Antibacterial Activity of Culantro Leaves (Coriandrum sativum L.).

DOI: https://doi.org/10.56903/kasmera.53442721
Keywords: Coriandrum, Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, anti-bacterial agents

Abstract

Coriandrum sativum (culantro) is a plant traditionally used for the treatment of microbial infections. This study evaluated the antibacterial activity of aqueous and hydroalcoholic extracts from its leaves against Pseudomonas aeruginosa, Staphylococcus aureus, and Escherichia coli (ATCC 27852, 25923, and 25922). The leaves were collected, dried, ground (≤1 mm), and extracted by ultrasound with ethanol in proportions of 50:50 and 90:10. The extracts were concentrated by rotary evaporation and drying in an air-circulating oven. Antibacterial activity was determined by the disk diffusion method on Mueller-Hinton agar at different concentrations, using bacterial inocula of 10⁸ CFU/ml. The minimum inhibitory concentration (MIC) was established by microdilution in tryptic soy broth. The in vitro results showed that the aqueous extract inhibited bacterial growth by 33%, 60%, and 42% at 4 mg/ml, while the hydroalcoholic extract (50:50) showed 67% inhibition. These findings confirm the antibacterial activity of C. sativum, suggesting its pharmacological potential and possible application in the development of natural therapeutic agents for the control of bacterial infections, contributing to the search for alternatives to antimicrobial resistance

References

Jaramillo C, San Martin D, D’Armas Regnault H. Análisis del efecto antimicrobiano de doce plantas medicinales de uso ancestral en Ecuador. Cienc UNEMI [Internet]. 2016;9(20):11-8. Disponible en: https://doi.org/10.29076/issn.2528-7737vol9iss20.2016pp11-18p DOI: 10.29076/issn.2528-7737vol9iss20.2016pp11-18p

Cruz Barrios MA, Furones Mourelle JA. Investigaciones clínicas sobre Medicina Natural y Tradicional publicadas en revistas cubanas. Rev medica electron [Internet]. 2020;42(5):2288-300. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1684-18242020000502288

Cuca Suárez LE, Coy Barrera CA, Coy Barrera ED, Lozano Moreno JM. Actividad antibacteriana de terpenoides y alcaloides aislados de tres plantas colombianas. Rev Cuba Farm [Internet]. 2011;45(2):275-82. Disponible en: https://www.medigraphic.com/cgi-bin/new/resumen.cgi?IDARTICULO=33901

Gonzáles Mendoza J, Maguiña Vargas C, Gonzáles Ponce F de M. La resistencia a los antibióticos: un problema muy serio. Acta Médica Perú [Internet]. 2019;36(2):145-51. Disponible en: https://doi.org/10.35663/amp.2019.362.816 DOI: 10.35663/amp.2019.362.816

Eddy G, Marco R, Carolina S, Lucía D, Benjamín V, Adrián Z, et al. Efecto antibacteriano del extracto metanólico de Salix babylonica sobre bacterias de importancia en salud pública. Abanico Vet [Internet]. 2020;10(1):1-11. Disponible en: https://www.medigraphic.com/cgi-bin/new/resumen.cgi?IDARTICULO=97813 DOI: 10.21929/abavet2020.1.

Sanchez-Perez JA, Castillo VB, Cotrina FV, Guevara-Granados JM. Actividad antimicrobiana de metabolitos secundarios de Aspergillus fumigatus sensu stricto sobre cepas clínicas de Staphylococcus aureus y Streptococcus pneumoniae. An la Fac Med [Internet]. 2020;81(2):180-5. Disponible en: https://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/16170 DOI: 10.15381/anales.v81i2.16170

Pazos CP, De Alejo Plain AP, Viera YR. La Medicina Natural y Tradicional como tratamiento alternativo de múltiples enfermedades. Rev Cuba Med Gen Integr [Internet]. 2019;35(2):1-18. Disponible en: https://www.medigraphic.com/pdfs/revcubmedgenint/cmi-2019/cmi192j.pdf

Mercado-Mercado G, Carrillo L de la R, Wall-Medrano A, Díaz JAL, Álvarez-Parrilla E. Compuestos polifenólicos y capacidad antioxidante de especias típicas consumidas en México. Nutr Hosp [Internet]. 2013;28(1):36-46. Disponible en: https://www.nutricionhospitalaria.org/articles/H0513/show#! DOI: 10.3305/nh.2013.28.1.6298 PMID 23808428

Pilco A, Bravo Crespo DI. Acción Antibacteriana in vitro del Taraxacun officinale frente al Acinetobacter baumannii. Rev Vive [Internet]. 2024;7(20):487-96. Disponible en: https://revistavive.org/index.php/revistavive/article/view/470 DOI: 10.33996/revistavive.v7i20.316

Cuéllar Cuéllar A, Miranda Martínez M. Manual de prácticas de laboratorio. Farmacognosia y productos naturales [Internet]. Plaza de la Revolución, Cuba: Empresa Editorial Poligráfica Félix Varela; 2014. Disponible en: https://isbn.cloud/9789590717956/manual-de-practicas-de-laboratorio-farmacognosia-y-productos-naturales/

Rojas A. L, Jaramillo J. C, Lemus B. M. Métodos analíticos para la determinación de metabolitos secundarios de plantas. [Internet]. Machala : Ecuador; 2015. Disponible en: http://repositorio.utmachala.edu.ec/handle/48000/6653

Montero-Recalde M, Vayas L, Avilés-Esquivel D, Pazmiño P, Erazo-Gutierrez V. Evaluación de dos métodos para medir la sensibilidad de inhibición de crecimiento de la cepa certificada de Staphylococcus aureus subsp. aureus. Rev Investig Vet del Peru [Internet]. 2018;29(4):1543-7. Disponible en: http://www.scielo.org.pe/pdf/rivep/v29n4/a52v29n4.pdf DOI: 10.15381/rivep.v29i4.15185

de Fuentes DR, da Silva RF. Actividad antimicrobiana in vitro del extracto foliar de zabila (Aloe vera L.) en microorganismos de interés clínico. Salus [Internet]. 2014;18(3):27-32. Disponible en: https://servicio.bc.uc.edu.ve/fcs/vol18n3/art05.pdf

Vélez E, D’Armas H, Jaramillo-Jaramillo C, Echavarría-Vélez AP, Isitua CC. Fitoquímica De Lippia Citriodora K cultivada en Ecuador y su actividad biológica. Cienc Unemi [Internet]. 2019;12(29):9-19. Disponible en: https://ojs.unemi.edu.ec/index.php/cienciaunemi/article/view/747 DOI: 10.29076/issn.2528-7737vol12iss29.2019pp9-19p

Upton R, David B, Gafner S, Glasl S. Botanical ingredient identification and quality assessment: strengths and limitations of analytical techniques. Phytochem Rev [Internet]. 2020;19(5):1157-77. Disponible en: https://doi.org/10.1007/s11101-019-09625-z DOI: 10.1007/s11101-019-09625-z

Sandoval Rangel A, Benavides Mendoza A, Alvarado Vázquez MA, Foroughbakhch Pournavab R, Núñez González MA, Robledo Torres V. Influencia de ácidos orgánicos sobre el crecimiento, perfil bromatológico y metabolitos secundarios en chile piquín. Terra Latinoam [Internet]. 2011;29(4):395-401. Disponible en: https://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S0187-57792011000400395

Wei J-N, Liu Z-H, Zhao Y-P, Zhao L-L, Xue T-K, Lan Q-K. Phytochemical and bioactive profile of Coriandrum sativum L. Food Chem [Internet]. 2019;286:260-7. Disponible en: https://www.sciencedirect.com/science/article/abs/pii/S030881461930250X?via%3Dihub DOI: 10.1016/j.foodchem.2019.01.171 PMID 30827604

Rojas-Angulo R, Yanez-Jara F, Márquez Hernández I, Campo-Fernández M. Evaluación farmacognóstica de hojas y extractos de Coriandrum sativum L. de diferentes procedencias. Cienc Unemi. 2020;13(33):73-84. Disponible en: https://ojs.unemi.edu.ec/index.php/cienciaunemi/article/view/1049/1095 DOI: 10.29076/issn.2528-7737vol13iss33.2020pp73-84p

Figliolo R, Besil N, Da Luz-Graña C, Martínez G, Porley G, Migues Borghini I, et al. Control de calidad preliminar de hierbas in natura comercializadas en Uruguay. Casos de estudio: manzanilla, marcela y tilo. INNOTEC [Internet]. 2023;(26):e643. Disponible en: https://ojs.latu.org.uy/index.php/INNOTEC/article/view/643 DOI: 10.26461/26.05

Oviedo JC, Casas AE, Valencia JA, García L. Evaluation of three variables of growth of Pleurotus pulmonarius on corncob using digital image processing. Inf Tecnol [Internet]. 2016;27(5):27-36. Disponible en: https://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-07642016000500004 DOI: 10.4067/S0718-07642016000500004

López-Medina EN, Álvarez-García R, Tellez-Jurado A, Aguayo-Rojas J, Tovar-Jiménez X. Análisis químico-proximal, fitoquímico y potencial bacteriostático de Eichhornia crassipes. Biotecnia [Internet]. 2022;24(2):36-44. Disponible en: https://biotecnia.unison.mx/index.php/biotecnia/article/view/1638 DOI: 10.18633/biotecnia.v24i2.1638

Monsalve-Paredes M, Bello-Alarcón A. Evaluación antimicrobiana de extractos obtenidos de los residuos de la corteza de Teca (Tectona grandis l.f). Cienc UNEMI [Internet]. 2020;13(32):63-8. Disponible en: https://doi.org/10.29076/issn.2528-7737vol13iss32.2020pp63-68p DOI: 10.29076/issn.2528-7737vol13iss32.2020pp63-68p

Petrovska BB. Historical review of medicinal plants' usage. Pharmacogn Rev. 2012;6(11):1-5. DOI: 10.4103/0973-7847.95849 PMID 22654398 PMCID PMC3358962

Torres-Aguirre G, Muñoz-Bernal Ó, Álvarez-Parrilla E, Núñez-Gastélum J, Wall-Medrano A, Sáyago-Ayerdi S. Optimization of the extraction and identification of polyphenolic compounds in aniseed (Pimpinella anisum), clove (Syzygium aromaticum) and coriander (Coriandrum sativum) through HPLC coupled to mass spectrometry. TIP Rev Espec en Ciencias Químico-Biológicas [Internet]. 2018;21(2):103-15. Disponible en: https://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S1405-888X2018000200103 DOI: 10.22201/fesz.23958723e.2018.2.4

Sieberi BM, Omwenga GI, Wambua RK, Samoei JC, Ngugi MP. Screening of the Dichloromethane: Methanolic Extract of Centella asiatica for Antibacterial Activities against Salmonella typhi, Escherichia coli, Shigella sonnei, Bacillus subtilis, and Staphylococcus aureus. Scientific World Journal [Internet]. 2020;2020:6378712. Disponible en: https://onlinelibrary.wiley.com/doi/10.1155/2020/6378712 DOI: 10.1155/2020/6378712 PMID 32694956 PMCID PMC7350070

Published
2025-10-26
How to Cite
1.
Jaramillo-Jaramillo CG, Ajila-Solórzano KE, Manzanares-Loaiza SG, Sorroza-Ochoa LS, Espinoza-Pluas G, Echavarria-Velez A-P. Antibacterial Activity of Culantro Leaves (Coriandrum sativum L.). Kasmera [Internet]. 2025Oct.26 [cited 2025Dec.5];53:e442721. Available from: https://produccioncientificaluz.org/index.php/kasmera/article/view/44272
Issue
Vol. 53 (2025)
Section
Original Articles

Copyright (c) 2025 Carmita Gladys Jaramillo-Jaramillo, Keyla Emilia Ajila-Solórzano, Silvana Gabriela Manzanares-Loaiza, Lita Scarlett Sorroza-Ochoa, Gerardo Espinoza-Pluas, Ana-Paola Echavarria-Velez

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

 

Kasmera journal is registered under a Creative Commons an Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0), available at: https://creativecommons.org/licenses/by-nc-sa/4.0/deed.en; which guarantees the freedom to share-copy and redistribute the material in any medium or format and adapt-remix, transform and build from the material, provided that the name of the authors, the Department of Infectious and Tropical Diseases, Zulia´s University and Kasmera Journal, you must also provide a link to the original document and indicate if changes have been made.

The Department of Infectious and Tropical Diseases, University of Zulia and Kasmera Journal do not retain the rights to published manuscript and the contents are the sole responsibility of the authors, who retain their moral, intellectual, privacy and publicity rights. The guarantee on the intervention of the manuscript (revision, correction of style, translation, layout) and its subsequent dissemination is granted through a license of use and not through a transfer of rights, which represents the Kasmera Journal and Department Infectious Diseases, University of Zulia are exempt from any liability that may arise from ethical misconduct by the authors.

Kasmera is considered a green SHERPA/RoMEO journal, that is, it allows self-archiving of both the pre-print (draft of a manuscript) and the post-print (the corrected and peer-reviewed version) and even the final version (layout as it will be published in the journal) both in personal repositories and in institutional and databases.