Microbiota intestinal, fibrosis quística y eje intestino pulmón intestinal

Intestinal microbiota, cystic fibrosis and intestinal-lung axis

• Yalitza Josefina Moreno Hospital de Especialidades Pediátricas. Maracaibo, Venezuela. http://orcid.org/0009-0006-4978-192X

DOI: https://doi.org/10.5281/zenodo.11265199

Keywords: Cystic fibrosis, CFTR (Cystic fibrosis transmembrane conductance regulatory protein)

Abstract

Cystic fibrosis (CF) is a hereditary, autosomal recessive disease with multisystem involvement, caused by mutations in the gene that encodes the Cystic Fibrosis Transmembrane Conductance Regulatory Protein (CFTR) located on chromosome 7. It is a hereditary disease. More common in Caucasians, these mutations cause dysfunction or absence of CFTR, triggering abnormalities in chloride secretion, sodium reabsorption and water transport, affecting multiple organs and systems, given the expression of this protein in all epithelial cells. Inflammation in Cystic Fibrosis is defined as chronic and low grade, in which immune system cells participate, generating proinflammatory cytokines, it also increases the production of reactive oxygen species that generate greater oxidative stress and contributes to maintaining intestinal  inflammation and systemic. The intestinal microbiota may have a bidirectional link and a significant clinical association with health or disease, intestinal dysbiosis has been reported since the sixth week of life, is related to the alteration of CFTR and inflammation, is characterized by a decrease in relative bacterial abundance and diversity is associated with a decrease in lung function through the intestine-lung axis, an intestinal decrease in Bacteroides and Bifidubacterium and an increase in Staphylococcus, Enterobacteriaceae and Veillonella have been reported, the interconnection between the gastrointestinal system and the Respiratory disease is evidenced by the presence of bacterial genera such as Enterococcus and Escherichia coli that initially colonize the intestine and then the lung.

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