Purified Polyphenol Extracts in the Treatment of Osteopenia

• Soanna M Vílchez R School of Medicine, University of Zulia

DOI: https://doi.org/10.5281/zenodo.17979807

Keywords: Polyphenols, Osteopenia, Bone resorption, Antioxidant, Oxidative stress, Free radicals

Abstract

Various studies have established the effects of polyphenols at the cellular level and their involvement in the body's regulatory mechanisms. Their antioxidant and anti-inflammatory properties offer benefits for bone health by modulating processes such as cell apoptosis, although the intrinsic mechanisms remain under investigation. This study aims to summarize the positive effects of polyphenols on calcium homeostasis in bone. Searches were conducted in the PubMed, Scielo, and Elsevier databases using the keywords “polyphenols,” “osteopenia,” and “oxidative stress.” Studies in English and Spanish published between 2012 and 2022 that proposed polyphenol-based therapies for osteoarticular pathologies and osteopenia were included. The inclusion criteria were: peer-reviewed studies, full text access, and thematic relevance. Opinion articles and isolated clinical cases were excluded. The selection was carried out in three stages: analysis of titles and abstracts, full evaluation, and data collection in comparative tables. VOSviewer software was used to identify trends. It is concluded that, although the underlying mechanisms are under investigation, there is growing evidence of the efficacy of polyphenols in in vitro and in vivo studies, representing a therapeutic alternative in the management of osteopenia.

References

Austermann K, Baecker N, Stehle P, Heer M. (2019) Putative Effects of Nutritive Polyphenols on Bone Metabolism In Vivo-Evidence from Human Studies. Nutrients; 11(4):871. https://doi.org/10.3390/nu11040871

Chen S, Chen T, Chen Y, Huang D, Pan Y, Chen S. (2022) Causal Association Between Tea Consumption and Bone Health: A Mendelian Randomization Study. Front Nutr. 9:872451. https://doi.org/10.3389/fnut.2022.872451

Inchingolo AD, Inchingolo AM, Malcangi G, Avantario P, Azzollini D, Buongiorno S, et al. (2022) Effects of Resveratrol, Curcumin and Quercetin Supplementation on Bone Metabolism-A Systematic Review. Nutrients.14(17):3519. https://doi.org/10.3390/nu14173519

Jiang Y, Luo W, Wang B, Wang X, Gong P, Xiong Y. (2020) Resveratrol promotes osteogenesis via activating SIRT1/FoxO1 pathway in osteoporosis mice. Life Sci. 246:117422. https://doi.org/10.1016/j.lfs.2020.117422

Kondo A, Otsuka T, Kuroyanagi G, Yamamoto N, Matsushima-Nishiwaki R, Mizutani J, et al. (2014) Resveratrol inhibits BMP-4-stimulated VEGF synthesis in osteoblasts: suppression of S6 kinase. Int J Mol Med. 33(4):1013–1018. https://doi.org/10.3892/ijmm.2014.1626

Kuroyanagi G, Otsuka T, Yamamoto N, Matsushima-Nishiwaki R, Nakakami A, Mizutani J, et al. (2014) Down-regulation by resveratrol of basic fibroblast growth factor-stimulated osteoprotegerin synthesis through suppression of Akt in osteoblasts. Int J Mol Sci. 2014;15(10):17886–17900. https://doi.org/10.3390/ijms151017886

Martiniakova, M., Babikova, M., Mondockova, V., Blahova, J., Kovacova, V., & Omelka, R. (2022). El papel de los macronutrientes, micronutrientes y polifenoles flavonoides en la prevención y el tratamiento de la osteoporosis. Nutrientes, 14(3), 523. https://doi.org/10.3390/nu14030523

Nicolin, V., De Tommasi, N., Nori, S. L., Costantinides, F., Berton, F., & Di Lenarda, R. (2019). Modulatory effects of plant polyphenols on bone remodeling: A prospective view from the bench to bedside. Frontiers in Endocrinology, 10(494). https://doi.org/10.3389/fendo.2019.00494.

Niu YB, Yang YY, Xiao X, Sun Y, Zhou YM, Zhang YH, et al. (2020) Quercetin prevents bone loss in hindlimb suspension mice via stanniocalcin 1-mediated inhibition of osteoclastogenesis. Acta Pharm Sin. 41(11):1476–1486. https://doi.org/10.1038/s41401-020-00509-z

Ozaki, K., Kawata, Y., Amano, S., & Hanazawa, S. (2000). Stimulatory effect of curcumin on osteoclast apoptosis. Biochemical pharmacology, 59(12), 1577–1581. https://doi.org/10.1016/s0006-2952(00)00277-x

Quiñones M, Miguel M, Aleixandre A. (2012) Los polifenoles, compuestos de origen natural con efectos saludables sobre el sistema cardiovascular. Nutr. Hosp. 27(1):76-89. Disponible en: http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0212-16112012000100009&lng=es&tlng=es

Stride PJ, Patel N, Kingston D. (2013) The history of osteoporosis: why do Egyptian mummies have porotic bones? J R Coll Physicians Edinb. 43(3):254–261. https://doi.org/10.4997/JRCPE.2013.314

Sundarraj R, Thangaraj S, D D, Sophia D, Ragavendran P, Gopalakrishnan VK. (2011) Radical Scavenging and Antioxidant Activity of Ethanolic Extract of Mollugo nudicaulis by Invitro Assays. Indian J Pharm Educ Res.;45.

Zhao, M., Ko, S. Y., Garrett, I. R., Mundy, G. R., Gutierrez, G. E., & Edwards, J. R. (2018). The polyphenol resveratrol promotes skeletal growth in mice through a sirtuin 1-bone morphogenic protein 2 longevity axis. British journal of pharmacology, 175(21), 4183–4192. https://doi.org/10.1111/bph.14477.