Pancreatic panniculitis and glomerulopathy in a Pomeranian dog. Clinical case
Abstract
A 10–year–old Pomeranian with chronic ulcerative and bullous lesions, that did not respond to previous treatment with amoxicillin, cephalexin, levothyroxine and trilostane, was presented. A primary immune–mediated process was suspected on examination, and multifocal superficial pyoderma was identified. A skin biopsy revealed panniculitis of pancreatic or sterile nodular origin. Further tests confirmed that the dog had ongoing pancreatitis and glomerulopathy. Ultrasonography revealed enlargement of the pancreatic tissue and hyperechogenicity. Treatment with cyclosporine, tetracycline, niacinamide and omega–3 for 8 weeks resulted in a favorable response. However, 4 weeks after clinical improvement of the skin, the dog suddenly became paraplegic and lost deep nociception. Spinal cord compression type Acute Non–compressive Nucleus Pulposus Extrusion (ANNPE) was suspected, but could not be confirmed. This case documents the presentation of pancreatic panniculitis in a Pomeranian and the concomitant occurrence of possibly associated glomerulopathy and spinal cord trauma.
Downloads
References
Mellanby RJ, Stell A, Baines E, Chantrey JC, Herrtage ME. Panniculitis associated with pancreatitis in a cocker spaniel. J. Small Anim. Pract. [Internet] 2003; 44(1):24–28. doi: https://doi.org/dk4vm4
Helton Rhodes K. Chapter 19 – Panniculitis. In: Helton Rhodes K, Werner A, editors. Blackwell’s Five–minute veterinary consult clinical companion: small animal dermatology. 2nd ed. West Sussex (UK): John Wiley & Son; 2018. p. 197–202.
Torres SM. Sterile nodular dermatitis in dogs. Vet. Clin. North Am. Small Anim. Pract [Internet]. 1999; 29(6):1311–1323. doi: https://doi.org/g8vnkh
German AJ, Foster AP, Holden D, Hotston–Moore A, Day MJ, Hall EJ. Sterile nodular panniculitis and pansteatitis in three weimaraners. J. Small Anim. Pract. [Internet]. 2003; 44(10):449–455. doi: https://doi.org/bwz9fc
Harvey RG, McKeever PJ. Sección 2 – Dermatosis nodulares: Paniculitis. In: Harvey RG, McKeever PJ, editors. Manual ilustrado de enfermedades de la piel en perro y gato. Madrid (España): Grass editions; 2006. p. 66–67.
Mellor PJ, Fetz K, Maggi RG, Haugland S, Dunning M, Villiers EJ, Mellanby RJ, Williams D, Breitschwerdt E, Herrtage ME. Alpha1–proteinase inhibitor deficiency and Bartonella infection in association with panniculitis, polyarthritis, and meningitis in a dog. J. Vet. Intern. Med. 2006; 20(4):1023–1028. doi: https://doi.org/d2cq33
O’Kell AL, Inteeworn N, Diaz SF, Saunders GK, Panciera DL. Canine sterile nodular panniculitis: A retrospective study of 14 cases. J. Vet. Intern. Med. [Internet]. 2010; 24(2):278–284. doi: https://doi.org/d3xvc9
Yamagishi C, Momoi Y, Kobayashi T, Ide K, Ohno K, Tsujimoto H, Iwasaki T. A retrospective study and gene analysis of canine sterile panniculitis. J. Vet. Med. Sci. [Internet]. 2007; 69(9):915–924. doi: https://doi.org/bqjnnz
Gear RNA, Bacon NJ, Langley–Hobbs S, Watson PJ, Woodger N, Herrtage ME. Panniculitis, polyarthritis and osteomyelitis associated with pancreatic neoplasia in two dogs. J. Small Anim. Pract. [Internet]. 2006; 47(7):400–404. doi: https://doi.org/bzmt67
Moreau PM, Fiske RA, Lees GE, Corrier DE. Disseminated necrotizing panniculitis and pancreatic nodular hyperplasia in a dog. J. Am. Vet. Med. Assoc. [Internet]. 1982 [cited 6 Aug. 2024]; 180(4):422–425. PMID: 7061328. Available in: https://goo.su/Vd0AH
Kunovsky L, Dite P, Brezinova E, Sedlakova L, Trna J, Jabandziev P. Skin manifestations of pancreatic diseases. Biomed Pap .[Internet]. 2022; 166(4):353–358. doi: https://doi.org/g8vnkj
Brown PJ, Mason KV, Merrett DJ, Mirchandani S, Miller RI. Multifocal necrotizing steatites associated with pancreatic carcinoma in three dogs. J. Small Anim. Pract. [Internet]. 1994; 35(3):129–132. doi: https://doi.org/fgj4xr
Hughes D, Goldschmidt MH, Washabau RJ, Kueppers F. Serum alpha 1–antitrypsin concentration in dogs with panniculitis. J. Am. Vet. Med. Assoc. [Internet]. 1996; 209(9):1582–1584. doi: https://doi.org/nw2c
Malik R, Love DN, Wigney DI, Martin P. Mycobacterial nodular granulomas affecting the subcutis and skin of dogs (canine leproid granuloma syndrome). Aust. Vet. J. [Internet]. 1998; 76(6):403–407. doi: https://doi.org/b95dzv
Behrend EN, Kooistra HS, Nelson R, Reusch CE, Scott–Moncrieff JC. Diagnosis of spontaneous canine hyperadrenocorticism: 2012 ACVIM Consensus Statement (Small Animal). J. Vet. Intern. Med. [Internet]. 2013; 27(6):1292–1304. doi: https://doi.org/f5htt3
Aikawa T, Yoshigae Y, Kanazono S. Epidural idiopathic sterile pyogranulomatous inflammation causing spinal cord compressive injury in five miniature Dachshunds. Vet. Surg. [Internet]. 2008; 37(6):594–601. doi: https://doi.org/dpbshq
De Decker S, Fenn J. Acute herniation of nondegenerate nucleus pulposus. Vet. Clin. North Am. Small Anim. Pract. [Internet]. 2018; 48(1):95–109. doi: https://doi.org/g8vnkk
Post K. Nodular panniculitis in a female toy poodle. Can. Vet. J. [Internet]. 1983 [cited 6 Aug. 2024]; 24(5):152–153. Available in: https://goo.su/1ca6ALI
Mansfield C. Acute pancreatitis in dogs: Advances in understanding, diagnostics, and treatment. Top. Companion Anim. Med. [Internet]. 2012; 27(3):123–132. doi: https://doi.org/f4f39s
Koch SN, Torres SMF, Plumb DC. Canine and feline dermatology drug handbook. Iowa (USA): John Wiley & Sons. 2013. Section 1, Systemic drugs; p 76–201.
Humbert P, Faivre B, Gibey R, Agache P. Use of anti–collagenase properties of doxycycline in the treatment of alpha 1–antitrypsin deficiency panniculitis. Acta Derm. Venereol. 1991; 71(3):189–194. PMID: 1678218

Copyright (c) 2024 Paula Bermúdez, Iovana Castellanos

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.