Clindamycin Resistance Induced by Erythromycin in Strains of Staphylococcus Aureus of Clinical Origin

  • Maribel Castellano General Bacteriology, School of Bioanalysis, Faculty of Medicine, University of Zulia
  • Armindo Perozo Bacteriology Professional Practice, School of Bioanalysis, Faculty of Medicine, University of Zulia
  • Mariheddy Molero General Bacteriology, School of Bioanalysis, Faculty of Medicine, University of Zulia
  • Sinead Montero General Bacteriology, School of Bioanalysis, Faculty of Medicine, University of Zulia
  • Francisco Primera General Bacteriology, School of Bioanalysis, Faculty of Medicine, University of Zulia
Keywords: Clindamycin, inducible resistance, erythromycin, Staphylococcus aureus

Abstract

Staphylococcus aureus is an important pathogen involved in a series of infections whose impact is increased by its multiple factors of virulence and antimicrobial resistance. Erythromycininduced clindamycin resistance is a growing problem in various parts of the world. This study was retrospective and analyzed the behavior in response to antimicrobials of 4307 strains of Staphylococcus aureus isolated in a hospital in the city of Maracaibo between January 2006 and December 2013. The frequency of erythromycin-induced clindamycin resistance, its association with resistance to oxacillin and the biological origin of the samples from which the microorganism was isolated were determined. Susceptibility to oxacillin was checked by diffusion method with disk agar and the induced clindamycin resistance was evaluated using the D-test. 60 D-Test positive strains were detected (1.39%), of which 38 (63.33%) were sensitive to methicillin and 22 strains were resistant (36.67%. The total resistance to clindamycin (constitutive and induced) represented 31.43% (1354) of the total number of strains tested. The frequency of induced resistance to clindamycin in Staphylococcus aureus strains in the locality is still low for both methicillin sensitive and resistant strains.

Published
2015-09-25
How to Cite
1.
Castellano M, Perozo A, Molero M, Montero S, Primera F. Clindamycin Resistance Induced by Erythromycin in Strains of Staphylococcus Aureus of Clinical Origin. Kasmera [Internet]. 2015Sep.25 [cited 2024Jul.20];43(1):34-5. Available from: https://produccioncientificaluz.org/index.php/kasmera/article/view/20069
Issue
Vol. 43 No. 1 (2015)
Section
Original Articles

Copyright (c) 2015 Maribel Castellano, Armindo Perozo, Mariheddy Molero, Sinead Montero, Francisco Primera

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