A field study on rational choice of medication: The use of Tilmicosin and Cefquinome in ovine footrot treatment

  • Ferit Yıldız Provincial Directorate of Agriculture and Forestry. Muş, Türkiye
  • Musa Gençcelep Van Yüzüncü Yıl University, Faculty of Veterinary, Department of Surgery.Van, Türkiye
Keywords: Antibiotic, food safety, footrot, residue, sheep

Abstract

In veterinary medicine, it is extremely important to use drugs that will not put human health at risk. In the treatment of animal diseases, the preference of drugs that accumulate in muscle tissue (meat) and are excreted from the body with milk because they create low treatment costs poses a public health and food safety risk. Veterinarians and animal breeders should pay attention to the use of drugs that do not leave residues in animal foods in the treatment of diseases of animals whose meat is eaten. With this study, it was aimed to reveal the healing time of Tilmicosin, which passed to milk and Cefquinome, which is not passed to milk are used in the treatment of footrot, especially in sheep raised for meat and milk, and what are the costs (medicine, labor, etc.) of both drugs to animal owners. The study was conducted on 80 sheep with footrot from sheep raised in Muş, Türkiye in 2020-21. As a result of field observations, anamnesis and clinical examinations, sheep with footrot were divided into two groups in equal numbers. One group was administered Cefquinome (1 mL·50 kg-1 im. every 24 hours –h–, 3 applications), while the other group was administered Tilmicosin (1 mL·30 kg-1 sc. 48 h later, 2 applications) and the animals were observed for 10 day (d). In the Cefquinome group, footrot could be treated at a rate of 90% on the 4th d and did not bring additional costs to the animal owners. It has been concluded that Cefquinome should be preferred in treatment in terms of animal health, food safety and public health due to its high treatment success, easy application in pasture conditions, and the availability of milk during treatment.

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References

Sağlıyan A, Güney C, Koparır M. [The Role of Copper and Zinc in the Etiology of Footrot of Sheep in Elazığ Region]. Vet. Cer. Derg. 2003; 9(1-2):11-16. Turkish.

Sertkaya H, Şındak N. [Incidence and treatment with two different drug combinations of sheep’ s footrot in Birecik district of Şanlıurfa and its villages]. Vet. Cer. Derg. 2004; 10(1-2):48-54. Turkish

Sulu K, Alkan F. [Footrot]. Bahri Dağdaş Hayvancılık Araştırma Dergisi. [Internet]. 2018 [cited 12 Feb 2024]; 7(1):18-32. Turkish. Available in: https://goo.su/W0UML

Yıldız F, Gençcelep M. [Comparative Studies on the Treatment and Incidence of Footrot in Sheep in Muş and its Region]. Van. Vet. J. [Internet]. 2021; 32(1):33-42. Turkish. https://doi.org/m84f

Green L, Kaler J, Wassink G, King E, Grogono-Thomas R. Impact of rapid treatment of sheep lame with footrot on welfare and economics and farmer attitudes to lameness in sheep. Anim. Welf. [Internet]. 2012; 21(S1):65-71. https://doi.org/f3zh2q

Lovatt F. Causes, control and costs of lameness in sheep. Vet. Irel. J. [Internet]. 2015 [cited 12 Jan 2024]; 5(4):189-192. Available in: https://goo.su/1ZVnow

Wassink GJ, King EM, Grogono-Thomas R, Brown JC, Moore LJ, Green LE. A within farm clinical trial to compare two treatments (parenteral antibacterials and hoof trimming) for sheep lame with footrot. Prev. Vet. Med. [Internet]. 2010; 96(1-2):93–103. https://doi.org/bx8z3v

Abbott KA, Lewis CJ. Current approaches to the management of ovine footrot. Vet. J. [Internet]. 2005; 169(1):28-41. doi: https://doi.org/bcsw9s

Grogono-Thomas R, Wilsmore AJ, Simon AJ, Izzard KA. The use of long-action oxytetracycline for the treatment of ovine footrot. Br. Vet. J. [Internet]. 1994; 150(6):561-568. https://doi.org/gf8f7j

Venning CM, Curtis MA, Egerton JR. Treatment of virulent footrot with lincomycin and spectinomycin. Aust. Vet. J. [Internet]. 1990; 67(7):258-260. https://doi.org/cmb32k

Winter A. Lameness in sheep. Small. Rum. Res. [Internet]. 2008; 76(1-2):149-153. https://doi.org/bbnk67

Alkan F. [Foot diseases in sheep and general approach]. In: 3rd Sheep Goat Health and Management Congress; 27-29 Apr 2017; Bursa (Türkiye): Farm Animal Medicine Association; 2017. p 23-32. Turkish.

Greber D, Bearth G, Lüchinger R, Schüpbach-Regula G, Steiner A. Elimination of virulent strains (aprV2) of Dichelobacter nodosus from feet of 28 Swiss sheep flocks: a proof of concept study. Vet. J. [Internet]. 2016; 216:25-32. https://doi.org/f87qw5

O’Neill J. Tackling drug-resistant ınfections globally: Final report and recommendations. The review on antimicrobial resistance [Internet]. London: Government of the United Kingdom; 2016 [cited 05 Feb 2024]; 84 p. Available in: https://goo.su/RTnHz

European Centre for Disease Prevention and Control. Guidelines for the prudent use of antimicrobials in veterinary medicine. Off. J. Eur. Union [Internet]. 2015 [cited 18 Feb 2024]; 26 p. Available in: https://goo.su/inGyzP

World Health Organization. Regional Office for Europe. Tackling antibiotic resistance from a food safety perspective in Europe [Internet]. Geneva (Switzerland); World Health Organization. Regional Office for Europe; 2011. 65 p. Available in: https://goo.su/gJLRVe

Bulut S. Elazığ ve yöresi koyun ve keçilerde görülen Piyeten’in etiyoloji, klinik seyir, epidemiyolojisi ile sağıtımlarının karşılaştırmalı araştırması [Comparative research on the etiology, clinical course, epidemiology and treatments of Piyeten seen in sheep and goats in Elazığ and its region]. [dissertation on the Internet]. Elazığ (Türkiye): Firat University; 1982 [cited 7 Sep 2023]. 110 p. Turkish. Available in: https://goo.su/6VpuIC

Klimek L, Aderhold C, Sperl A, Trautmann A. Allergic reactions to antibiotics – two sides of the same coin: clearly diagnose or reliably rule out. Allergo J. Int. [Internet]. 2017; 26:212-218. https://doi.org/m84g

Schenck FJ, Callery PS. Chromatographic methods of analysis of antibiotics in milk. J Chromatogr A. [Internet]. 1998; 812(1-2):99-109. https://doi.org/c6cj9f

Tadesse T, Tadesse T. Public health impacts of antibiotic residues in foods of animal origin: A review. Public Policy Adm. Res. [Internet]. 2017 [cited 21 Feb 2024]; 7(10):6-11. Available in: https://goo.su/3gelJ7

Samsar E, Akın F, Anteplioğlu H. Klinik Tanı Yöntemleri ve Genel Cerrahi [Clinical Diagnosis Methods and General Surgery]. 6th ed. Ankara (Türkiye): Tamer Matbaacılık Yayıncılık; 1996; 952 p. Turkish.

Sağlıyan A. [Clinical Evaluation of Sheep Foot Diseases Observed in Elazığ Region]. FÜ Sağlık Bilimleri Dergisi. [Internet]. 2003 [cited 12 Feb 2024]; 17(1):39-44. Turkish. Available in: https://goo.su/Ds2cQky

Liu N, Kaler J, Ferguson E, O’Kane H, Green L. Sheep farmers’ attitudes to farm inspections and the role of sanctions and rewards as motivation to reduce the prevalence of lameness. Anim. Welf. [Internet]. 2018; 27(1):67-79. https://doi.org/gc5px4

Forbes AB, Strobel H, Stamphoj I. Field studies on the elimination of footrot in sheep through whole flock treatments with gamithromycin. Vet. Rec. [Internet]. 2014; 174(6):283-284. https://doi.org/gf8f6t

Strobel H, Lauseker M, Forbes AB. Targeted antibiotic treatment of lame sheep with footrot using either oxytetracycline or gamithromycin. Vet. Rec. [Internet]. 2014; 174(2):46. https://doi.org/gbffmv

Whittington RJ. Observations on the indirect transmission of VFR in sheep yards and its spread in sheep on unimproved pasture. Aust. Vet. Journal. [Internet]. 1995; 72(4):132-134. https://doi.org/dzhntc

Casey RH, Martin PAJ. Effect of foot paring of sheep affected with footrot on response to zinc sulphate/sodium lauryl sulphate foot bathing treatment. Aust. Vet. Journal. [Internet]. 1988; 65(5):258-259. https://doi.org/dgwv4x

Gönül R, Or ME, Dodurka HT. [Treatment of foot foot disease in sheep with penicillin+streptomycin combination and/or copper sulphate foot bath under field conditions]. İ. Ü. Vet. Fak. Derg. 2001; 27(1):171-177. Turkish.

Bruere AN, West DM. The Sheep: Health, Disease and Production. Auckland (New Zealand): New Zealand Veterinary Association; 1993. Chapter 11, Foot diseases and lameness; p. 224-230.

Karslı B, Elma E. [The Evaluation of the Efficacy of Different Treatment Methods for Virulent Footrot in Sheep]. Türkiye Klinikleri J. Vet. Sci. [Internet]. 2015; 6(2):39-47. Turkish. https://doi.org/m85d

Kraft AF, Strobel H, Hilke J, Steiner A, Kuhnert P. The prevalence of Dichelobacter nodosus in clinically footrot-free sheep flocks: a comparative field study on elimination strategies. BMC Vet Res. [Internet]. 2020; 16(21). https://doi.org/m84h

Yarsan E. Hayvansal Gıdalarda Veteriner İlaç Kalıntıları. In: Uluslararası II. Helal ve Sağlıklı Gıda Kongresi; 07-10 Nov 2013; Konya, Turkey. [cited 08 Sep 2023]. Available in: https://goo.su/Ehhhhz

Groenevelt M, Grogono-Thomas R. What is the evidence base for blanket antibiotic therapy in the control of footrot in sheep? Livest. [Internet]. 2018; 23(Suppl. 5):20-23. https://doi.org/m84j

Zanolari P, Dürr S, Jores J, Steiner A, Kuhnert P. Ovine footrot: A review of current knowledge. Vet. J. [Internet]. 2021; 271:105647. https://doi.org/m84k

Van Boeckel TP, Glennon EE, Chen D, Gilbert M, Robinson TP, Grenfell BT, Levin SA, Bonhoeffer S, Laxminarayan R. Reducing antimicrobial use in food animals. Science. [Internet]. 2017; 357(6358):1350-1352. https://doi.org/ggqsht

Klein E, Van Boeckel TP, Martinez EM, Pant S, Gandra S, Levin SA, Goossens H, Laxminarayan R. Global increase and geographic convergence in antibiotic consumption between 2000 and 2015. Proc. Natl. Acad. Sci. USA. [Internet]. 2018; 115(15):E3463-E3470. https://doi.org/gc6x2n

Gülmez M. [Antimicrobial Resistance: A Global Problem]. Dicle Üniv. Vet. Fak. Derg. [Internet]. 2022 [cited 21 Jan 2024]; 15(1):53-58. Turkish. Available in: https://goo.su/42t9Ur

Yarsan E. Veteriner Hekimlikte Antibiyotikler (Pratik Bilgiler Rehberi) [Antibiotics in Veterinary Medicine (Practical Information Guide)]. Ankara (Türkiye): Güneş Tıp Kitapevleri; 2013. 280 p. Turkish.

Odabaşıoğlu F. Morkaraman, Akkaraman ve İvesi Koyunlarının Süt Verim Özelliklerinin Karşılaştırılması [Comparison of Milk Yield Characteristics of Morkaraman, Akkaraman and Awasi Sheep] [dissertation on the Internet]. Elazığ (Türkiye): Firat University; 1983 [cited 7 Sep 2023] 58 p. Turkish. Available in: https://goo.su/w20NXr

Published
2024-07-25
How to Cite
1.
Yıldız F, Gençcelep M. A field study on rational choice of medication: The use of Tilmicosin and Cefquinome in ovine footrot treatment. Rev. Cient. FCV-LUZ [Internet]. 2024Jul.25 [cited 2024Nov.20];34(2):6. Available from: https://produccioncientificaluz.org/index.php/cientifica/article/view/42491
Section
Veterinary Medicine