Antibodies against dengue virus in patients with dislipidemias

Keywords: dengue, dyslipidemia, immunity, antibodies

Abstract

The objective was to compare the antibodies against the dengue virus in patients with different types of dyslipidemias. Type of descriptive, prospective study of non-experimental, crosssectional design. The sample consisted of 214 individuals, distributed in 169 with dyslipidemias and 45 controls. Serum lipids and anti-dengue antibodies were determined by conventional biochemical and immunological methods. They were classified into 3 groups: hypertriacilgliceridemia (279.7 ± 84.2 mg / dl); hypercholesterolemia (252.7 ± 38.5 mg / dl) and the group with high triglycerides and cholesterol (257.3 ± 38.5, 271.6 ± 88.7 mg / dl). 96% of the patients showed immunity (IgG) against dengue virus, the primary response (IgM) was present in 22%. Regarding the positivity of IgM, the highest frequency was in the group with hypertriacilgliceridemia (34.2%), while the frequency for IgG was in the group with triacylglycerides and high cholesterol (31.2%). In this study, no difference was observed between IgG and IgM antibodies against dengue virus in patients with dyslipidemia and the control group. Future studies are needed to demonstrate in areas of lower endemicity for the dengue virus if, in fact, the alteration of the lipid profile modifies the intensity of response to the infection.

References

Strating JR, van Kuppeveld FJ. Viral rewiring of cellular lipid metabolism to create membranous replication compartments. Curr Opin Cell Biol [Internet]. 2017;47:24-33. Disponible en: https://linkinghub.elsevier.com/retrieve/pii/S0955067416301594 DOI: 10.1016/j.ceb.2017.02.005 PMID 28242560 Google Académico

Jordan TX, Randall G. Flavivirus modulation of cellular metabolism. Current Opinion in Virology [Internet]. 2016:19:7-10. Disponible en: http://linkinghub.elsevier.com/retrieve/pii/S187962571630058X DOI: 10.1016/j.coviro.2016.05.007 PMID 27280383 PMCID PMC5021554 Google Académico

Ahmed S, Finkelstein JL, Stewart AM, Kenneth J, Polhemus ME, Endy TP, et al. Review article: Micronutrients and dengue. Am J Trop Med Hyg [Internet]. 2014;91(5):1049-56. Disponible en: http://www.ncbi.nlm.nih.gov/pubmed/25200269 DOI: 10.4269/ajtmh.14-0142 PMID 25200269 PMCID PMC4228873 Google Académico

Biswas HH, Gordon A, Nuñez A, Perez MA, Balmaseda A, Harris E. Lower Low-Density Lipoprotein Cholesterol Levels Are Associated with Severe Dengue Outcome. PLoS Negl Trop Dis [Internet]. 2015;9(9):e0003904. Disponible en: http://dx.plos.org/10.1371/journal.pntd.0003904 DOI: 10.1371/journal.pntd.0003904 PMID 26334914 PMCID PMC4559460 Google Académico

Durán A, Carrero R, Parra B, González A, Delgado L, Mosquera J, et al. Association of lipid profile alterations with severe forms of dengue in humans. Arch Virol [Internet]. 2015;160(7):1687-92. Disponible en: http://link.springer.com/10.1007/s00705-015-2433-z DOI 10.1007/s00705-015-2433-z PMID 25936955 Google Académico

van Gorp ECM, Suharti C, Mairuhu ATA, Dolmans WM V, van der Ven J, Demacker PNM, et al. Changes in the Plasma Lipid Profile as a Potential Predictor of Clinical Outcome in Dengue Hemorrhagic Fever. Clin Infect Dis [Internet]. 2002;34(8):1150-3. Disponible en: https://academic.oup.com/cid/article-lookup/doi/10.1086/339539 DOI 10.1086/339539 PMID 11915007 Google Académico

Chuck A. Lipid Profile Changes as a Potential Prognostic Marker for the Prediction of Dengue Fever Severity in Pediatric Patients. [Master of Science in Physician Assistant Studies]. Hillsboro, OR: Pacific University Oregon. School of Physician Assistant Studies. 2017. Disponible en: https://commons.pacificu.edu/pa/603 Google Académico

Villareal VA, Rodgers MA, Costello DA, Yang PL. Targeting host lipid synthesis and metabolism to inhibit dengue and hepatitis C viruses. Antiviral Res [Internet]. 2015;124:110-21. Disponible en: https://www.sciencedirect.com/science/article/pii/S0166354215300140?via%3Dihub DOI 10.1016/j.antiviral.2015.10.013 PMID 26526588 PMCID PMC4699661 Google Académico

Friedewald WT, Levy RI, Fredrickson DS. Estimation of the Concentration of Low-Density Lipoprotein Cholesterol in Plasma. Clin Chem [Internet]. 1972;18(6):499-502. Disponible en: http://clinchem.aaccjnls.org/content/18/6/499.long PMID 4337382 Google Académico

U.S. Department of Health and Human Services. ATP III At-A-Glance: Quick Desk Reference-NHLBI, NIH [Internet]. National Heart, Lung and Blood Institute. 2001 [citado 1 de mayo de 2019]. Disponible en: https://www.nhlbi.nih.gov/health-topics/all-publications-and-resources/atp-iii-glance-quick-desk-reference

Kuhn RJ, Zhang W, Rossmann MG, Pletnev S V, Corver J, Lenches E, et al. Structure of dengue virus: Implications for flavivirus organization, maturation, and fusion. Cell [Internet]. 2002;108(5):717-25. Disponible en: https://www.cell.com/cell/fulltext/S0092-8674(02)00660-8?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867402006608%3Fshowall%3Dtrue DOI 10.1016/S0092-8674(02)00660-8 PMID 11893341 PMCID PMC4152842 Google Académico

Yu IM, Zhang W, Holdaway HA, Li L, Kostyuchenko VA, Chipman PR, et al. Structure of the immature dengue virus at low pH primes proteolytic maturation. Science [Internet]. 2008;319(5871):1834-7. Disponible en: http://www.sciencemag.org/cgi/doi/10.1126/science.1153264 DOI 10.1126/science.1153264 PMID 18369148 Google Académico

Chen Y, Maguire T, Hileman RE, Fromm JR, Esko JD, Linhardt RJ, et al. Dengue virus infectivity depends on envelope protein binding to target cell heparan sulfate. Nat Med [Internet]. 1997;3(8):866-71. Disponible en: http://www.nature.com/articles/nm0897-866 DOI 10.1038/nm0897-866 PMID 9256277 Google Académico

Cambi A, De Lange F, Van Maarseveen NM, Nijhuis M, Joosten B, Van Dijk EMHP, et al. Microdomains of the C-type lectin DC-SIGN are portals for virus entry into dendritic cells. J Cell Biol [Internet]. 2004;164(1):145-55. Disponible en: http://www.jcb.org/lookup/doi/10.1083/jcb.200306112 DOI 10.1083/jcb.200306112 PMID 14709546 Google Académico

Puerta-Guardo H, Mosso C, Medina F, Liprandi F, Ludert JE, del Angel RM. Antibody-dependent enhancement of dengue virus infection in U937 cells requires cholesterol-rich membrane microdomains. J Gen Virol [Internet]. 2010;91(2):394-403. Disponible en: https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.015420-0 DOI 10.1099/vir.0.015420-0 PMID 19828759 Google Académico

Acosta EG, Kumar A, Bartenschlager R. Revisiting dengue virus-host cell interaction: New insights into molecular and cellular virology. En: Maramorosch K, Murphy F, editors. Advances in Virus Research [Internet]. Vol 88. San Diego, CA:Academic Press; 2014. p. 1-109. Disponible en: https://linkinghub.elsevier.com/retrieve/pii/B9780128000984000015 DOI 10.1016/B978-0-12-800098-4.00001-5 PMID 24373310 Google Académico

Perera R, Riley C, Isaac G, Hopf-Jannasch AS, Moore RJ, Weitz KW, et al. Dengue virus infection perturbs lipid homeostasis in infected mosquito cells. PLoS Pathog [Internet]. 2012;8(3):e1002584. Disponible en: https://dx.plos.org/10.1371/journal.ppat.1002584 DOI 10.1371/journal.ppat.1002584 PMID 22457619 PMCID PMC3310792 Google Académico

Villar Centeno LA, Quijano Diaz FA, Martínez Vega RA. Evaluación de Marcadores Bioquímicos como Predictores de Dengue Hemorrágico. Salud IUS [Internet]. 2005;37(2):102-6. Disponible en: https://revistas.uis.edu.co/index.php/revistasaluduis/article/view/555 Google Académico

Suvarna JC, Rane PP. Serum lipid profile: A predictor of clinical outcome in dengue infection. Trop Med Int Heal [Internet]. 2009;14(5):576-85. Disponible en: http://doi.wiley.com/10.1111/j.1365-3156.2009.02261.x DOI 10.1111/j.1365-3156.2009.02261.x PMID 19309479 Google Académico

Valero N, Quiroz Y. Is the fight against dengue complicated with the emergence of a new viral serotype? Investig Clin [Internet]. 2014;55(3):203-5. Disponible en: http://www.ncbi.nlm.nih.gov/pubmed/25272519 PMID 25272519 Google Académico

Durán A, Ochoa E, Alcocer S, Gómez M, Millano M, Martínez O, et al. Frecuencia de signos y síntomas gastrointestinales del dengue. Análisis de una cohorte de 1484 pacientes. Invest Clin [Internet]. 2013;54(3):299-310. Disponible en: http://www.ncbi.nlm.nih.gov/pubmed/24354243 PMID 24354243 Google Académico

Linares S, Bermúdez V, Rojas J, González R, Torres W, Mejias J, et al. Prevalencia de dislipidemias y factores psicobiológicos asociados en individuos adultos del municipio Maracaibo, Venezuela. Síndrome Cardiometabólico [Internet]. 2015;3(3):63-75. Disponible en: http://saber.ucv.ve/ojs/index.php/rev_sc/article/view/9507 Google Académico

Nuñez M, Rojas J, Torres W, González R, Mejías JC, Olivar LC, et al. Características sociodemográficas asociadas a dislipidemia en el estudio de prevalencia de síndrome metabólico de Maracaibo, Venezuela. Rev Latinoam Hipertens [Internet]. 2013;8(4):77-89. Disponible en: https://www.redalyc.org/articulo.oa?id=170231793001 Google Académico

Published
2019-12-01
How to Cite
1.
Gotera J, Valero-Cedeño NJ, Avila-Leal A, Linares J, Mosquera J, Bermúdez V, Veliz T. Antibodies against dengue virus in patients with dislipidemias. Kasmera [Internet]. 2019Dec.1 [cited 2024Nov.24];47(2):131-7. Available from: https://produccioncientificaluz.org/index.php/kasmera/article/view/29647
Issue
Vol. 47 No. 2 (2019)
Section
Original Articles

Copyright (c) 2019 Jennifer Gotera, Nereida Josefina Valero-Cedeño, Ayari Avila-Leal, Johan Linares, Jesús Mosquera, Valmore Bermúdez, Teresa Veliz

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