Resveratrol reduces the spontaneous contractions of rabbit duodenum
El resveratrol reduce las contracciones espontaneas del duodeno de conejo
Keywords:
Resveratrol, duodenum, spontaneous contractions, Ca2 channels, rabbit
Abstract
Resveratrol, a natural polyphenol, is known for its antioxidant, anti-inflammatory, analgesic, antiviral, cardioprotective, neuroprotective and antiageing action. The aim of this study was to investigate the effect of resveratrol on the spontaneous contractions of rabbit duodenum (RD). Isolated segments of RD were suspended in an organ bath. Resveratrol (1 and 10 μM) reduced the amplitude but not the frequency of the spontaneous contractions in the longitudinal smooth muscle of RD. Bay K8644 (L-type Ca2+ channel activator) antagonized the inhibition of amplitude of spontaneous contractions induced by resveratrol. Apamin, charybdotoxin, glibenclamide and tetraethylamoniun did not modify the effect of resveratrol on duodenal muscle. It was conclude that the decrease of the spontaneous contractions induced by resveratrol would be mediated by Ca2+ channels.
Downloads
Download data is not yet available.
References
CATALGOL, B.; BATIREL, S.; TAGA, Y.; OZER, N.K. Resveratrol: French paradox revisited. Front. Pharmacol. 3: 141. 2012.
DOBRZYNSKA, M.M. Resveratrol as promising natural radioprotector. A review. Rocz Panstw Zakl Hig. 64(4): 255- 62. 2013.
FAGUNDES, D.S.; GONZALO, S.; ARRUEBO, M.P.; PLAZA, M.A.; MURILLO, M.D. Melatonin and Trolox ameliorate duodenal LPS-induced disturbances and oxidative stress. Dig. Liver Dis. 42(1): 40-4. 2010.
FAGUNDES, D.S.; GONZALO, S.; GRASA, L.; CASTRO, M.; ARRUEBO, M.P.; PLAZA, M.A.; MURILLO, M.D. Trolox reduces the effect of ethanol on acetylcholine-induced contractions and oxidative stress in the isolated rabbit duode- num. Rev. Esp. Enferm. Dig. 103(8): 396-401. 2011.
FAGUNDES, D.S.; GRASA, L.; GONZALO, S.; MARTINEZ DE S,F.; ARRUEBO, M.P.; PLAZA, M.A.; MURILLO, M.D. Mechanism of action of Trolox on duodenal contractility. J. Physiol. Pharmacol. 64(6): 705-10. 2013.
FREMONT, L. Biological effects of resveratrol. Life Sci. 66(8): 663-73. 2000.
GOJKOVIC-BUKARICA, L.; NOVAKOVIC, A.; KANJUH, V.; BUMBASIREVIC, M.; LESIC, A.; HEINLE, H. A role of ion channels in the endothelium-independent relaxation of rat mesenteric artery induced by resveratrol. J. Pharmacol. Sci. 108(1): 124-30. 2008.
GRASA, L.; REBOLLAR, E.; ARRUEBO, M.P.; PLAZA, M.A.; MURILLO, M.D. The role of Ca2+ in the contractility of rabbit small intestine in vitro. J. Physiol. Pharmacol. 55(3): 639-50. 2004.
HANSEN, M.B. Neurohumoral control of gastrointestinal motility. Physiol. Res. 52(1): p. 1-30. 2003.
LAMARCA, V.; GRASA, L.; FAGUNDES, D.S.; ARRUEBO, M.P.; PLAZA, M.A.; MURILLO, M.D. K+ channels involved in contractility of rabbit small intestine. J. Physiol. Biochem. 62(4): 227-36. 2006.
NOVAKOVIC, R.; ILIC, B.; BELESLIN-COKIC, B.; RADU- NOVIC, N.; HEINLE, H.; SCEPANOVIC, R.; GOJKOVIC-BUKARICA, L. The effect of resveratrol on contractility of non-pregnant rat uterus: the contribution of K(+) channels. J. Physiol. Pharmacol. 64(6): 795-805. 2013.
SANTOS-FAGUNDES, D.; GRASA, L.; GONZALO, S.; VA- LERO, M.S.; CASTRO, M.; ARRUEBO, M.P.; PLAZA, M.A.; MURILLO, M.D. Different mechanisms of actions of genistein, quercetin on spontaneous contractions of rabbit duodenum. Rev. Esp. Enferm. Dig. 107(7): 413-6. 2015.
THAZHATH, S.S.; WU, T.; BOUND, M.J.; CHECKLIN, H.L.; STANDFIELD, S.; JONES, K.L.; HOROWITZ, M.; RAYNER, C.K. Administration of resveratrol for 5 wk has no effect on glucagon-like peptide 1 secretion, gastric emptying, or glycemic control in type 2 diabetes: a randomized controlled trial. Am. J. Clin. Nutr. 103(1): 66-70. 2016.
TSAI, C.C.; TEY, S.L.; LEE, M.C.; LIU, C.W.; SU, Y.T.; HUANG, S.C. Mechanism of resveratrol-induced relaxation of the guinea pig fundus. Phytomed. 43: 55-59- 2018
TSUDA, Y.; NAKAHARA, T.; MORI, A.; SAKAMOTO, K.; IS-HII, K. Resveratrol prevents bradykinin-induced contraction of rat urinary bladders by decreasing prostaglandin production and calcium influx. Eur. J. Pharmacol. 666(1-3): 189- 95. 2011.
WANG, L.D.; QIU, X.Q.; TIAN, Z.F.; ZHANG, Y.F.; LI, H.F. Inhibitory effects of genistein and resveratrol on guinea pig gallbladder contractility in vitro. World J. Gastroenterol. 14(31): 4955-60. 2008.
ZHANG, L.X.; LI, H.F.; WANG, L.D.; JIN, S.; DOU, X.C.; TIAN, Z.F.; MA, Q. Resveratrol and genistein inhibition of rat isolated gastrointestinal contractions and related mecha- nisms. World J. Gastroenterol. 20(41): 15335-42. 2014.
DOBRZYNSKA, M.M. Resveratrol as promising natural radioprotector. A review. Rocz Panstw Zakl Hig. 64(4): 255- 62. 2013.
FAGUNDES, D.S.; GONZALO, S.; ARRUEBO, M.P.; PLAZA, M.A.; MURILLO, M.D. Melatonin and Trolox ameliorate duodenal LPS-induced disturbances and oxidative stress. Dig. Liver Dis. 42(1): 40-4. 2010.
FAGUNDES, D.S.; GONZALO, S.; GRASA, L.; CASTRO, M.; ARRUEBO, M.P.; PLAZA, M.A.; MURILLO, M.D. Trolox reduces the effect of ethanol on acetylcholine-induced contractions and oxidative stress in the isolated rabbit duode- num. Rev. Esp. Enferm. Dig. 103(8): 396-401. 2011.
FAGUNDES, D.S.; GRASA, L.; GONZALO, S.; MARTINEZ DE S,F.; ARRUEBO, M.P.; PLAZA, M.A.; MURILLO, M.D. Mechanism of action of Trolox on duodenal contractility. J. Physiol. Pharmacol. 64(6): 705-10. 2013.
FREMONT, L. Biological effects of resveratrol. Life Sci. 66(8): 663-73. 2000.
GOJKOVIC-BUKARICA, L.; NOVAKOVIC, A.; KANJUH, V.; BUMBASIREVIC, M.; LESIC, A.; HEINLE, H. A role of ion channels in the endothelium-independent relaxation of rat mesenteric artery induced by resveratrol. J. Pharmacol. Sci. 108(1): 124-30. 2008.
GRASA, L.; REBOLLAR, E.; ARRUEBO, M.P.; PLAZA, M.A.; MURILLO, M.D. The role of Ca2+ in the contractility of rabbit small intestine in vitro. J. Physiol. Pharmacol. 55(3): 639-50. 2004.
HANSEN, M.B. Neurohumoral control of gastrointestinal motility. Physiol. Res. 52(1): p. 1-30. 2003.
LAMARCA, V.; GRASA, L.; FAGUNDES, D.S.; ARRUEBO, M.P.; PLAZA, M.A.; MURILLO, M.D. K+ channels involved in contractility of rabbit small intestine. J. Physiol. Biochem. 62(4): 227-36. 2006.
NOVAKOVIC, R.; ILIC, B.; BELESLIN-COKIC, B.; RADU- NOVIC, N.; HEINLE, H.; SCEPANOVIC, R.; GOJKOVIC-BUKARICA, L. The effect of resveratrol on contractility of non-pregnant rat uterus: the contribution of K(+) channels. J. Physiol. Pharmacol. 64(6): 795-805. 2013.
SANTOS-FAGUNDES, D.; GRASA, L.; GONZALO, S.; VA- LERO, M.S.; CASTRO, M.; ARRUEBO, M.P.; PLAZA, M.A.; MURILLO, M.D. Different mechanisms of actions of genistein, quercetin on spontaneous contractions of rabbit duodenum. Rev. Esp. Enferm. Dig. 107(7): 413-6. 2015.
THAZHATH, S.S.; WU, T.; BOUND, M.J.; CHECKLIN, H.L.; STANDFIELD, S.; JONES, K.L.; HOROWITZ, M.; RAYNER, C.K. Administration of resveratrol for 5 wk has no effect on glucagon-like peptide 1 secretion, gastric emptying, or glycemic control in type 2 diabetes: a randomized controlled trial. Am. J. Clin. Nutr. 103(1): 66-70. 2016.
TSAI, C.C.; TEY, S.L.; LEE, M.C.; LIU, C.W.; SU, Y.T.; HUANG, S.C. Mechanism of resveratrol-induced relaxation of the guinea pig fundus. Phytomed. 43: 55-59- 2018
TSUDA, Y.; NAKAHARA, T.; MORI, A.; SAKAMOTO, K.; IS-HII, K. Resveratrol prevents bradykinin-induced contraction of rat urinary bladders by decreasing prostaglandin production and calcium influx. Eur. J. Pharmacol. 666(1-3): 189- 95. 2011.
WANG, L.D.; QIU, X.Q.; TIAN, Z.F.; ZHANG, Y.F.; LI, H.F. Inhibitory effects of genistein and resveratrol on guinea pig gallbladder contractility in vitro. World J. Gastroenterol. 14(31): 4955-60. 2008.
ZHANG, L.X.; LI, H.F.; WANG, L.D.; JIN, S.; DOU, X.C.; TIAN, Z.F.; MA, Q. Resveratrol and genistein inhibition of rat isolated gastrointestinal contractions and related mecha- nisms. World J. Gastroenterol. 20(41): 15335-42. 2014.
Published
2019-08-18
How to Cite
1.
Santos-Fagundes D, Gonzalo S, Grasa L, Murillo MD. Resveratrol reduces the spontaneous contractions of rabbit duodenum: El resveratrol reduce las contracciones espontaneas del duodeno de conejo. Rev. Cient. FCV-LUZ [Internet]. 2019Aug.18 [cited 2024Nov.24];29(4):260-4. Available from: https://produccioncientificaluz.org/index.php/cientifica/article/view/36548
Section
Veterinary Medicine
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
