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Local Bovine Amniotic Fluid and osseointegration / Istek et al. ______________________________________________________________________
INTRODUCTION
in the amniotic cavity, and it allows the fetus to grow and move freely in
the womb, softening sudden impacts or movements, protecting it from
mother and fetus [1
relative amounts can change during pregnancy [
carbohydrates, fats, amino acids, enzymes, hormones, and pigments
[3
mesenchymal cells [
[
play an important role in human embryo growth and development [6].
studies in humans [, 8].
Bos taurus
].
l concern.
connection between bone tissue and the implant surface. The use of
titanium endosseous dental implants in the rehabilitation of partially
or fully edentulous patients is an alternative for restoring function and
aesthetics [10
after implantation [11, ]. Therefore, given the large number of titanium
millions of failure cases [13
implants, studies have been carried out to accelerate osseointegration
with different technologies and manufacturing methods [
this ambition, studies have reported that hormone replacement therapy,
bisphosphonates, and intermittent administration of parathormone
ects [10].
supplementation and hormone replacement, have been reported
to improve the success and survival rates of dental implants [].
and melatonin supplementation on the osseointegration of implants
have found promising results in animal models, but more research is
needed to evaluate their effectiveness in human [16, ].
factors, on bone healing and bone implant fusion.
MATERIALS AND METHODS
Animals and study design
ing rooms.
used. The cleaning process was completed by autoclave.
Rattus norvegicus
of the study, vaginal smears were performed, and rats in the same
were installed in each rat with no additional treatment.
analysis after decalc
Collection of bovine amniotic uid (BAF)
being allowed to dissolve at room temperature f
Surgical procedures
the corticocancellous bone of the tibial metaphysis. Meanwhile, a
length titanium implants were then inserted through the locating region.
the rats.
Histomorphometric measurements
full anesthesia. The tibias were dissected, and the implants were