Incidence of Herpes simplex Virus Infection in Patients with Acute Central Nervous System Infections

  • Kriss Pérez Regional Laboratory of Virological Reference. Faculty of Medicine. University of Zulia.
  • Leticia Porto Espinoza Regional Laboratory of Virological Reference. Faculty of Medicine. University of Zulia.
  • Raimy Mindiola Regional Laboratory of Virological Reference. Faculty of Medicine. University of Zulia.
  • Diana Callejas Regional Laboratory of Virological Reference. Faculty of Medicine. University of Zulia.
  • Jesús Estévez Institute of Clinical Research. Facukty of Medicine. University of Zulia.
  • Reyna Moronta Chair of Cell Biology and Genetics, Department of Biology, Faculty of Humanities and Education, Universidad del Zulia.
Keywords: Herpes viruses, meningitis, encephalitis, cerebrospinal fluid, antibodies

Abstract

Herpes simplex viruses are agents responsible for a variety of infections on buccal and genital mucosa; they are neurotropic, capable of lodging in the nerve cells and remaining latent with subsequent reactivations; in some cases, they can provoke meningitis and encephalitis; and they have a significant morbidity and are associated with a high mortality. The present project aims to determine HSV’s effect on the etiology of acute central nervous system (CNS) syndromes using the detection of specific antibodies in serum and cerebrospinal fluid. The 93 paired samples from patients with neurological affectations studied demonstrated negative results in the LCR bacteriological study and their Alb-LCR/Alb-serum relation was < 0.0075. Antibodies were detected by the enzymatic immunoassay ELISA method, where 1.2% (1/93) of the serum samples turned out positive for IgM; 89.24% (83/93) of the serum samples resulted positive for IgG; and 27.39% (20/93) of LCR samples were positive for anti-IgG. IgG presence in LCR suggested the intrathecal production of these antibodies inside the CNS, which demonstrates a significant participation by this viral agent in infections and diseases associated with the CNS.

Published
2010-08-07
How to Cite
1.
Pérez K, Porto Espinoza L, Mindiola R, Callejas D, Estévez J, Moronta R. Incidence of Herpes simplex Virus Infection in Patients with Acute Central Nervous System Infections. Kasmera [Internet]. 2010Aug.7 [cited 2024Nov.25];38(2):147-56. Available from: https://produccioncientificaluz.org/index.php/kasmera/article/view/4864
Issue
Vol. 38 No. 2 (2010)
Section
Original Articles

Copyright (c) 2010 Kriss Pérez, Leticia Porto Espinoza, Raimy Mindiola, Diana Callejas, Jesús Estévez, Reyna Moronta

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