Correlation of PaO2/FiO2, SaO2/FiO2 and SpO2/FiO2 in healthy canines located at high altitude
Abstract
Arterial oxygen pressure (PaO2) decreases with increasing altitude above sea level; therefore, the expected values of arterial oxygen saturation (SaO2) and other PaO2–dependent respiratory indices change with altitude, as well as peripheral oxygen saturation (SpO2). Currently there are few published data on lung function indices in the clinical setting of canines living at high altitude while breath fraction of inspired oxygen (FiO2) of 21 %. This study aimed to identify PaO2/FiO2 (PF), SaO2/FiO2 (SF) and SpO2/FiO2 (SPF) values and their correlation, in a sample of healthy canines living at 2567 masl. Arterial gas and pulse oximetry data were collected in 17 clinically healthy canines. Arterial samples were collected 5 to 10 min after administration of intravenous acepromazine at 0.025 mg·kg-1. Mean PaO2 values of 67 ± 6.87 mmHg and 91.67 ± 2.33 % and 90.41 ± 3.92 % were identified for SaO2 and SpO2, respectively. For the PF, SF and SPF indices, values of 319.08 ± 32.71, 436.53 ± 11.1 and 430.53 ± 18.67 were obtained, respectively. The correlation between PF and SF was good (r: 0.94; P=0.0001) and between PF and SPF was weak (r: 0.35; P=0.16). In conclusion, the values of the PF, SF and SPF indices are lower than the values previously reported at low altitude. It is suggested that the altitude above sea level, the degree of hypoxemia and the pulse oximetry technique may affect the correlation between PF and SPF.
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