Abordaje quirúrgico de los tumores neuroendocrinos pancreáticos

Surgical approach to Pancreatic Neuroendocrine Tumors

Palabras clave: páncreas, tumor neuroendocrino, pancreatectomía, tumores gastroenteropancreaticos

Resumen

Los tumores neuroendocrinos (TNEs) constituyen un grupo heterogéneo de neoplasias que se originan a partir de células neuroendocrinas. Son tumores poco frecuentes con un índice de detección estimado < 1/100,000 individuos, lo que corresponde al 1-2% de las neoplasias pancreáticas. La mayoría de los TNEP son esporádicos, pero estos pueden estar asociados a síndromes hereditarios, incluyendo la neoplasia endocrina múltiple de tipo 1 (NEM-1), el síndrome de Von Hippel Lindau, neurofibromatosis de tipo I y la esclerosis tuberosa. Entre 50 y 75 % de los tumores neuroendocrinos de páncreas pueden no ser funcionales y suelen tener una presentación tardía con síntomas inespecíficos. Tienen un comportamiento biológico menos agresivo que otras neoplasias pancreáticas, como el adenocarcinoma ductal; sin embargo, tienen un pronóstico menos favorable que los otros tumores neuroendocrinos del sistema  gastrointestinal. Se clasifican según el tipo histológico en 3 categorías, y según la producción de sustancias biológicamente activas en funcionantes y no funcionantes. El mejor tratamiento es la cirugía, siempre que el tumor sea resecable y es fundamental el diagnostico preoperatorio de la ubicación de la lesión mediante los estudios de imágenes para determinar el tipo de cirugía y el pronóstico del paciente.

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Biografía del autor/a

Adel Al Awad Jibara, Universidad de Zulia, Venezuela. Maracaibo, Venezuela

Escuela de Medicina. Facultad de Medicina, Universidad de Zulia, Venezuela. Maracaibo, Venezuela

Alfredo José Ramírez, Universidad de los Andes. Mérida, Venezuela.

Facultad de Medicina. Universidad de los Andes. Mérida, Venezuela.

Vianny G. Valera García, Hospital General de Cabimas Dr. Adolfo D ́Empaire, Cabimas, Venezuela.

Hospital General de Cabimas Dr. Adolfo D ́Empaire, Cabimas, Venezuela.

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Publicado
2022-10-25
Cómo citar
Al Awad Jibara, A., Ramírez, A. J., & Valera García, V. G. (2022). Abordaje quirúrgico de los tumores neuroendocrinos pancreáticos: Surgical approach to Pancreatic Neuroendocrine Tumors. Revista Profesional HígadoSano, (24), 32-46. https://doi.org/10.5281/zenodo.7249913
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