Evaluación histológica de los efectos de la administración sistémica de ranelato de estroncio sobre la curación ósea en fracturas de tibia de rata

• Mehmet Gul Nevsehir Hacı Bektas Veli University, Faculty of Dentistry, Department of Periodontology, Nevsehir, Türkiye. ²Firat University, Faculty of Veterinary Medicine, Department of Surgery, Elazig, Türkiye. https://orcid.org/0000-0002-5721-8778
• Murat Tanrisever Firat University, Faculty of Veterinary Medicine, Department of Surgery, Elazig, Türkiye. https://orcid.org/0000-0003-3815-8543
• Muge Bereket Altintas Firat University, Faculty of Dentistry, Department of Peridontology, Elazig, Türkiye https://orcid.org/0009-0001-4810-6678
• Ozmen Istekt Mus Alparslan University, Faculty of Health Sciences, Department of Nursing, Mus, Türkiye. https://orcid.org/0000-0002-7536-7064
• Umit Koray Can Turkish Jockey Club, Elazig Racecourse Horse Hospital, Elazig, Türkiye. https://orcid.org/0000-0002-3272-6311
• Erhan Cahit Ozcan Firat University, Faculty of Medicine, Department of Plastic, Reconstructive and Aesthetic Surgery, Elazig, Türkiye. https://orcid.org/0000-0001-6513-0226
• Tugce Donmezer Tekirdag Namik Kemal University, Faculty of Dentistry, Department of Periodontology, Tekirdag, Türkiye. https://orcid.org/0000-0003-3732-1193
• Serkan Dundar Firat University, Faculty of Dentistry, Department of Peridontology, Elazig, Türkiye. https://orcid.org/0000-0003-3944-1957
• Burak Karabulut Firat University, Faculty of Veterinary Medicine, Department of Pathology, Elazig, Türkiye. https://orcid.org/0000-0002-4907-6159

DOI: https://doi.org/10.52973/rcfcv-e362859

Palabras clave: Ranelato de estroncio, fractura de tibia, consolidación ósea, formación de hueso nuevo, rata

Resumen

Este estudio tuvo como objetivo investigar los efectos del ranelato de estroncio, un agente conocido similar a los bisfosfonatos con efectos sobre el tejido óseo, en la cicatrización de fracturas y defectos óseos mediante métodos histológicos. Para ello, se realizó un estudio de fracturas con 28 ratas, cada una compuesta por controles sanos (n = 7), controles con fractura y grupos de tratamiento, que recibieron una dosis de estroncio de 450 mg/kg tres veces por semana y una dosis de 900 mg/kg tres veces por semana. Tras un periodo de cicatrización de seis semanas, se realizó un análisis histológico de las tibias para evaluar la formación de hueso nuevo. Los datos se analizaron mediante las pruebas de Kruskal-Wallis y U de Mann-Whitney. La formación de hueso nuevo fue significativamente  menor  en  los  grupos con fractura en comparación con los controles sanos (P < 0,001). Se observó un aumento en la proporción de formación de hueso nuevo en los grupos tratados con ranelato de estroncio en comparación con los controles con fractura (P < 0,05). La formación de hueso nuevo fue significativamente mayor en el grupo tratado con dosis altas de ranelato de estroncio en comparación con el grupo tratado con dosis bajas (P < 0,05). Al evaluar conjuntamente los análisis histológicos y numéricos, se concluyó que la administración sistémica de ranelato de estroncio aceleró significativamente los procesos de formación y maduración de hueso nuevo durante la consolidación de la fractura, dependiendo de la dosis utilizada (450 y 900 mg/kg).

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