Comparison of the efficacy between natural honey and Manuka honey on Rabbit wounds

• Vinicio Samaniego-Rojas Universidad Católica de Cuenca, Posgrado. Cuenca, Azuay, Ecuador
• Nathalie Campos-Murillo Universidad Católica de Cuenca. Cuenca, Azuay, Ecuador

DOI: https://doi.org/10.52973/rcfcv-e32145

Keywords: Healing time, honey, wound healing

Abstract

Honey has been known for its anti-inflammatory and antibacterial properties since ancient times. Due to the high rate of emergence of antibiotic-resistant bacteria, alternative therapies, such as honey, are used to treat ulcers, burns and wounds. The objective of this research was to evaluate the efficacy of natural honey versus medical grade honey called Manuka in the treatment of wounds. A descriptive, observational and comparative study on the healing effects of honey was carried out with a universe of 24 rabbits in the veterinary clinic “San Fernandos” in the city of Loja, Ecuador; under anesthetic effects, a 3 x 3 centimeters guide wound was made in the dorsal region of the back, in the anterior third of the rabbit’s body, which was treated with natural honey and Manuka medical grade honey. Skin samples were obtained from both treatments at 5, 10 and 15 days post incision. The results obtained show that granular tissue formation and healing is faster in group B, since Manuka medical grade honey was used. The results show that granular tissue formation and healing is faster in group B, since Manuka honey was used in which it contributes to the regeneration of wounds, achieving and effective, fast and good quality healing, followed by group A which received the natural honey.

References

ACEVES-SÁNCHEZ, M.J.; FLORES-VALDEZ, M.A. Modelos Animales Para La Evaluación De Vacunas Contra Tuberculosis Estudios Preclínicos en Investigación Desarrollo e Investigación Biotecnológica (CIATEJ). Pp 109–121. 2016.

AHMED, S.; OTHMAN, N. Review of the Medicinal Effects of Tualang Honey and a Comparison with Manuka Honey. Malays J. Med. Sci. 20: 6–13. 2013.

ALLER, R.; RODRIGUEZ ,G.; RODRIGUEZ, F. Normas éticas para el cuidado y utilización de los animales de experimentación, Cirugía Española. 1: 10-13. 2000.

ASMA, B.; KARIM, A.; HMIDA, H. Effects of Topical Application of Clay and Honey on Cutaneous Wound Healing in Rabbits, Worlds Vet. J. 6(1): 15. 2014. https://doi.org/hzmn.

BARRETO-VILLANUEVA, A. The progress of statistics and its usefulness in development assessment. Pap. Poblac. 18 (73): 241–271. 2012.

BURLANDO, B.; CORNARA, L. Honey in dermatology and skin care. A review. J. Cosmet. Dermatol. 12: 306-313. 2013. https://doi.org/f5n97v.

CHUMACERO, J.N. Comparación de la miel de abeja y Violeta de Genciana en la cicatrización de heridas en cuyes Cavia porcellus Universidad Nacional Pedro Ruiz Gallo, Facultad de Medicina Veterinaria,Lambeyeque, Perú. Tesis de Grado. 52pp. 2017.

COOPER, R.A.; MOLAN,P.C.; HARDING,K.G. Antibacterial activity of honey against strains of Staphylococcus aureus from infected wounds. J. R. Soc. Med. 92 (6): 283–285. 1999. https://doi.org/hzmp.

GONZÁLEZ-GASCÓN, R.; DEL DEDO-TORRE, P. Actualización Sobre El Uso De Miel. Enfermeria Global. 4: 1–10. 2004.

GUTIÉRREZ, M.G.; RODRÍGUEZ-MALAVAER, A.; VIT, P. Miel de abejas Una fuente de antioxidantes Fuerza Farm. 1: 39–44. 2008.

HWISA, N.T.; KATAKAM, P.; CHANDU, B.R.; ABADI, E.G.; SHEFHA, E.M Comparative in vivo evaluation of three types of honey on topical wound healing activity in rabbits. J. Appl. Pharm. Sci. 3(8): 139–143. 2013.

JONES, R. Prologue: Honey and healing through the ages. J. ApiProduct. ApiMedical Sci. 1 (1): 2–5. 2009. https://doi.org/d579g9.

MARTINEZ,R.A. La Miel en el Tratamiento de Heridas. Universidad. Cantabria. España. Tesis de Grado. 1 (1): 16–21. 2014.

PATAQUIVA-AMARIS, J.A. Terapia No Farmacologica Para El Manejo De Heridas. Universidad Ciencias Aplicadas y Ambientales, Bogota, Colombia. 44 pp. 2016. En línea: https://bit.ly/3OapUO5. 01/01/2022.

PATRICIA, V. Por qué se estudia la actividad antibacteriana de las mieles. Iniciación a la Apiterapia. Universidad de Los Andes. (Bdigital.Ula.Ve). 1era. Ed. APIBA-CDCHT Universidad de Los Andes. Venezuela. 32 pp. 2006.

RODRÍGUEZ, I.L. Curación de heridas sépticas con miel de abejas Rev. Cuba Cir. 50(2): 187–196. 2011.

SALEM, N.; PEREZ, P.; HENNING, L. Comparative efficacy of manuka honey and povidone gel on healing of induced incisional wounds in rabbits. Pesquisa Agrop. Bras. 9(2):1385–1395. 2020. https://doi.org/hzmq.

SAMPERIO, G.; GARAY, C.; GUITRÓN, A.; VEGA, J. Modelo para la valoración cuantitativa de la cicatrización. Estudio piloto con miel de abeja. Ciruj. Gener. Artic. Orig 27: 114–119. 2015. En línea: https://bit.ly/3O584vM. 04/01/2022.

SCHENCKE, C.; DEL SOL, M.; SANDOVAL, C.; VÁSQUEZ, B. El rol de la Miel en los Procesos Morfofisiológicos de Reparación de Heridas. Int. J. Morphol. 34(1): 385-395. 2016.

ULLOA, A. ; MONDRAGÓN, C.; ROGELIO, Q. La miel de abeja y su importancia. Fuente. 2(4): 11–18. 2010.

VELASQUEZ, M. Valoración clínica del tiempo y proceso de cicatrización de heridas experimentales tras la aplicación tópica miel de abejas y propóleos en cobayos. Universidad Central del Ecuador. Facultad de Medicina Veterinaria y Zootecnia. Quito, Ecuador. Tesis de Grado. 72pp. 2018.