Invest Clin 65(2): 206 - 219, 2024 https://doi.org/10.54817/IC.v65n2a07
Corresponding author: Min Zhu. Department of Pharmacy, The Affiliated Taizhou People’s Hospital of Nanjing Medical
University, Taizhou Jiangsu, China.E-mail: zhumin2023@sina.com
The effectiveness of personalized medication
based on drug-related genes, for schizophre-
nia patients with resistance to traditional
drugs.
Shujun Zhou
1#
, Guangqin Zhang
2#
, Zhe Wang
3
, Long Wei
1
, Min Zhu
4
, Jinquan He
5
1
Department of Pharmacy，Nanjing Gaochun People’s Hospital，Nanjing, Jiangsu,
China.
2
Department of Pharmacy, Ezhou Central Hospital, Ezhou, Hubei, China.
3
Department of Pharmacy，Medical Supplies Center of PLA General Hospital，Beijing,
China.
4
Department of Pharmacy，The Affiliated Taizhou People’s Hospital of Nanjing Medical
University，Taizhou Jiangsu，China.
5
Department of Psychosomatic Medicine, Chenzhou First People’s Hospital, Chenzhou,
Hunan, China.
#
They contributed equally to this work.
Keywords: inflammatory cytokines; neurotrophic factors; PANSS; BPRS; social skills;
ADL; CYP2D6.
Abstract. We aimed to study the impact of personalized medication based
on drug-related genes for schizophrenia patients with resistance to traditional
drugs. One hundred and ten schizophrenia patients who sought treatment at
our medical facility between June 2021 and February 2023 were chosen and
divided at random into two groups: one group (n=55) received conventional
medication, while the other group (n=55) received personalized medication
based on their genetic profile. The study compared the levels of inflammatory
cytokines and neurotrophic factors, as well as the scores on the Positive and
Negative Symptoms Scale (PANSS), Brief Psychiatry Rating Scale (BPRS), So-
cial Skills Psychometric Instruments (SSPI), and Ability of Daily Living Scale
(ADL) between the two groups. Following the treatment, both groups exhibited
reduced levels of TNF-α and IL-1β compared to pre-treatment levels, with the
gene-guided group showing even lower levels (p<0.05). Conversely, the levels of
NGF and BDNF increased in both groups post-treatment, with the gene-guided
group demonstrating even higher levels (p<0.05). Additionally, the PANSS and
BPRS scores decreased in both groups after treatment, with the gene-guided
group showing even lower scores (p<0.05). On the other hand, both groups’