Impacto de la elastografía transitoria en el manejo de la hepatitis viral crónica

Impact of transient elastography in the management of chronic viral hepatitis

• Roberto León B. Instituto Médico La Floresta. Caracas, Venezuela https://orcid.org/0000-0002-8882-7787

DOI: https://doi.org/10.5281/zenodo.6709416

Keywords: hepatitis B virus, hepatitis C virus, fibrosis, cirrhosis

Abstract

Chronic infection by hepatitis B and C viruses (HBV and HCV) through their action on hepatocytes, cholangiocytes, Kupfer cells and lymphocytes-neutrophils leads to the generation of different mediators (TNF-α, TGF-β, PDGF ), which promote the   differentiation of hepatic stellate cells to activated myofibroblasts, which are responsible for the generation of abnormal deposits of collagen I and II, proteinglycans and hyaluronic acid, in a process known as fibrosis, which to the extent that is perpetual, leads to the appearance of cirrhosis, from which moment the possibility of developing portal  hypertension, liver failure and hepatocarcinoma increases significantly.

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