Prevalence of cases of positive antigen against SARS-COV-2 in patients treated in a clinical laboratory in the Maracaibo municipality, period 2020-2021
Abstract
The correct and rapid diagnosis of SARS-CoV-2 infection is crucial from both epidemiological and clinical perspectives. The aim was to determine the prevalence of positive cases of SARS-CoV-2 antigen in patients treated at a clinical laboratory in the municipality of Maracaibo, during the period 2020-2021. A total of 344 nasopharyngeal swabs were taken from patients with symptoms suggestive of infection, with less than 5 days of evolution, who visited the clinical laboratory between September 2020 and August 2021. The detection of SARS-CoV-2 antigen was performed using a rapid test (PANBIO™ COVID-19 Ag Rapid Test Device). A prevalence of positive cases of SARS-CoV-2 antigen of 62.51% was obtained. The most affected age group was between 31-50 years with 52.09%, followed by 51-70 years, 24.18%. Males predominated among the positive cases with 57.67%. Regarding the presence of symptoms, the most prevalent were headache with 58.13% and sore throat with 52.55%. COVID-19 remains present, although it appears stable; however, it has not ceased to be a threat to global health, highlighting the importance of maintaining surveillance to make timely decisions
References
Castañeda Guillot C, Ramos Serpa G. Principales pandemias en la historia de la humanidad. Rev Cubana Pediatr [Internet]. 2020;92. Disponible en: https://revpediatria.sld.cu/index.php/ped/article/view/1183
Gotera J, Linares J. COVID -19. La pandemia en Venezuela. Investig y Desarro [Internet]. 2020;13(1):80. Disponible en: https://revistasuta.com/index.php/dide/article/view/1007 DOI: 10.31243/id.v13.2020.1007
Tangarife Tangarife LX, Vergara Castro J, Jaramillo Agudelo MC, Mejía Valencia T, Varón Ramírez CP. Prevalencia de infección por SARS-CoV-2 en el personal de enfermería del hospital Santa Mónica del municipio de Dosquebradas 2020 y 2021. Cult del Cuid [Internet]. 2023;20(2):102-19. Disponible en: https://enfispo.es/servlet/articulo?codigo=9128351
OPS. Se acaba la emergencia por la pandemia, pero la COVID-19 continúa. 6 de mayo de 2023. Disponible en: https://www.paho.org/es/noticias/6-5-2023-se-acaba-emergencia-por-pandemia-pero-covid-19-continua
Wang W, Xu Y, Gao R, Lu R, Han K, Wu G, et al. Detection of SARS-CoV-2 in Different Types of Clinical Specimens. JAMA [Internet]. 2020;323(18):1843-4. Disponible en: https://jamanetwork.com/journals/jama/fullarticle/2762997 DOI: 10.1001/jama.2020.3786 PMID 32159775 PMCID PMC7066521
Yong G, Yi Y, Tuantuan L, Xiaowu W, Xiuyong L, Ang L, et al. Evaluation of the auxiliary diagnostic value of antibody assays for the detection of novel coronavirus (SARS-CoV-2). J Med Virol [Internet]. 2020;92(10):1975-9. Disponible en: https://onlinelibrary.wiley.com/doi/10.1002/jmv.25919 DOI: 10.1002/jmv.25919 PMID 32320064 PMCID PMC7264661
Estrategia de detección precoz, vigilancia y control de COVID-19. Centro de Coordinación de Alertas y Emergencias Sanitarias. Ministerio de Sanidad. Actualizado 22 de diciembre de 2021. Disponible en: https://www.sanidad.gob.es/profesionales/saludPublica/ccayes/alertasActual/nCov/documentos/COVID19_Estrategia_vigilancia_y_control_e_indicadores.pdf
European Centre for Disease Prevention and Control: Options for the use of rapid antigen tests for COVID-19 in the EU/EEA and the UK; 19 November 2020. Disponible en: https://www.ecdc.europa.eu/en/publications-data/options-use-rapid-antigentests-covid-19-eueea-and-uk
Centers for Disease Control and Prevention (CDC). Interim Guidance for Antigen Testing for SARS-CoV-2. Updated May 11, 2023. Disponible en: https://www.cdc.gov/coronavirus/2019-ncov/lab/resources/antigen-tests-guidelines.html
Albert E, Torres I, Bueno F, Huntley D, Molla E, Fernández-Fuentes MÁ, et al. Field evaluation of a rapid antigen test (PanbioTM COVID-19 Ag Rapid Test Device) for COVID-19 diagnosis in primary healthcare centres. Clin Microbiol Infect [Internet]. 2021;27(3):472.e7-472.e10. Disponible en: https://www.clinicalmicrobiologyandinfection.org/article/S1198-743X(20)30697-2/fulltext DOI 10.1016/j.cmi.2020.11.004 PMID 33189872 PMCID PMC7662075
Linares M, Pérez-Tanoira R, Carrero A, Romanyk J, Pérez-García F, Gómez-Herruz P, et al. Panbio antigen rapid test is reliable to diagnose SARS-CoV-2 infection in the first 7 days after the onset of symptoms. J Clin Virol [Internet]. 2020;133:104659. Disponible en: https://www.sciencedirect.com/science/article/pii/S1386653220304017?via%3Dihub DOI 10.1016/j.jcv.2020.104659 PMID 33160179 PMCID PMC7561603
Fenollar F, Bouam A, Ballouche M, Fuster L, Prudent E, Colson P, et al. Evaluation of the Panbio COVID-19 Rapid Antigen Detection Test Device for the Screening of Patients with COVID-19. J Clin Microbiol [Internet]. 2021;59(2):e02589-20. Disponible en: https://journals.asm.org/doi/10.1128/jcm.02589-20?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed DOI: 10.1128/JCM.02589-20 PMID 33139420 PMCID PMC8111145
Panunzio P, Castellano M, Villarroel F, Perozo A, Costa-Leon L, Añez J. Casos de antígeno de SARS-COV-2 positivo. Laboratorio clínico de la Escuela de Bioanálisis de la Universidad del Zulia. En: IX Congreso Científico Internacional de la Facultad de Medicina “Dr Orlando Castejón” [Internet]. Maracaibo-Zulia; 2022. p. 541. Disponible en: https://produccioncientificaluz.org/index.php/investigacion/article/view/38509/42772
Clark A, Jit M, Warren-Gash C, Guthrie B, Wang HHX, Mercer SW, et al. Global, regional, and national estimates of the population at increased risk of severe COVID-19 due to underlying health conditions in 2020: a modelling study. Lancet Glob Heal [Internet]. 2020;8(8):e1003-17. Disponible en: https://www.thelancet.com/journals/langlo/article/PIIS2214-109X(20)30264-3/fulltext DOI: 10.1016/S2214-109X(20)30264-3 PMID 32553130 PMCID PMC7295519
Xie J, Tong Z, Guan X, Du B, Qiu H. Clinical Characteristics of Patients Who Died of Coronavirus Disease 2019 in China. JAMA Netw open [Internet]. 2020;3(4):e205619. Disponible en: https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2764293 DOI: 10.1001/jamanetworkopen.2020.5619 PMID 32275319 PMCID PMC7148440
Takahashi T, Ellingson MK, Wong P, Israelow B, Lucas C, Klein J, et al. Sex differences in immune responses that underlie COVID-19 disease outcomes. Nature [Internet]. 2020;588(7837):315-20. Disponible en: https://www.nature.com/articles/s41586-020-2700-3 DOI: 10.1038/s41586-020-2700-3 PMID 32846427 PMCID PMC7725931
Gandhi RT, Lynch JB, Del Rio C. Mild or Moderate Covid-19. N Engl J Med [Internet]. 2020;383(18):1757-66. Disponible en: https://www.nejm.org/doi/full/10.1056/NEJMcp2009249. DOI: 10.1056/NEJMcp2009249 PMID 32329974
Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet [Internet]. 2020;395(10229):1054-62. Disponible en: https://doi.org/10.1016/S0140-6736(20)30566-3 DOI 10.1016/S0140-6736(20)30566-3 PMID 32171076 PMCID PMC7270627
Copyright (c) 2025 María Claret Robertis Colmenares, Amelia Patricia Patricia Rodríguez, Jennifer Lucila Gotera Zambrano

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Kasmera journal is registered under a Creative Commons an Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0), available at: https://creativecommons.org/licenses/by-nc-sa/4.0/deed.en; which guarantees the freedom to share-copy and redistribute the material in any medium or format and adapt-remix, transform and build from the material, provided that the name of the authors, the Department of Infectious and Tropical Diseases, Zulia´s University and Kasmera Journal, you must also provide a link to the original document and indicate if changes have been made.
The Department of Infectious and Tropical Diseases, University of Zulia and Kasmera Journal do not retain the rights to published manuscript and the contents are the sole responsibility of the authors, who retain their moral, intellectual, privacy and publicity rights. The guarantee on the intervention of the manuscript (revision, correction of style, translation, layout) and its subsequent dissemination is granted through a license of use and not through a transfer of rights, which represents the Kasmera Journal and Department Infectious Diseases, University of Zulia are exempt from any liability that may arise from ethical misconduct by the authors.
Kasmera is considered a green SHERPA/RoMEO journal, that is, it allows self-archiving of both the pre-print (draft of a manuscript) and the post-print (the corrected and peer-reviewed version) and even the final version (layout as it will be published in the journal) both in personal repositories and in institutional and databases.









_pequeño1.png)

_pequeña.png)









_pequeña.png)




_pequeña.jpg)


