Efecto protector del tirosol sobre la inflamación ovárica y el estrés oxidativo inducidos por cisplatino en ratas

  • İshak Gökçek Hatay Mustafa Kemal University, Faculty of Veterinary Medicine, Department of Veterinary Physiology. Hatay, Türkiye
  • Ahmet Gözer Hatay Mustafa Kemal University, Faculty of Veterinary Medicine, Department of Veterinary Obstetrics and Gynaecology. Hatay, Türkiye
  • Tuncer Kutlu Hatay Mustafa Kemal University, Faculty of Veterinary Medicine, Department of Veterinary Pathology. Hatay, Türkiye
  • Mehmet Güvenç Hatay Mustafa Kemal University, Faculty of Veterinary Medicine, Department of Veterinary Pathology. Hatay, Türkiye
  • Leyla Aydın Ankara Yıldırım Beyazıt University, Faculty of Medicine, Department of Physiology. Ankara, Türkiye
  • Gökhan Uyanık Erciyes University, Faculty of Veterinary Medicine, Department of Obstetrics and Gynaecology. Kayseri, Türkiye
Palabras clave: Ovario, cisplatino, tirosol, efecto protector, rata

Resumen

El cáncer de ovario es un tipo de cáncer muy extendido entre los cánceres ginecológicos y tiene una tasa de mortalidad muy alta. Por este motivo, continúa la búsqueda de nuevos tratamientos. El Tirosol es un compuesto fenólico con actividad antioxidante y antiinflamatoria. En el estudio, investigamos el efecto del tirosol sobre el estrés oxidativo y los parámetros inflamatorios en la inflamación ovárica y el estrés oxidativo inducidos por cisplatino en ratas. Para ello, veinticuatro ratas albinas Wistar se dividieron en cuatro grupos: control, Cisplatino, Tirosol y Cisplatino+Ttirosol. El Cisplatino se administró por vía intraperitoneal a 6 mg·kg-1 dos veces, una vez por semana. Se administró Tirosol (20 mg·kg-1) diariamente mediante sonda oral durante catorce d. Se midieron el estrés oxidativo y los biomarcadores inflamatorios en el tejido ovárico. La administración de Cisplatino aumentó los niveles de Malondialdehído (MDA), factor de necrosis tumoral alfa (TNF–α), interleucina 6 (IL–6) e interleucina 1 beta (IL–1β) en los ovarios, mientras que, el glutatión (GSH), la glutatión peroxidasa (GSH–Px), y los niveles de catalasa disminuyeron. Se demostró que la administración de tirosol disminuye los parámetros de estrés oxidativo y las citocinas inflamatorias. En conclusión, podemos decir que la actividad protectora del tirosol contra la inflamación ovárica y el estrés oxidativo inducidos por cisplatino se realiza a través de mecanismos antioxidantes y antiinflamatorios.

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Publicado
2024-09-19
Cómo citar
1.
Gökçek İshak, Gözer A, Kutlu T, Güvenç M, Aydın L, Uyanık G. Efecto protector del tirosol sobre la inflamación ovárica y el estrés oxidativo inducidos por cisplatino en ratas. Rev. Cient. FCV-LUZ [Internet]. 19 de septiembre de 2024 [citado 10 de octubre de 2024];34(3):6. Disponible en: https://produccioncientificaluz.org/index.php/cientifica/article/view/42756
Sección
Medicina Veterinaria