Detection of prefrontal lobe blood flow changes in patients with obsessivecompulsive disorder during a verbal fluency task by near-infrared reflectance spectroscopy. / Detección de cambios en el flujo sanguíneo del lóbulo prefrontal en pacientes con trastorno obsesivo-compulsivo, durante una tarea de fluidez verbal, mediante espectroscopia de reflectancia en el infrarrojo cercano.

Hong-Ying Yin, Fan Jiang, Qi-Hua Peng, Yu-Ling Wu

Resumen


Abstract.

The purpose of this work was to use near-infrared reflectance spectroscopy (NIRS) to investigate the spectral characteristics and frontal lobe activation in patients with obsessive-compulsive disorder (OCD) during a verbal fluency task. Thirty-seven patients with OCD, who met the diagnostic criteria of International Classification of Diseases 10 (ICD-10), were recruited. The total score of the Symptom Checklist (SCL-90, grade 1-5) was ≥160 points. The total score of the Yale-Brown Obsessive Compulsive Scale was ≥7 points. The changes in frontal lobe blood flow were measured by NIRS when completing a verbal fluency task. Then, the differences between obsessive-compulsive thoughts and obsessive-compulsive behaviors in OCD, and the concentration variation of oxygenate hemoglobin (Oxy-Hb) and deoxygenate hemoglobin (Deoxy-Hb) were investigated. The difference was significant (P<0.03) between obsessive-compulsive behaviors and obsessive-compulsive thoughts. Obsessive-compulsive behaviors were positively correlated (P<0.01, P<0.05) with depression, anxiety, psychosis and other factors in the SCL-90, and significantly positively correlated (P<0.01, P<0.03) with somatization, hostility and paranoid factor scores in the SCL-90. There was also a trend of partial overlap between the waveform and task period, and the difference was significant (P<0.01) between these. Obsessive-compulsive thoughts were negatively correlated (P<0.05) with channels 9 and 19. The NIRS monitoring spectrum for patients with OCD has certain spectral characteristics of schizophrenia, but there is a repetitive trend between the recovery period and the task period.

Resumen.

El propósito del presente trabajo fue utilizar la espectroscopia de reflectancia en el infrarrojo cercano (NIRS) para investigar las características espectrales y la activación del lóbulo frontal en el trastorno obsesivo compulsivo (TOC) durante una tarea de fluidez verbal. Se reclutaron 37 pacientes con TOC que cumplían los criterios de diagnóstico de la Clasificación Internacional de Enfermedades 10 (CIE-10). La puntuación total de la Lista de Verificación de Síntomas (SCL-90, grado 1-5) fue de 160 puntos. La puntuación total de la Escala Obsesiva-Compulsiva de Yale-Brown fue de ≥7 puntos. Los cambios en el flujo sanguíneo del lóbulo frontal fueron medidos por NIRS al completar la tarea de fluidez verbal. Entonces, se investigaron las diferencias entre los pensamientos obsesivo-compulsivos y los comportamientos obsesivo-compulsivos en TOC, y la variación de las concentraciones de hemoglobina oxigenada (Oxy-Hb) y hemoglobina desoxigenada (Deoxy-Hb). La diferencia fue significativa (P<0,03) entre los comportamientos obsesivo-compulsivos y los pensamientos obsesivo-compulsivos. Los comportamientos obsesivo-compulsivos se correlacionaron positivamente (P<0,01, P<0,05) con depresión, ansiedad, psicosis y otros factores en el SCL-90, y se correlacionaron positivamente de manera significativa (P<0,01, P<0,03) con la somatización, hostilidad y puntuaciones de factor paranoico en el SCL-90. También hubo una tendencia de superposición parcial entre la forma de onda y el período de tarea, y la diferencia fue significativa (P<0,01) entre estos. Los pensamientos obsesivo-compulsivos estaban correlacionados negativamente (P<0,05) con los canales 9 y 19. El espectro de monitoreo NIRS para pacientes con TOC tiene ciertas características espectrales de la esquizofrenia, pero hay una tendencia repetitiva entre el período de recuperación y el período de tarea.

 


Palabras clave


near-infrared reflectance spectroscopy; obsessive-compulsive disorder; verbal fluency; oxygenate hemoglobin; deoxygenate hemoglobin; espectroscopía de reflectancia casi infrarroja; trastorno obsesivo compulsivo; fluidez verbal; hemoglobina oxigenada.

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Referencias


Yin L, Zhou J, Chen D, Han T, Zheng B, You- nis A, Shao Q. A review of the application of near infrared spectroscopy to rare traditional Chinese medicine. Spectrochim Acta A Mol Biomol Spectrosc 2019;221:117208.

Rashnavadi T, Macnab A Cheung A, Shad- gan A, Kwon BK, Shadgan B. Monito- ring spinal cord hemodynamics and tissue oxygenation: a review of the literature with special focus on the near-infrared spectros- copy technique. Spinal Cord 2019;57:617- 625.

AlZubaidi AK, Ethawi Y, Schmölzer GM, Sherif S, Narvey M, Seshia M. Review of biomedical applications of contactless imaging of neonates using infrared ther- mography and beyond. Methods Protoc 2018;1(4):39. doi: 10.3390/mps1040039.

Hou L, Liu Y, Qian L, Zheng Y, Gao J, Cao W, Shang Y. Portable near-infrared te- chnologies and devices for noninvasive as- sessment of tissue hemodynamics. J Health Eng 2019;2019:3750495.

Hoshi Y, Tamura M. Dynamic multichan- nel near-infrared optical imaging of human brain activity. J Appl Physiol 1993;75:1842- 1846.

Badurdeen S, Roberts C, Blank D, Miller S, Stojanovska V, Davis P, Hooper S, Pol- glase G. Haemodynamic instability and bra- in injury in neonates exposed to hypoxia-is- chaemia. Brain Sci 2019;9(3): pii E49.

Tinga AM, de Back TT, Louwerse MM. Non-invasive neurophysiological measu- res of learning: a meta-analysis. Neurosci Biobehav Rev 2019;99:59-89.

Andersen AV, Simonsen SA, Schytz HW, Iversen HK. Assessing low-

frequency os- cillations in cerebrovascular diseases and related conditions with near-infrared spec- troscopy: a plausible method for evaluating cerebral autoregulation? Neurophotonics 2018;5:030901.

Akashi H, Tsujii N, Mikawa W, Adachi T, Kirime E, Shirakawa O. Prefrontal cortex activation is associated with a discrepancy beween self-and observer-rated depression severities of major depressive disorder: A multichannel near-infrared spectroscopy study. J Affect Disord 2015;174:165-172.

Herrmann MJ, Ehlis AC, Fallgatter AJ. Frontal activation during a verbal-fluency task as measured by near-infrared spectros- copy. Brain Res Bull 2003;61:51-56.

Henry JD, Crawford JR. A meta-analytic review of verbal fluency performance fo- llowing focal cortical lesions. Neuropsycho- logy 2004;18:284-295.

Kinou M, Takizawa R, Marumo K, Kawa- saki S, Kawakubo Y, Fukuda M, Kasai K. Differential spatiotemporal characteristics of the prefrontal hemodynamic response and their association with functional im- pairment in schizophrenia and major de- pression. Schizophr Res 2013;150:459-467.

Hon SKH, Siu BWM, Cheng CW, Wong WCW, Foa EB. Validation of the Chinese Version of Obsessive-Compulsive Inven- tory-Revised. East Asian Arch Psychiatry 2019;29(4):103-111.

Quan WX, Bai YF, Dong WT, Tian J, Yang SZ. Normal frontotemporal oxygenated he- moglobin level detection by near-infrared imaging. Journal of China Medical Univer- sity 2012;41:1044-1046.

Yin HY, Zhao MS, Jiang HB, Yang LH, Zhong YF. Preliminary Evidences of Ob- sessive Compulsive Disorder as Thinking Disorder. International Conference on E- Commerce and Contemporary Economic Development (ECED 2014) 2014:343-347.

Gregory ST, Kay B, Riemann BC, Good- man WK, Storch EA. Cost-effectiveness of treatment alternatives for treatment refractory pediatric obsessive-compulsive disorder. J Anxiety Disord 2020;69:102151.

Marazziti D, Mucci F, Avella MT, Dell’Oste V, Baroni S, Dell’Osso L. Treatment of the obsessive-compulsive and bipolar disorders comorbidity: pharmacodynamic and phar- macokinetic evaluation. Expert Opin Drug Metab Toxicol 2019;15(8):619-631.

Houghton DC, Stein DJ, Cortese BM. Re- view. Exteroceptive sensory abnormalities in childhood and adolescent anxiety and obsessive-compulsive disorder: A critical re- view. J Am Acad Child Adolesc Psychiatry 2020;59(1):78-87.

Tezenas du Montcel C, Pelissolo A, Schür- hoff F, Pignon B. Obsessive-compulsive symptoms in schizophrenia: an up-to-date review of literature. Curr Psychiatry Rep 2019;21(8):64.

de Boer JN, Vingerhoets C, Hirdes M, McAlonan GM, Amelsvoort TV, Zinkstok JR. Efficacy and tolerability of riluzole in psychiatric disorders: A systematic review and preliminary meta-analysis. Psychiatry Res 2019;278:294-302.




DOI: http://dx.doi.org/10.22209/IC.v61n2a04

Universidad del Zulia / Venezuela / Investigación Clínica /riclinicas@gmail.com / p-ISSN: 0535-5133 / e-ISSN: 2477-9393

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