Mechanisms of Resistance to Glycopeptides in Staphylococcus aureus

  • Maribel Castellano González Chair of General Bacteriology. School of Bioanalysis. University of Zulia.
  • Armindo Perozo Mena Chair of Professional Practice of Bacteriology. School of Bioanalysis. University of Zulia. Venezuela. Bacteriological Reference Center - Autonomous Service University Hospital of Maracaibo. Venezuela.
Keywords: Staphylococcus aureus, glycopeptides, vancomycin, teicoplanin, resistance mechanisms

Abstract

Glycopeptides (vancomycin and teicoplanin) are an alternative therapeutic in the treatment of severe infections by methicillin-resistant S. aureus strains. However, two resistance mechanisms of S. aureus have already been described: low-level resistance, characterized by an abnormal thickening of the cellular wall, present in the VISA strains, and high-level resistance, mediated by the vanA operon, which causes the replacement of D-ala - D-ala terminal residues by D-ala-D-lac, decreasing its affinity for the antibiotic. This review summarizes the history of the emergence of glycopeptide resistance in S. aureus and considers the mechanisms that determine the resistance in these organisms as a background for understanding the need and potential roles of new agents of this kind.

Published
2010-08-07
How to Cite
1.
Castellano González M, Perozo Mena A. Mechanisms of Resistance to Glycopeptides in Staphylococcus aureus. Kasmera [Internet]. 2010Aug.7 [cited 2024Nov.26];38(1):36-4. Available from: https://produccioncientificaluz.org/index.php/kasmera/article/view/4854
Issue
Vol. 38 No. 1 (2010)
Section
Narrative Review

Copyright (c) 2010 Maribel Castellano González, Armindo Perozo Mena

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