphate effects on cisplatin neurotoxicity. Hum Exp Toxicol. 2014;33(1): 14-21. doi: 10.1177/0960327113485251.
Jurcau A, Simion A. Neuroinflammation in cerebral ischemia and ischemia/reperfusion injuries: from pathophysiology to therapeutic strategies. Int J Mol Sci. 2021;23(1): 14. doi 10.3390/ijms230100 14.
Zhu H, Hu S, Li Y, Sun Y, Xiong X, Hu X, Chen J, Qiu S. Interleukins and ischemic stroke. Front Immunol. 2022;13:828447. doi: 10.3389/fimmu.2022.828447.
Liu SZ, He Y, Shi J, Liu LL, Ma H, He L, Guo YQ. Allicin attenuates myocardial ischemia reperfusion injury in rats by inhibition of inflammation and oxidative stress. Transpl P. 2019;51(6): 2060-2065. doi:10.1016/j.transproceed.2019.04.039.
Publicado
2024-05-21
Cómo citar
Emir, I., Suleyman, Z., & Suleyman, H. (2024). Effect of thiamine pyrophosphate on oxidative damage in the brain and heart of rats with experimentally induced occlusion of the common carotid artery.: Efecto del pirofosfato de tiamina sobre el daño oxidativo en el cerebro y el corazón de ratas con oclusión inducida experimentalmente de la arteria carótida común. Investigación Clínica, 65(2), 220-229. https://doi.org/10.54817/IC.v65n2a08
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