Manganese Toxicity: Free amino acids in the striatum and olfactory bulb of the mouse

• Ernesto Bonilla Universidad del Zulia-Venezuela
• Arelis Arrieta Fundación para el Desarrollo de la Ciencia y la Tecnología en el Estado Zulia FUNDACITE- Venezuela
• Fidel Castro Fundación para el Desarrollo de la Ciencia y la Tecnología en el Estado Zulia FUNDACITE-Venezuela
• José Omar Dávila Universidad del Zulia-Venezuela
• Iris Quiroz Universidad del Zulia-Venezuela

Palabras clave: Manganese poisoning, amino acids, olfactory bulb, GABA, striatum

Resumen

 

We studied the levels of twenty two free amino acids in the striatum and olfactory bulb of mice treated during nine weeks with daily intraperitoneal injections of manganese chloride at a concentration of 5.0 mg Mn+2¡kg body weight. In the olfactory bulb the contents of alanine, a-amino-n-butyrate. arginine. asparagine, aspartate, citrulline, GABA, glutamate, glycine, isoleucine, leucine methionine, phenylalanine, serine,threonine, tyrosine, and valine were diminished. No alterations were observed in the concentrations of free amino acids in the striatum of Mn-treated mice. The changes detected in the olfactory bulb merit a thorough evaluation in order to determine its importance on the pathophysiology of manganese poisoning.