Modulación del pensamiento catastrófico, dolor e inflamación en fibromialgia. Del comportamiento a la biología molecular.

Modulation of catastrophic thinking, pain and inflammation in fibromyalgia: from behavior to molecular biology.

  • Ana Karen Sandoval Valerio Instituto Politécnico Nacional
  • Víctor Ricardo Aguilera-Sosa Instituto Politécnico Nacional
  • Ángel Miliar García Instituto Politécnico Nacional
  • Modesto Gómez López Instituto Politécnico Nacional
  • Conrado García García Instituto Politécnico Nacional
  • Gerardo Leija Alva Instituto Politécnico Nacional
  • Jennifer V. Sánchez-Camacho Universidad Estatal del Valle de Ecatepec
  • Nadia Mabel Pérez-Vielma Instituto Politécnico Nacional
Palabras clave: fibromialgia, intervención cognitivo conductual, IL -6, cortisol, intervención psicofisiológica, pensamiento catastrófico

Resumen

La fibromialgia (FM) se caracteriza por la presencia de dolor crónico (DC), estrés y alteraciones cognitivas. La evidencia sugiere que el pensamiento catastrófico (PC) es una constante en esta población, mediado por cortisol, IL -6 y el gen que codifica para el receptor de serotonina 5HT1A (5HT1A). El objetivo de la presente investigación fue identificar si la modifica-ción del PC impacta en estas variables biológicas, para lo cual se compararon los efectos de una intervención cognitivo-conductual (ICC) con los de una inter-vención psicofisiológica (IPF), en un grupo de mujeres con FM. Fue un estudio no probabilístico, comparativo, experimental y clínico, que tuvo una duración de 11 semanas. Participaron 48 mujeres pacientes del servicio de reumatología del Hospital General de México. Se aplicaron el Cuestionario de Evaluación de la Salud (CES), Escala Catastrófica para Fibromialgia (ECF) y la Escala de Estrés Percibido (EEP). Se cuantificaron la expresión relativa de los genes IL -6 y del receptor de serotonina (5HT1A), mediante PCR en tiempo real, y se de-terminaron los niveles séricos de IL -6 y cortisol. La ICC produjo cambios signi-ficativos en la percepción de estrés (p=0,05), en PC en la escalas de rumiación (p=0,05), en la magnificación (p=0,01), la desesperanza (p=0,01), el cortisol (p=0,01) y la IL -6 (p=0,01); los puntajes de dolor mejoraron en ambos grupos (p=0.01). La IPF por su parte, mostró un incremento en la expresión relativa del gen que codifica para el receptor de serotonina 5HT1A (p=,05). En el grupo de ICC se encontró que la IL -6 es una variable predictora del pensamiento de rumiación. Los resultados permiten concluir que la ICC tuvo mayor impacto en el PC, el estrés, la IL -6 y el cortisol, en comparación con la IPF.

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Publicado
2021-06-10
Cómo citar
Sandoval Valerio, A. K., Aguilera-Sosa, V. R., Miliar García, Ángel, Gómez López, M., García García, C., Leija Alva, G., Sánchez-Camacho, J. V., & Pérez-Vielma, N. M. (2021). Modulación del pensamiento catastrófico, dolor e inflamación en fibromialgia. Del comportamiento a la biología molecular.: Modulation of catastrophic thinking, pain and inflammation in fibromyalgia: from behavior to molecular biology. Investigación Clínica, 62(2), 140-158. https://doi.org/10.22209/IC.v62n2a05
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