Explorando el perfil químico, antioxidante, antiinflamatorio in vivo y propiedades gastroprotectoras de la sandía (Citrullus lanatus thunb.) en ratas

• Amel Bouaziz University Ferhat Abbas Setif 1, Faculty of Nature and Life Sciences, Laboratory of Phytotherapy Applied to Chronic Diseases. Setif, Algeria
• Saliha Djidel University Ferhat Abbas Setif 1, Faculty of Nature and Life Sciences, Laboratory of Phytotherapy Applied to Chronic Diseases. Setif, Algeria
• Assia Bentahar University Ferhat Abbas Setif 1, Faculty of Nature and Life Sciences, Laboratory of Phytotherapy Applied to Chronic Diseases. Setif, Algeria
• Nihed Barghout University Ferhat Abbas Setif 1, Faculty of Nature and Life Sciences, Laboratory of Phytotherapy Applied to Chronic Diseases. Setif, Algeria
• Seddik Khennouf University Ferhat Abbas Setif 1, Faculty of Nature and Life Sciences, Laboratory of Phytotherapy Applied to Chronic Diseases. Setif, Algeria
• Saliha Dahamna University Ferhat Abbas Setif 1, Faculty of Nature and Life Sciences, Laboratory of Phytotherapy Applied to Chronic Diseases. Setif, Algeria

DOI: https://doi.org/10.52973/rcfcv-e34508

Palabras clave: Citrullus lanatus thunb, flavonoides, inflamación, estrés oxidativo, polifenoles, taninos, úlcera

Resumen

Citrullus lanatus thunb. (sandía), perteneciente a la familia Curcubitaceae, es el cultivo más importante a nivel mundial. El presente trabajo tiene como objetivo estimar el contenido polifenólico, las propiedades antiinflamatorias y antiulcerosas, además de la actividad antioxidante del extracto etanólico de pulpa de sandía. El extracto etanólico de sandía contiene metabolitos secundarios, polifenoles, flavonoides y taninos. Se utilizaron pruebas de poder reductor y ensayo de eliminación Ácido 2,2-azino-bis(3-etil benzotiazolina-6-sulfónico) (ABTS) para medir la actividad antioxidante. En las dos pruebas examinadas, el extracto etanólico de sandía demostró un potente potencial antioxidante. El pretratamiento de ratas con extracto de sandía a las dosis de 200 y 600 mg·kg^-1 demostró un efecto antiinflamatorio significativo y disminuyó el edema de la pata inducido por carragenina, con porcentajes de inhibición de 57,24 ± 3,18 y 69,00 ± 2,80 %, respectivamente. Sin embargo, las dosis de 50, 200 y 600 mg·kg^-1 de extracto de sandía pretratado a ratas redujeron la lesión de la mucosa gástrica en la úlcera gástrica aguda inducida por etanol con porcentajes de protección de 75,01 ± 0,77, 92,38 ± 2,98 y 95,01 ± 0,81 % en comparación con omeprazol (95,92 %). Este estudio reveló que el consumo de sandía podría ser un prometedor agente antiinflamatorio y gastroprotector.

Citas

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