The Effect of Antiretroviral Therapy on the Lipid Profile of AIDS Patients in Maracaibo, State of Zulia, Venezuela

  • Isabel Soto Internal Medicine specialist
  • María Villalobos Faculty of Medicine, University of Zulia.
  • Rafael Villalobos Chair of Tropical Medicine, Faculty of Medicine, University of Zulia.
Keywords: AIDS, anti-retroviral therapy, lipidic profile

Abstract

A prospective study was carried out to determine the effect of antiretroviral therapy on the lipid profile in a population of 50 patients with AIDS who received their first antiretroviral drug treatment in the HIV-AIDS clinic at the Maracaibo University Hospital from November 2008 to July 2009. Serum levels of cholesterol, triglycerides, HDL-cholesterol and LDL-cholesterol were determined at the beginning and the end of the study. The therapeutic combinations were: 47 patients (94.0%) with the protease/booster inhibitors (IP/b) + nucleoside inhibitors of reverse transcriptase (NRTI) and 3 (6%)with 2NRTI + 1 non-nucleoside inhibitors of reverse transcriptase inhibitors (NNRTIs). Initially, lipid profile parameters were inside the range of normality. By the end of the study, blood levels for triglycerides, total cholesterol and LDLc had increased with regard to the initial values. Conclusions are that hypertriglyceridemia is a frequent alteration in patients that receive antiretroviral therapy with PI/b combined with NRTI, since this constituted most of the sample studied.

Published
2010-08-07
How to Cite
1.
Soto I, Villalobos M, Villalobos R. The Effect of Antiretroviral Therapy on the Lipid Profile of AIDS Patients in Maracaibo, State of Zulia, Venezuela. Kasmera [Internet]. 2010Aug.7 [cited 2024Dec.5];38(2):157-6. Available from: https://produccioncientificaluz.org/index.php/kasmera/article/view/4865
Issue
Vol. 38 No. 2 (2010)
Section
Original Articles

Copyright (c) 2010 Isabel Soto, María Villalobos, Rafael Villalobos

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Kasmera journal is registered under a Creative Commons an Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0), available at: https://creativecommons.org/licenses/by-nc-sa/4.0/deed.en; which guarantees the freedom to share-copy and redistribute the material in any medium or format and adapt-remix, transform and build from the material, provided that the name of the authors, the Department of Infectious and Tropical Diseases, Zulia´s University and Kasmera Journal, you must also provide a link to the original document and indicate if changes have been made.

The Department of Infectious and Tropical Diseases, University of Zulia and Kasmera Journal do not retain the rights to published manuscript and the contents are the sole responsibility of the authors, who retain their moral, intellectual, privacy and publicity rights. The guarantee on the intervention of the manuscript (revision, correction of style, translation, layout) and its subsequent dissemination is granted through a license of use and not through a transfer of rights, which represents the Kasmera Journal and Department Infectious Diseases, University of Zulia are exempt from any liability that may arise from ethical misconduct by the authors.

Kasmera is considered a green SHERPA/RoMEO journal, that is, it allows self-archiving of both the pre-print (draft of a manuscript) and the post-print (the corrected and peer-reviewed version) and even the final version (layout as it will be published in the journal) both in personal repositories and in institutional and databases.