Leishmanicidal activity of alkaloids from Hamelia patens

  • Alírica Suárez Universidad Central de Venezuela
  • Beth Diaz Universidad Central de Venezuela
  • Stephen Tillett Universidad Central de Venezuela
  • Elizabeth Valdivieso Universidad Central de Venezuela
  • Reinaldo Compagnone Universidad Central de Venezuela
Palabras clave: rubiaceae, Hamelia patens, leishmanicidal, alkaloids, flavonoids

Resumen

The crude ethanolic extract from the leaves of Hamelia patens Jacq. was active in vitro against Leishmania mexicana. Partition of the extract, showed that the activity was confined to the dichloromethane extract. The four alkaloids isolated from this extract: isopteropodine (1), palmirine (2), rumberine (3) and mitrajavine (4) were evaluated in vitro for antileishmanial activity. Palmirine (2), one of the main alkaloids, showed the highest leishmanicidal activity with IC50= 56 µM, the alkaloid mitrajavine (4) and the two flavonoids isolated from the ethyl acetate extract: kaempferol-3-O-rutinoside (5), and (-) epicatechine (6) are reported for the first time in this plant.

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Publicado
2011-05-12
Cómo citar
Suárez, A., Diaz, B., Tillett, S., Valdivieso, E., & Compagnone, R. (2011). Leishmanicidal activity of alkaloids from Hamelia patens. Ciencia, 16(2). Recuperado a partir de https://produccioncientificaluz.org/index.php/ciencia/article/view/9845
Número
Vol. 16 Núm. 2
Sección
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