Efecto de la administración exógena de Melatonina sobre la Espermatogénesis en un modelo de rata con estrés crónico impredecible

• İshak Gökçek Hatay Mustafa Kemal University, Faculty of Veterinary Science, Department of Physiology. Hatay, Turkey https://orcid.org/
• Leyla Aydın Ankara Yıldırım Beyazıt University, Faculty of Medicine, Department of Physiology. Ankara, Turkey
• Mustafa Cellat Hatay Mustafa Kemal University, Faculty of Veterinary Science, Department of Physiology. Hatay, Turkey
• İlker Yavaş Hatay Mustafa Kemal University, Faculty of Veterinary Medicine, Department of Reproduction and Artificial Insemination. Hatay, Turkey
• Tuncer Kutlu Hatay Mustafa Kemal University, Faculty of Veterinary Medicine, Department of Pathology. Hatay, Turkey

DOI: https://doi.org/10.52973/rcfcv-e33288

Palabras clave: Estrés crónico, espermatogénesis, melatonina, antioxidante, citoquinas antiinflamatorias

Resumen

Este estudio investigó los efectos hormonales, inflamatorios, oxidantes–antioxidantes e histopatológicos de la administración exógena de melatonina sobre la espermatogénesis en el modelo de estrés crónico impredecible (CUSM) de ratas. En el presente estudio, el estrés provocó una disminución de los niveles de hormona foliculoestimulante (FSH), hormona luteinizante (LH), testosterona, melatonina, glutatión (GSH), glutatión peroxidasa (GSH–Px), catalasa, interleucina 10 (IL–10) y motilidad, y un aumento de la corticosterona, factor nuclear kappa beta (NF–kB), factor de necrosis tumoral alfa (TNF–α), interleucina 1 beta (IL–1β), interleucina 6 (IL–6), espermatozoides anormales, relación espermatozoides muertos/espermatozoides vivos y la melatonina exógena redujeron las citocinas inflamatorias y el estrés oxidativo y mejoraron los parámetros espermatológicos (P<0,05). La melatonina también corrigió parcialmente los cambios inducidos por el estrés en la morfología testicular. Como resultado, el uso de melatonina en ratas con CUSM puede ser eficaz para mejorar los parámetros espermatológicos a través de mecanismos antiinflamatorios y antioxidantes.

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