Evidencia sobre el efecto anticariogénicode pastas dentales que contienen arginina: una revisión sistemática.
Evidence on the anticariogenic effect of arginine-containing toothpastes: a systematic review.
Palabras clave:
arginina, fluoruro, dentífrico, prevención, caries dentales
Resumen
Las bacterias arginolíticas metabolizan la arginina que se en-cuentra en la saliva produciendo amoníaco, el cual potencialmente es un factor endógeno de inhibición de la microbiota cariogénica. Las pastas dentales con arginina podrían brindar mayor disponibilidad de dicho compuesto y, por tanto, ayudar a la prevención de caries.El propósito de esta revisión fueevaluar la evi-dencia publicada acerca del efecto anticariogénico de pastas dentales que con-tienen arginina. Se realizó una revisión sistemática de literatura, en las bases de datos PubMed, Scholar Google y Web of Science, publicada en el período 2010 a 2020. Los criterios de elegibilidad fueron artículos originales con diseño de ensayos clínicos aleatorizados y observacionales, en texto completo en inglés o español, con participantes de todas las edades, en los cuales se hubiera evalua-do el efecto anticariogénico de la arginina. De los 424 registros identificados, se revisaron 42 artículos en texto completo. De éstos, siete estudios se seleccio-naron por cumplir los criterios de elegibilidad. En tres estudios se observó una disminución en el incremento de procesos cariosos, dos estudios determinaron que la actividad del sistema arginina deiminasa es mayor, la remineralización de lesiones incipientes en esmalte lo reportan dos estudios, así como la reduc-ción en la producción de ácido láctico. No se reportaron efectos secundarios relacionados con la arginina. Con base en el análisis de los estudios incluidos, se concluye que los dentífricos que contienen una combinación de fluoruro y arginina, poseen una mayor cantidad de beneficios y actividad anticariogénica cuando se comparan con dentífricos convencionales.
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Citas
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Berto A, Lauener A, Saads T, Lussi A, Eick S. In vitro effects of arginine containing toothpastes on cariogenic biofilms. Oral Health Prev Dent 2019; 17: 375-383.
Xue Y, Lu Q, Tian Y, Zhou X, Cheng L, Ren B. Effect of toothpaste containing arginine on dental plaque—A randomized controlled in situ study. J Dent 2017; 67: 88-93.
Marsh PD. Dental plaque: biological significance of a biofilm and community life-style. J Clin Periodontol 2005; 32: 7-15.
Featherstone JDB. Dental caries: a dynamic disease process. Aust Dent J 2008; 53: 286-291.
Ástvaldsdóttir A, Naimi Akbar A, Davidson T, Brolund A, Lintamo L, Attergren A, Tranæus S, Östlund P. Arginine and caries prevention: A systematic review. Caries Res 2016; 50: 383-393.
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Argueta L, Martínez O, Santos J, García R, Acosta L, De la fuente J, Arenas M. Nanomateriales made of non-toxic metallic sulfides: a systematic review of their potential biomedical applications. Mater Sci Eng C Mater Biol Appl 2017; 76: 1305-1315.
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Torres R, Torres N, Moreno A, Garcia R, Argueta L. Anti-inflammatory and antibacterial activity of the Chitosan/Chlorhexidine gel commercial preparation for pos-texodontia treatment: an in vitro study. Eur J Dent 2020; 14: 397-403.
Chakraborty B, Burne A. Effects of arginine on Streptococcus mutans growth, virulence gene expression, and stress tolerance. Appl Environ Microbiology 2017; 83: 1-13.
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Reyes É, Martín J, Yevenes I, Neira M, Palma P, Gordan V, Moncada G. Actividad y efectos de ureasa y arginina deiminasa en saliva y biopelícula oral humana. Rev Fac Odontol Univ Antioq 2012; 23: 343-352.
Kraivaphan P, Amornchat C, Triratana T, Mateo R, Ellwood P, Cummins D, DeVizio W, Zhang P. Two-year caries clinical study of the efficacy of novel dentifrices containing 1,5% arginine, an insoluble calcium com¬pound and 1450 ppm fluoride. Caries Res 2013; 47: 582-590.
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Srisilapanan P, Korwanich N, Yin W, Chuensuwonkul C, Mateo R, Zhang P, Cummins D, Ellwood P. Comparison of the efficacy of a dentifrice containing 1,5% arginine and 1450 ppm fluoride to a dentifrice containing 1450 ppm fluoride alone in the management of early coronal caries as assessed using Quantitative Light-induced Fluorescence. J Dent 2013: s29-s34.
Nascimento N, Browngardt C, Xiaohui X, Klepac-Ceraj V, Paster J, Burne A. The effect of arginine on oral biofilm communities. Mol Oral Microbiol 2014; 29: 45-54.
Li X, Zhong Y, Jiang X, Hu D, Mateo R, Morrison M, Zhang Y. Randomized clinical trial of the efficacy of dentifrices containing 1,5% arginine, an insoluble calcium compound and 1450 ppm fluoride over two years. J Clin Dent 2015; 26: 7-12.
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Campus G, Cocco F, Ottolenghi L, Cagetti Comparison of ICDAS, CAST, Nyvad’s criteria, and WHO-DMFT for caries detection in a sample of Italian schoolchildren. Int J Environ Res Public Health 2019; 16: 4120-4134.
Taqi M, Razak A, AB Murat N. Comparing dental caries status using Modified International Caries Detection and Assessment System (ICDAS) and World Health Organization (WHO) indices among school children of Bhakkar, Pakistan. J Pak Med Assoc 2019; 69: 950-954.
Pretty A, Ellwood P. The caries continuum: opportunities to detect, treat and monitor the remineralization of early caries lesions. J Dent 2013: s12-s21.
Li J, Huang Z, Mei L, Li G, Li H. Anti caries effect of arginine-containing formulaions in vivo: A systematic review and meta-analysis. Caries Res 2015; 49: 606-617.
Lundh A, Lexchin J, Mintzes B, Schroll B, Bero L. Industry sponsorship and research outcome. Cochrane Database Sys Rev 2017; 2: MR000033.
Berto A, Lauener A, Saads T, Lussi A, Eick S. In vitro effects of arginine containing toothpastes on cariogenic biofilms. Oral Health Prev Dent 2019; 17: 375-383.
Xue Y, Lu Q, Tian Y, Zhou X, Cheng L, Ren B. Effect of toothpaste containing arginine on dental plaque—A randomized controlled in situ study. J Dent 2017; 67: 88-93.
Marsh PD. Dental plaque: biological significance of a biofilm and community life-style. J Clin Periodontol 2005; 32: 7-15.
Featherstone JDB. Dental caries: a dynamic disease process. Aust Dent J 2008; 53: 286-291.
Ástvaldsdóttir A, Naimi Akbar A, Davidson T, Brolund A, Lintamo L, Attergren A, Tranæus S, Östlund P. Arginine and caries prevention: A systematic review. Caries Res 2016; 50: 383-393.
Argueta L, Torres N, Garcia R, Vilchis A, Martínez O, Acosta L, Arenas M. Hydrotherpound and 1450 ppm fluoride. Caries Res 2013; 47: 582-590.
Argueta L, Martínez O, Santos J, García R, Acosta L, De la fuente J, Arenas M. Nanomateriales made of non-toxic metallic sulfides: a systematic review of their potential biomedical applications. Mater Sci Eng C Mater Biol Appl 2017; 76: 1305-1315.
Argueta L, Arenas M, Díaz A, García S, García R. Propiedades antimicrobianas y ci- totóxicas de un adhesivo de uso ortodóncico adicionado con nanoparticulas de plata. Mundo Nano 2019; 12: 1e-13e.
Argueta L, Morales R, Scougall R, Olea O. Synthesis, characterization and antibacte-rial activity of copper, nickel and bimetallic Cu-Ni nanoparticles for potential use in dental materials. Prog. Nat. Sci. 2014; 24: 321-328.
Torres R, Torres N, Moreno A, Garcia R, Argueta L. Anti-inflammatory and antibacterial activity of the Chitosan/Chlorhexidine gel commercial preparation for pos-texodontia treatment: an in vitro study. Eur J Dent 2020; 14: 397-403.
Chakraborty B, Burne A. Effects of arginine on Streptococcus mutans growth, virulence gene expression, and stress tolerance. Appl Environ Microbiology 2017; 83: 1-13.
Gurenlian JR. The role of dental plaque biofilm in oral health. J Dent Hyg 2007; 81: 1-11.
Souza R, Cury JA, Tenuta A, Zhang P, Mateo R, Cummins D, Ellwod P. Comparing the efficacy of a dentifrice containing 1,5 arginine and 1450 ppm fluoride to a dentifrice containing 1450 ppm fluoride alone in the management of primary root caries. J Dent 2010; 38: 34-40.
Reyes É, Martín J, Yevenes I, Neira M, Palma P, Gordan V, Moncada G. Actividad y efectos de ureasa y arginina deiminasa en saliva y biopelícula oral humana. Rev Fac Odontol Univ Antioq 2012; 23: 343-352.
Kraivaphan P, Amornchat C, Triratana T, Mateo R, Ellwood P, Cummins D, DeVizio W, Zhang P. Two-year caries clinical study of the efficacy of novel dentifrices containing 1,5% arginine, an insoluble calcium com¬pound and 1450 ppm fluoride. Caries Res 2013; 47: 582-590.
Cheng X, Xu P, Zhou X, Deng M, Cheng L, Li M, Li Y, Xu X. Arginine promotes fluori¬de uptake into artificial carious lesions in vitro. Aust Dent J 2015; 60: 104-111.
Fernández M, Martinez A, Arriarán E, Gu- tiérrez D, Toriz H, Lifshitz A. Uso de los MeSH. Inv Ed Med 2016; 5: 220-229.
Urrútia G, Bonfill X. Declaración PRISMA: una propuesta para mejorar la publicación de revisiones sistemáticas y metanálisis. Med Clin (Barc) 2010; 135: 507-511.
Moher D, Liberati A, Tetzlaff J, Altman The PRISMA group. Preferred reporting tems for systematic review and meta-analyses: The PRISMA statement. PLoS Med. 2009; 6: e1000097. doi: 10.1371/journal. pmed1000097.
Higgins JPT, Savovi´c J, Page MJ, Elbers RG, Sterne JAC. Chapter 8: Assessing risk of bias in a randomized trial. In: Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, Welch VA (editors). Cochrane Handbook for Systematic Reviews of Interventions version 6.2 (updated February 2021). Cochrane, 2021. Available from http://www. training.cochrane.org/handbook
Sterne JAC, Savovi´c J, Page MJ, Elbers RG, Blencowe NS, Boutron I, Cates CJ, Cheng HY, Corbett MS, Eldridge SM, Emberson JR, Hernán MA, Hopewell S, Hróbjsrtsson A, Junqueira DR, Jüni P, Kirkham JJ, Lasserson T, Li T, McAleenan A, Reeves BC, Shepperd S, Shrier I, Stewart LA, Tilling K, White IR, Whiting PF, Higgins JPT. RoB 2 a revised tool for assessing risk of bias in randomized trials. BMJ. 2019; 366: I4898.
Yin W, Hu Y, Li X, Fan X, Zhang P, Pretty A, Mateo R, Cummins D, Ellwood P. The anti-caries efficacy of a dentifrice containing 1,5% arginine and 1450 ppm fluoride as so- dium monofluorophosphate assessed using Quantitative Light-induced Fluorescence (QLF). J Dent 2013: s22-s28.
Srisilapanan P, Korwanich N, Yin W, Chuensuwonkul C, Mateo R, Zhang P, Cummins D, Ellwood P. Comparison of the efficacy of a dentifrice containing 1,5% arginine and 1450 ppm fluoride to a dentifrice containing 1450 ppm fluoride alone in the management of early coronal caries as assessed using Quantitative Light-induced Fluorescence. J Dent 2013: s29-s34.
Nascimento N, Browngardt C, Xiaohui X, Klepac-Ceraj V, Paster J, Burne A. The effect of arginine on oral biofilm communities. Mol Oral Microbiol 2014; 29: 45-54.
Li X, Zhong Y, Jiang X, Hu D, Mateo R, Morrison M, Zhang Y. Randomized clinical trial of the efficacy of dentifrices containing 1,5% arginine, an insoluble calcium compound and 1450 ppm fluoride over two years. J Clin Dent 2015; 26: 7-12.
Nascimento M, Alvarez J, Huang X, Browngardt C, Jenkins R, Sinhoreti C, Ribeiro D, Dilbone A, Richards P, Garrett J, Burne A. Metabolic profile of supragingival plaque exposed to arginine and fluoride. J Dent Res 2019; 98: 1245-1252.
Campus G, Cocco F, Ottolenghi L, Cagetti Comparison of ICDAS, CAST, Nyvad’s criteria, and WHO-DMFT for caries detection in a sample of Italian schoolchildren. Int J Environ Res Public Health 2019; 16: 4120-4134.
Taqi M, Razak A, AB Murat N. Comparing dental caries status using Modified International Caries Detection and Assessment System (ICDAS) and World Health Organization (WHO) indices among school children of Bhakkar, Pakistan. J Pak Med Assoc 2019; 69: 950-954.
Pretty A, Ellwood P. The caries continuum: opportunities to detect, treat and monitor the remineralization of early caries lesions. J Dent 2013: s12-s21.
Li J, Huang Z, Mei L, Li G, Li H. Anti caries effect of arginine-containing formulaions in vivo: A systematic review and meta-analysis. Caries Res 2015; 49: 606-617.
Lundh A, Lexchin J, Mintzes B, Schroll B, Bero L. Industry sponsorship and research outcome. Cochrane Database Sys Rev 2017; 2: MR000033.
Publicado
2021-06-10
Cómo citar
Rubín De Celis-Quintana, G. N., Moreno-Rodríguez, A., Torres-Rosas, R., & Argueta-Figueroa, L. (2021). Evidencia sobre el efecto anticariogénicode pastas dentales que contienen arginina: una revisión sistemática.: Evidence on the anticariogenic effect of arginine-containing toothpastes: a systematic review. Investigación Clínica, 62(2), 169-188. https://doi.org/10.22209/IC.v62n2a07
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