Microscopic evaluation and Descriptive study of Crystals and Uroliths encountered in the Urinary tract system of Cats and Dogs

• Eren Polat Firat University, Faculty of Veterinary Medicine, Department of Surgery, Elazig, Turkey
• Emre Kaya Firat University, Faculty of Veterinary Medicine, Department of Biochemistry, Elazig, Turkey
• Münir Mert Oral Nova Veterinary Clinic, Balikesir, Turkey https://orcid.org/0000-0001-8638-0099
• Nisanur Çelikdemir Firat University, Faculty of Veterinary Medicine, Department of Biochemistry, Elazig, Turkey

DOI: https://doi.org/10.52973/rcfcv-e32166

Keywords: Calcium oxalate, cat, dog, urolite, struvite

Abstract

In this study, the presence and types of urine crystals in cats and dogs with urolithiasis/crystaluria and the effects of some demographic factors (such as type, breed, age, sex, sterilization status) on them were evaluated. In the study, physical, chemical and sediment examinations of urine samples of 67 cats and dogs were performed. It was determined that 83.58% of the animals with crystals in their urine were male. It was determined that 63.64% of the female animals and 44.64% of the male animals with crystals detected in the urinary tract were sterilized. It was determined that urinary crystals were more common in cats between 1-3 years of age (AO) and in dogs older than 3 AO. It was determined that calcium oxalate crystal (64.41%) in cats and struvite crystal (50%) in dogs were the most common crystals. It was determined that urine crystals were found mostly in cross breeds in cats and dogs. It was determined that most of the cats and dogs with urine crystals were fed with home meals and non-branded foods. It was determined that urinary tract infections had an effect on the formation of urine crystals. As a result, it was concluded that it is important in terms of Veterinary Medicine that such studies should be routinely performed, especially in the United States of North America (such as the Minnesota Urolith Center), since urine crystals cause significant lower urinary system diseases.

References

AKÉ–CHIÑAS, M.A.; MENDOZA–LÓPEZ, C.I.; DEL ANGEL–CARAZA, J.; QUIJANO–HERNANDEZ, I.A.; RODRIGUEZ–ALARCON, C.A.; BARBOSA–MIRELES, M.A. Canine struvite urolithiasis: Epidemiological and clinical characteristics in Mexico. J. MVZ Cordoba. 27(1): e2338: 1–10. 2022.

ALBASAN, H.; OSBORNE, C.A.; LULICH, J.P.; LEKCHAROENSUK, C.; KOEHLER, L.A.; ULRICH, L.K.; SWANSON, L.L. Rate and frequency of recurrence of uroliths after an initial ammonium urate, calcium oxalate, or struvite urolith in cats. JAVMA. 235(12): 1450–1455. 2009.

ALBASAN, H.; OSBORNE, C.A.; LULICH, J.P.; SANCAK, A.A. Köpek ve kedilerde ürolitiazis. Türkiye Klinikleri J. Vet. Sci. 4(2): 39–52. 2013.

BARTGES, J.W.; OSBORNE, C.A.; LULICH, J.P.; KRUGER, J.M.; SANDERSON, S.L.; KOEHLER, L.A.; ULRICH, L.K. Canine urate urolithiasis. Etiopathogenesis, diagnosis, and management. Vet. Clin. North. Am. Small Anim. Pract. 29: 161–191. 1999.

DAUDON, M.; FROCHOT, V. Crystalluria. De Gruyter–Clin. Chem. Lab. Med. (CCLM). 53: 1479–1487. 2015.

GISSELMAN, K.; LANGSTON, C.; PALMA, D; Mc CUE, J. Calcium Oxalate Urolithiasis. Compend. Contin. Educat. Vet. 1: 496–502. 2009.

HESS, R.C.; KASS, P.H.; WARD, C.R. Association between hyperadrenocorticism and development of calcium–containing uroliths in dogs with urolithiasis. JAVMA. 212: 1889–1891. 1998.

HOUSTON, D.M.; MOORE, A.P.E. Canine and feline urolithiasis: Examination of over 50 000 urolith submissions to the Canadian Veterinary Urolith Centre from 1998 to 2008. Canad. Vet. J. 50: 1263–1268. 2009.

KATICA, M.; AHMED, N.H.; GRADAŠČEVIĆ, N.; SALKIĆ, A.; DERVIŠEVIĆ, E.A.A. contribution to the study of crystalluria: significance in the diagnosis of metabolic and renal diseases. J. Adv. Vet. Bio. Sci. Tech. 5(2): 81–89. 2020.

KIM, J.; SONG, R.; LEE, D.; LEE, H.; BAEK, D.; PARK, J.; PARK, C. Uncommon Case of Bladder Struvite Urolithiasis in a Two Month Old Puppy. J. Vet. Clin. 29(3): 268–270. 2012.

KOEHLER, L.A.; OSBORNE, C.A.; BUETTNER, M.T.; LULICH, J.P.; BEHNKE, R. Canine uroliths: frequently asked questions and their answers. Vet. Clin. Small Anim. 39: 161–181. 2008.

KOPECNY, L.; PALM, C.A.; SEGEV, G.; WESTROPP, J.L. Urolithiasis in dogs: evaluation of trends in urolith composition and risk factors (2006–2018). J. Vet. Inter. Med. 1: 1–10. 2021.

KUÇUK, O. Köpeklerde İdrar Taşları. Pratik Kedi ve Köpek Besleme–Beslenme Hastalıkları. 1st. Ed. Verda Publishing, Kayseri. Pp 325. 2020.

LANGSTON, C.; GISSELMAN, K.; PALMA, D.; Mc CUE, J. Diagnosis of ürolithiasis. Compend. Contin. Educat. Vet. 30(8): 447–454. 2008.

LOW, W.W.; UHL, J.M.; KASS, P.H.; RUBY, A.L.; WESTROPP, J.L. Evaluation of trends in urolith composition and characteristics of dogs with urolithiasis: 25,499 cases (1985–2006). JAVMA. 236(2): 193–200. 2010.

LULICH, J.P.; OSBORNE, C.A.; BARTGES, J.W.; LEKCHAROENSUK, C. Canine lower urinary tract disorders. In: Ettinger, SJ; Feldman, EC. (Eds.). Textbook of Veterinary Internal Medicine. Philadelphia: WB Saunders. 1747–1781 pp. 2000.

OKAFOR, C.C.; PEARL, D.L.; BLOIS, S.L.; LEFEBVRE, S.L.; YANG, M.; LUND, E.M.; DEWEY, C.E. Factors associated with hematuric struvite crystalluria in cats. J. Feline Med. Surg. 21(10): 922–930. 2018.

OSBORNE, C.A.; LULICH, J.P.; BARTGES, J.W. Canine and feline urolithiasis: Relationship of etiopathology genesis to treat and prevention. Canine struvite urolithiasis. (851–865). In: Osborne, CA; Finco, DR. (Eds.). Canine and Feline Nephrology and Urology. Baltimore: Williams & Wilkins. Pp 526. 1995.

OSBORNE, C.A.; LULICH, J.P.; POLZIN, D.J.; ALLEN, T.A.; KRUGER, J.M.; BARTGES, J.W.; KOEHLER, L.A.; ULRICH, L.K.; BIRD, K.A.; SWANSON, L.L. Medical dissolution and prevention of canine struvite urolithiasis. Twenty years of experience. Vet. Clin. North Am. Small Anim. Pract. 29(1): 73–111. 1999.

OSBORNE, C.A.; KRUGER, J.M.; LULICH, J.P.; POLZIN, D.J.; LEKCHAROENSUK, C. Feline lower urinary tract disorders. (1710–1747) In: Ettinger, SJ; Feldman, EC. (Eds.). Textbook of Veterinary Internal Medicine. Philadelphia: WB Saunders. Pp 366. 2000.

SANCAK, I.G.; OZGENCIL, F.E.; SANCAK, A.A. Fakülte kliniklerine gelen (2002–2003) kedi ve köpeklerde ürolitiazis olgularının klinik değerlendirilmesi. Ankara Univ. Vet. Fak. Derg. 56: 105–111. 2009.

STEVENSON, A.E.; ROBERTSON, W.G.; MARKWELL, P.J. Risk factor analysis and relative supersaturation as 19. tools for identifying calcium oxalate stone–forming dogs. J. Small Anim. Pract. 44: 491–496. 2003.

TİON, M.T.; DVORSKA, J.; SAGANUWAN, S.A. A review on urolithiasis in dogs and cats. Bulgarian J. Vet. Med. 18(1): 1–18. 2015.

TİRUNEH, D.; ABDİSA, T. Review on canine urolithiasis. Ame. Res. J. Vet. Med. 1(1): 1–7. 2017.

WATSON, J.M.; SHREWSBERRY, A.B.; TAGHECHIAN, S.; GOODMAN, M.; PATTARAS, J.G.; RITENOUR, C.W.; OGAN, K. Serum testosterone may be associated with calcium oxalate urolithogenesis. J.Endourol. 24(7): 1183–1187. 2010.