Clubfoot in guinea pigs (Cavia porcellus). Case report

• Medali Cueva-Rodríguez Universidad Nacional de Cajamarca, Facultad de Ciencias Veterinarias, Laboratorio de Patología Veterinaria, Cajamarca, Perú. https://orcid.org/0000-0002-1301-5477
• Jorge Portal-Torres Universidad Nacional de Cajamarca, Facultad de Ciencias Veterinarias, Laboratorio de Patología Veterinaria, Cajamarca, Perú. https://orcid.org/0000-0002-0334-9975
• Lizbeth Zambrano Universidad Nacional de Cajamarca, Facultad de Ciencias Veterinarias, Laboratorio de Patología Veterinaria, Cajamarca, Perú. https://orcid.org/0000-0002-4920-7833

DOI: https://doi.org/10.52973/rcfcv-e361784

Keywords: Clubfoot, congenital malformation, Cavia porcellus, Cajamarca

Abstract

Clubfoot, or talipes equinovarus, is a rare congenital malformation in small species such as guinea pigs (Cavia porcellus). A case is reported of a three-month-old female guinea pig presenting medial deviation of the forelimbs, without apparent systemic involvement. This condition is associated with intrauterine mechanical factors, neurological defects, genetic alterations, or interruptions in fetal development. The finding is relevant due to the scarcity of reports in guinea pigs, in contrast to cattle, sheep, and dogs. This report contributes to the clinical description and etiopathogenic discussion of clubfoot in small species, further highlighting the value of guinea pigs as a biomedical model for the analysis of congenital malformations.

References

Dobbs MB, Gurnett CA. Update on Clubfoot: Etiology and Treatment. Clin. Orthop. Relat. Res. [Internet]. 2009; 467(5):1146–1153. doi: https://doi.org/ccw9qx DOI: https://doi.org/10.1007/s11999-009-0734-9

Zionts LE, Dietz FR. Bracing Following Correction of Idiopathic Clubfoot Using the Ponseti Method. J. Am. Acad. Orthop. Surg. [Internet]. 2010;18(8):486–493. doi: https://doi.org/f3wckf DOI: https://doi.org/10.5435/00124635-201008000-00005

Tickle, C. How the embryo makes a limb: determination, polarity and identity. J. Anat. 2015; 227(4):418-430. doi: https://doi.org/f7q52s DOI: https://doi.org/10.1111/joa.12361

Pavone V, Chisari E, Vescio A, Lucenti L, Sessa G, Testa G. The etiology of idiopathic congenital talipes equinovarus: a systematic review. J. Orthop. Surg. Res. [Internet]. 2018; 13(1):206. doi: https://doi.org/gd468z DOI: https://doi.org/10.1186/s13018-018-0913-z

Collinson JM, Lindström NO, Neves C, Wallace K, Meharg C, Charles RH, Ross ZK, Fraser AM, Mbogo I, Oras K, Nakamoto M, Barker S, Duce S, Miedzybrodzka Z, Vargesson N. The developmental and genetic basis of 'clubfoot' in the peroneal muscular atrophy mutant mouse. Dev. [Internet]. 2018; 145(3):dev160093. doi: https://doi.org/gc2k5r DOI: https://doi.org/10.1242/dev.160093

Dobbs, MB. Gurnett, C. A. Genetics of clubfoot. J. Pediatr. Orthop. B. [Internet]. 2012; 21(1):7-9. doi: https://doi.org/dgk8cs DOI: https://doi.org/10.1097/BPB.0b013e328349927c

Vega-Vilca JF, Maguiña-Maza RM, Cipriano-Bautista JG, Vega-Cadillo CA. Modelos no lineales para la descripción del crecimiento de cuyes (Cavia porcellus) de saca temprana. Rev. Investig. Vet. Perú. [Internet]. 2023; 34(4):e24409. doi: https://doi.org/qmvs DOI: https://doi.org/10.15381/rivep.v34i4.24409

Fossum TW. Small Animal Surgery. 5th ed. St Louis, Missouri, USA: Elsevier; 2018.

Piermattei DL, Flo GL, DeCamp CE. Handbook of small animal orthopedics and fracture repair. 4th ed. St. Louis, Missouri, USA: Saunders Elsevier; 2006.

Quesenberry KE, Donnelly TM, Mans C. Biology, husbandry, and clinical techniques of guinea pigs and chinchillas. In: Quesenberry KE, Carpenter JW, editors. Ferrets, Rabbits, and Rodents: Clinical Medicine and Surgery. 3rd ed. St. Louis, Misuri, USA: Elsevier Saunders; 2012. p. 279–294. DOI: https://doi.org/10.1016/B978-1-4160-6621-7.00022-1

Chauca de Zaldívar L. Producción de cuyes (Cavia porcellus). La Molina, Perú: Estudio FAO Produccion y Sanidad Animal 138; 1997.

Cole JB, Baes CF, Eaglen SAE, Lawlor TJ, Maltecca C, Ortega, VanRaden P. Invited review: Management of genetic defects in dairy cattle populations. J. Dairy Sci. [Internet]. 2025; 108(4):3045–3067. doi: https://doi.org/qmvv DOI: https://doi.org/10.3168/jds.2024-26035

Usca-Méndez J, Flores-Mancheno L, Tello-Flores L, Navarro-Ojeda M. Manejo general en la cría del cuy. Riobamba, Ecuador. Escuela Superior Politécnica de Chimborazo, Dirección de Publicaciones; 2022.

Anzaldúa-Arce SR, Hernández-Espinosa J, Ocadiz-Tapia R, Villaseñor-Gaona H, Fouilloux-Morales A. Biología Tisular Veterinaria: descripción histológica de tejidos y órganos. 1ª ed. México: Universidad Nacional Autónoma de México; 2021. DOI: https://doi.org/10.22201/fmvz.9786073047715e.2021

Basit S, Khoshhal KI. Genetics of clubfoot: Recent progress and future perspectives. Eur. J. Med. Genet. [Internet]. 2018; 61(2):107–113. doi: https://doi.org/mtpq DOI: https://doi.org/10.1016/j.ejmg.2017.09.006

Dennis SM. Congenital defects of sheep. Vet. Clin. North Am. Food Anim. Pract. [Internet]. 1993; 9(1):203-217. doi: https://doi.org/qmv3 DOI: https://doi.org/10.1016/S0749-0720(15)30681-2