COVID-19: The new pandemic with many lessons and new challenges. Narrative Review
Abstract
The new coronavirus (2019-nCoV, SARS-CoV-2 or COVID-19), which so far has affected more than 180 countries on almost every continent, was declared a pandemic by the World Health Organization. its global reach and to date, has exceeded one million infected cases, of which 5.54% have been fatal. The emergence of this disease has been explained by the presence of an unknown human coronavirus with increased virulence factors. The exponentially increasing number of cases in the world reflects in part the rapid transmission of COVID-19, which translates into a severe test for the health systems of the most affected countries. The challenges that this pandemic has represented, many have been based on the lessons learned from the SARS pandemic in 2003 and given the genomic similarity of this new strain of coronavirus, it has been designated as SARS-CoV-2. However, the like, there are many questions still to be answered, especially with regard to transmission mechanisms. Having detailed and accurate data will make it possible to understand and monitor the scope of this pandemic and strengthen prevention and response efforts, since the treatments are so far experimental and the vaccine may be available in the medium or long term.References
Center for Systems Science and Engineering. COVID-19 Map-Johns Hopkins Coronavirus Resource Center [Internet]. 2020 [citado 6 de abril de 2020]. Disponible en: https://coronavirus.jhu.edu/map.html
Dong E, Du H, Gardner L. An interactive web-based dashboard to track COVID-19 in real time. Lancet Infect Dis [Internet]. 2020 [Publicación en avance]. Disponible en: https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(20)30120-1/fulltext DOI: 10.1016/S1473-3099(20)30120-1 PMID 32087114 Google Académico
Chan PKS. Outbreak of Avian Influenza A(H5N1) Virus Infection in Hong Kong in 1997. Clin Infect Dis [Internet]. 2002;34(Supplement_2):S58-64. Disponible en: https://doi.org/10.1086/338820 DOI: 10.1086/338820 PMID 11938498 Google Académico
Guan Y, Zheng BJ, He YQ, Liu XL, Zhuang ZX, Cheung CL, et al. Isolation and Characterization of Viruses Related to the SARS Coronavirus from Animals in Southern China. Science [Internet]. 10 de octubre de 2003;302(5643):276-278. Disponible en: http://science.sciencemag.org/content/302/5643/276.abstract DOI: 10.1126/science.1087139 PMID 12958366 Google Académico
Yu X-J, Liang M-F, Zhang S-Y, Liu Y, Li J-D, Sun Y-L, et al. Fever with Thrombocytopenia Associated with a Novel Bunyavirus in China. N Engl J Med [Internet]. 16 de marzo de 2011;364(16):1523-32. Disponible en: https://doi.org/10.1056/NEJMoa1010095 DOI: 10.1056/NEJMoa1010095 PMID 21410387 PMCID PMC3113718 Google Académico
Chafekar A, Fielding BC. MERS-CoV: Understanding the Latest Human Coronavirus Threat. Viruses [Internet]. Febrero de 2018;10(2). Disponible en: https://www.mdpi.com/1999-4915/10/2/93 DOI: 10.3390/v10020093 PMID 29495250 PMCID PMC5850400 Google Académico
Lu H, Stratton CW, Tang Y-W. Outbreak of pneumonia of unknown etiology in Wuhan, China: The mystery and the miracle. J Med Virol [Internet]. abril de 2020;92(4):401-2. Disponible en: https://onlinelibrary.wiley.com/doi/full/10.1002/jmv.25678 DOI: 10.1002/jmv.25678 PMID 31950516 Google Académico
Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet [Internet]. 15 de febrero de 2020;395(10223):497-506. Disponible en: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30183-5/fulltext DOI: 10.1016/S0140-6736(20)30183-5 PMID 31986264 Google Académico
World Health Organization. Clinical management of severe acute respiratory infection (SARI) when COVID-19 disease is suspected [Internet]. WHO. 2020 [citado 30 de marzo de 2020]. Disponible en: https://www.who.int/publications-detail/clinical-management-of-severe-acute-respiratory-infection-when-novel-coronavirus-(ncov)-infection-is-suspected
Tyrrell DAJ, Bynoe ML. Cultivation of viruses from a high proportion of patients with colds. Lancet [Internet]. 8 de enero de 1966;287(7428):76-7. Disponible en: https://doi.org/10.1016/S0140-6736(66)92364-6 DOI: 10.1016/S0140-6736(66)92364-6 PMID 4158999 Google Académico
Cui J, Li F, Shi Z-L. Origin and evolution of pathogenic coronaviruses. Nat Rev Microbiol [Internet]. 2019;17(3):181-92. Disponible en: https://doi.org/10.1038/s41579-018-0118-9 DOI: 10.1038/s41579-018-0118-9 PMID 30531947 PMCID PMC7097006 Google Académico
Millán-Oñate J, Rodriguez-Morales AJ, Camacho-Moreno G, Mendoza-Ramírez H, Arturo Rodríguez-Sabogal I, Álvarez-Moreno C. A new emerging zoonotic virus of concern: the 2019 novel Coronavirus (COVID-19) [Internet]. Infectio. 24 de febrero de 2020 (3). [citado 5 de abril de 2020]. Disponible en: https://www.revistainfectio.org/index.php/infectio/article/view/848 DOI: 10.22354/IN.V24I3.848 Google Académico
de Wilde AH, Snijder EJ, Kikkert M, van Hemert MJ. Host Factors in Coronavirus Replication. En: Tripp RA, Tompkins SM, editores. Curr Top Microbiol Immunol [Internet]. Cham: Springer International Publishing; 2018. p. 1-42. Disponible en: https://doi.org/10.1007/82_2017_25 DOI: 10.1007/82_2017_25 PMID 28643204 PMCID PMC7119980 Google Académico
de Wit E, van Doremalen N, Falzarano D, Munster VJ. SARS and MERS: recent insights into emerging coronaviruses. Nat Rev Microbiol [Internet]. agosto de 2016;14(8):523-34. Disponible en: https://www.nature.com/articles/nrmicro.2016.81 DOI: 10.1038/nrmicro.2016.81 PMID 27344959 PMCID PMC7097822 Google Académico
Liu Y, Gayle AA, Wilder-Smith A, Rocklöv J. The reproductive number of COVID-19 is higher compared to SARS coronavirus. J Travel Med [Internet]. marzo de 2020;27(2). Disponible en: https://academic.oup.com/jtm/article/27/2/taaa021/5735319 DOI: 10.1093/jtm/taaa021 PMID 32052846 PMCID PMC7074654 Google Académico
Velavan TP, Meyer CG. The COVID-19 epidemic. Trop Med Int Heal [Internet]. marzo de 2020;25(3):278-80. Disponible en: https://onlinelibrary.wiley.com/doi/full/10.1111/tmi.13383 DOI: 10.1111/tmi.13383 PMID 32052514 Google Académico
Valero N, Larreal Y, Mosqueray J, Rincón E. Síndrome Respiratorio Agudo Severo (SRAS): Lecciones y Retos. Invest Clin [Internet]. marzo de 2005;46(1):75-95. Disponible en: https://pubmed.ncbi.nlm.nih.gov/15782539/ PMID 15782539 Google Académico
Bonilla-Aldana DK, Villamil-Gómez WE, Rabaan AA, Rodriguez-Morales AJ. Una nueva zoonosis viral de preocupación global: COVID-19, enfermedad por coronavirus 2019. Iatreia [Internet]. 2020;33(2):107-10. [citado 6 de abril de 2020] Disponible en: https://revistas.udea.edu.co/index.php/iatreia/article/view/341260 Google Académico
Zhang T, Wu Q, Zhang Z. Probable Pangolin Origin of SARS-CoV-2 Associated with the COVID-19 Outbreak. Curr Biol [Internet]. marzo de 2020;30(7):1351.e2. Disponible en: https://www.cell.com/current-biology/pdf/S0960-9822(20)30360-2.pdf?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0960982220303602%3Fshowall%3Dtrue DOI: 10.1016/j.cub.2020.03.022 PMID 32197085 Google Académico
Li G, Fan Y, Lai Y, Han T, Li Z, Zhou P, et al. Coronavirus infections and immune responses. J Med Virol [Internet]. abril de 2020;92(4):424-32. Disponible en: https://onlinelibrary.wiley.com/doi/full/10.1002/jmv.25685 DOI: 10.1002/jmv.25685 PMID 31981224 Google Académico
Zhou P, Yang X-L, Wang X-G, Hu B, Zhang L, Zhang W, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature [Internet]. Marzo de 2020;579(7798):270-3. Disponible en: https://www.nature.com/articles/s41586-020-2012-7 DOI: 10.1038/s41586-020-2012-7 PMID 32015507 PMCID PMC7095418 Google Académico
Richardson P, Griffin I, Tucker C, Smith D, Oechsle O, Phelan A, et al. Baricitinib as potential treatment for 2019-nCoV acute respiratory disease. Lancet [Internet]. Febrero de 2020;395(10223):e30-1. Disponible en: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30304-4/fulltext DOI: 10.1016/S0140-6736(20)30304-4 PMID 32032529 Google Académico
Chen L, Li X, Chen M, Feng Y, Xiong C. The ACE2 expression in human heart indicates new potential mechanism of heart injury among patients infected with SARS-CoV-2. Cardiovasc Res [Internet]. Marzo de 2020 [Publicación en avance]. Disponible en: https://academic.oup.com/cardiovascres/advance-article/doi/10.1093/cvr/cvaa078/5813131 DOI: 10.1093/cvr/cvaa078 PMID 32227090 Google Académico
Center for Diseases Control and Prevention. Symptoms of Coronavirus [Internet]. 2020 [citado 30 de marzo de 2020]. Disponible en: https://www.cdc.gov/coronavirus/2019-ncov/symptoms-testing/symptoms.html?CDC_AA_refVal=https%3A%2F%2Fwww.cdc.gov%2Fcoronavirus%2F2019-ncov%2Fabout%2Fsymptoms.html
Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet [Internet]. Febrero de 2020;395(10223):507-13. Disponible en: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30211-7/fulltext DOI: 10.1016/S0140-6736(20)30211-7 PMID 32007143 PMCID PMC7135076 Google Académico
Holshue ML, DeBolt C, Lindquist S, Lofy KH, Wiesman J, Bruce H, et al. First Case of 2019 Novel Coronavirus in the United States. N Engl J Med [Internet]. Marzo de 2020;382(10):929-36. Disponible en: https://www.nejm.org/doi/full/10.1056/NEJMoa2001191?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed DOI: 10.1056/NEJMoa2001191 PMID 32004427 PMCID PMC7092802 Google Académico
Sinha IP, Harwood R, Semple MG, Hawcutt DB, Thursfield R, Narayan O, et al. COVID-19 infection in children. Lancet Respir Med [Internet]. Marzo de 2020 [Publicación en avance]. Disponible en: https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(20)30152-1/fulltext DOI: 10.1016/S2213-2600(20)30152-1 PMID 32224304 Google Académico
Yang X, Yu Y, Xu J, Shu H, Xia J, Liu H, et al. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. Lancet Respir Med [Internet]. Febrero de 2020[Publicación en avance]. Disponible en: https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(20)30079-5/fulltext DOI: 10.1016/S2213-2600(20)30079-5 PMID 32105632 PMCID PMC7102538 Google Académico
Tian Y, Rong L, Nian W, He Y. Review article: gastrointestinal features in COVID-19 and the possibility of faecal transmission. Aliment Pharmacol Ther [Internet]. Marzo de 2020 [Publicación en avance]. Disponible en: https://onlinelibrary.wiley.com/doi/full/10.1111/apt.15731 DOI: 10.1111/apt.15731 PMID 32222988 Google Académico
Qin C, Zhou L, Hu Z, Zhang S, Yang S, Tao Y, et al. Dysregulation of immune response in patients with COVID-19 in Wuhan, China. Clin Infect Dis [Internet]. Marzo de 2020 [Publicación en avance]. Disponible en: https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciaa248/5803306 DOI: 10.1093/cid/ciaa248 PMID 32161940 PMCID PMC7108125 Google Académico
Sarzi-Puttini P, Giorgi V, Sirotti S, Marotto D, Ardizzone S, Rizzardini G, et al. COVID-19, cytokines and immunosuppression: what can we learn from severe acute respiratory syndrome? Clin Exp Rheumatol [Internet]. 2020;38(2):337-42. Disponible en: https://www.clinexprheumatol.org/abstract.asp?a=15518 PMID 32202240 Google Académico
Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al. A Novel Coronavirus from Patients with Pneumonia in China, 2019. N Engl J Med [Internet]. Febrero de 2020;382(8):727-33. Disponible en: https://www.nejm.org/doi/10.1056/NEJMoa2001017?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200www.ncbi.nlm.nih.gov DOI: 10.1056/NEJMoa2001017 PMID 31978945 PMCID PMC7092803 Google Académico
Center for Diseases Control and Prevention. How Coronavirus Spreads [Internet]. 2020 [citado 6 de abril de 2020]. Disponible en: https://www.cdc.gov/coronavirus/2019-ncov/prevent-getting-sick/how-covid-spreads.html?CDC_AA_refVal=https%3A%2F%2Fwww.cdc.gov%2Fcoronavirus%2F2019-ncov%2Fprepare%2Ftransmission.html
Phan LT, Nguyen T V, Luong QC, Nguyen T V, Nguyen HT, Le HQ, et al. Importation and Human-to-Human Transmission of a Novel Coronavirus in Vietnam. N Engl J Med [Internet]. Febrero de 2020;382(9):872-4. Disponible en: https://www.nejm.org/doi/full/10.1056/NEJMc2001272?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed DOI: 10.1056/NEJMc2001272 PMID 31991079 PMCID PMC7121428 Google Académico
van Doremalen N, Bushmaker T, Morris DH, Holbrook MG, Gamble A, Williamson BN, etal. Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1. N Engl J Med [Internet]. Marzo de 2020 [Publicación en avance]. Disponible en: https://www.nejm.org/doi/full/10.1056/NEJMc2004973?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed DOI: 10.1056/NEJMc2004973 PMID 32182409 PMCID PMC7121658 Google Académico
Chan AKM, Nickson CP, Rudolph JW, Lee A, Joynt GM. Social media for rapid knowledge dissemination: early experience from the COVID-19 pandemic. Anaesthesia [Internet]. Marzo de 2020 [Publicación en avance]. Disponible en: https://onlinelibrary.wiley.com/doi/full/10.1111/anae.15057 DOI: 10.1111/anae.15057 PMID 32227594 Google Académico
Lo IL, Lio CF, Cheong HH, Lei CI, Cheong TH, Zhong X, et al. Evaluation of SARS-CoV-2 RNA shedding in clinical specimens and clinical characteristics of 10 patients with COVID-19 in Macau. Int J Biol Sci [Internet]. 2020;16(10):1698-707. Disponible en: https://www.ijbs.com/v16p1698.htm DOI: 10.7150/ijbs.45357 PMID 32226287 PMCID PMC7098032 Google Académico
Song Z, Xu Y, Bao L, Zhang L, Yu P, Qu Y, et al. From SARS to MERS, Thrusting Coronaviruses into the Spotlight. Viruses [Internet]. Enero de 2019;11(1). Disponible en: https://www.mdpi.com/1999-4915/11/1/59 DOI: 10.3390/v11010059 PMID 30646565 PMCID PMC6357155 Google Académico
Luo C, Yao L, Zhang L, Yao M, Chen X, Wang Q, et al. Possible Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in a Public Bath Center in Huai’an, Jiangsu Province, China. JAMA Netw Open [Internet]. Marzo de 2020;3(3):e204583. Disponible en: https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2763473 DOI: 10.1001/jamanetworkopen.2020.4583 PMID 32227177 Google Académico
Chen S, Liao E, Shao Y. Clinical analysis of pregnant women with 2019 novel coronavirus pneumonia. J Med Virol [Internet]. Marzo de 2020; Disponible en: https://onlinelibrary.wiley.com/doi/abs/10.1002/jmv.25789 DOI: 10.1002/jmv.25789 PMID 32222119 Google Académico
World Health Organization. Laboratory testing for coronavirus disease 2019 (COVID-19) in suspected human cases: interim guidance, 2 March 2020 [Internet]. Geneva:World Health Organization. Disponible en: https://apps.who.int/iris/handle/10665/331329 Google Académico
Chan JF-W, Yuan S, Kok K-H, To KK-W, Chu H, Yang J, et al. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet [Internet]. 15 de febrero de 2020;395(10223):514-23. Disponible en: https://doi.org/10.1016/S0140-6736(20)30154-9 DOI: 10.1016/S0140-6736(20)30154-9 PMID 31986261 Google Académico
Corman VM, Landt O, Kaiser M, Molenkamp R, Meijer A, Chu DKW, et al. Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR. Eurosurveillance [Internet]. 2020;25(3):2000045. Disponible en: https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2020.25.3.2000045 DOI: 10.2807/1560-7917.ES.2020.25.3.2000045 PMID 31992387 PMCID PMC6988269 Google Académico
Lescure F-X, Bouadma L, Nguyen D, Parisey M, Wicky P-H, Behillil S, et al. Clinical and virological data of the first cases of COVID-19 in Europe: a case series. Lancet Infect Dis [Internet]. 2020; Disponible en: https://doi.org/10.1016/S1473-3099(20)30200-0 DOI: 10.1016/S1473-3099(20)30200-0 PMID 32224310 Google Académico
Center for Diseases Control and Prevention. How to Protect Yourself & Others [Internet]. 2020 [citado 30 de marzo de 2020]. Disponible en: https://www.cdc.gov/coronavirus/2019-ncov/prevent-getting-sick/prevention.html?CDC_AA_refVal=https%3A%2F%2Fwww.cdc.gov%2Fcoronavirus%2F2019-ncov%2Fprepare%2Fprevention.html
Sheahan TP, Sims AC, Leist SR, Schäfer A, Won J, Brown AJ, et al. Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV. Nat Commun [Internet]. 2020;11(1):222. Disponible en: https://doi.org/10.1038/s41467-019-13940-6 DOI: 10.1038/s41467-019-13940-6 PMID 31924756 PMCID PMC6954302 Google Académico
Zhang C, Huang S, Zheng F, Dai Y. Controversial treatments: an updated understanding of the Coronavirus Disease 2019. J Med Virol [Internet]. 26 de marzo de 2020 [Publicación en avance]. Disponible en: https://doi.org/10.1002/jmv.25788 DOI: 10.1002/jmv.25788 PMID 32219882 Google Académico
Zhou G, Zhao Q. Perspectives on therapeutic neutralizing antibodies against the Novel Coronavirus SARS-CoV-2. Int J Biol Sci [Internet]. 2020;16(10):1718-23. Disponible en: http://www.ijbs.com/v16p1718.htm DOI: 10.7150/ijbs.45123 PMID 32226289 PMCID PMC7098029 Google Académico
Lurie N, Saville M, Hatchett R, Halton J. Developing Covid-19 Vaccines at Pandemic Speed. N Engl J Med [Internet]. 30 de marzo de 2020 [Publicación en avance]. Disponible en: https://doi.org/10.1056/NEJMp2005630 DOI: 10.1056/NEJMp2005630 PMID 32227757 Google Académico
Dhama K, Sharun K, Tiwari R, Dadar M, Malik YS, Singh KP, et al. COVID-19, an emerging coronavirus infection: advances and prospects in designing and developing vaccines, immunotherapeutics, and therapeutics. Hum Vaccin Immunother [Internet]. 18 de marzo de 2020; [Publicación en avance]. Disponible en: https://doi.org/10.1080/21645515.2020.1735227 DOI: 10.1080/21645515.2020.1735227 PMID 32186952 PMCID PMC7103671 Google Académico
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