Determinación de los niveles de Zonulina sérica y fecal en la gastroenteritis canina causada por algunas enfermedades infecciosas y no infecciosas

• Deniz Şardağ Aydın Adnan Menderes University, Veterinary Faculty, Department of Internal Medicine, 09900, Aydın, Türkiye. https://orcid.org/0009-0005-9046-0733
• Kerem Ural Aydın Adnan Menderes University, Veterinary Faculty, Department of Internal Medicine, 09900, Aydın, Türkiye. https://orcid.org/0000-0003-1867-7143
• Deniz Alic-Ural Aydın Adnan Menderes University, Sultanhisar Vocational School, Department of Plant and Animal Production, 9740, Aydın, Türkiye. https://orcid.org/0000-0002-2659-3495
• Serdar Pasa Aydın Adnan Menderes University, Veterinary Faculty, Department of Internal Medicine, 09900, Aydın, Türkiye. https://orcid.org/0000-0003-4957-9263
• Hasan Erdogan Aydın Adnan Menderes University, Veterinary Faculty, Department of Internal Medicine, 09900, Aydın, Türkiye. https://orcid.org/0000-0001-5141-5108
• Songul Erdogan Aydın Adnan Menderes University, Veterinary Faculty, Department of Internal Medicine, 09900, Aydın, Türkiye. https://orcid.org/0000-0002-7833-5519

DOI: https://doi.org/10.52973/rcfcv-e363949

Palabras clave: Permeabilidad intestinal, marcador intestinal, diarrea en perros, marcadores no invasivos, síndrome del intestino permeable

Resumen

Este estudio tuvo como objetivo determinar simultáneamente los niveles de zonulina en heces y sangre como un verdadero biomarcador para la detección y la gravedad del intestino permeable, que puede desarrollarse debido a diarrea infecciosa o no infecciosa de diversas causas etiológicas en perros. Cincuenta y cuatro perros, 45 con gastroenteritis y 9 perros sanos, fueron llevados a la clínica con antecedentes de diarrea de al menos un día de duración y fueron clasificados según su etiología según análisis clínicos de laboratorio. Los niveles de zonulina se determinaron a partir de muestras de sangre y heces mediante el ensayo de inmunoadsorción ligado a enzima. Se encontraron diferencias significativas entre el grupo sano y todos los grupos en cuanto a zonulina sérica y fecal. Los niveles de zonulina fecal en el grupo enfermo difirieron significativamente entre el grupo con coronavirus y los grupos con giardia y parvovirus, mientras que los niveles séricos de zonulina también difirieron significativamente en el grupo con moquillo. Los hallazgos sugieren que los niveles de zonulina fecal y sérica pueden utilizarse como un biomarcador no invasivo de disfunción de la barrera hematoencefálica en perros con gastroenteritis.

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