Association of CCR5 G59029A and RANTES –28 C/G polymorphisms in patients with chronic periodontitis and/or Type 2 Diabetes Mellitus, in a Southeastern Mexican population

  • Victor Manuel Martínez-Aguilar University of Yucatán, Mérida, Yucatán - México.
  • Bertha Arelly Carrillo-Ávila University of Yucatán, Mérida, Yucatán - México.
  • Guadalupe García-Escalante University of Yucatán, Mérida, Yucatán - México.
  • Ligia Vera-Gamboa University of Yucatán, Mérida, Yucatán - México.
  • Diana María Escobar-García Autonomous University of San Luis Potosi. San Luis Potosí - SLP, México.
  • Amaury Pozos-Guillén Autonomous University of San Luis Potosi. San Luis Potosí - SLP, México.
  • Eugenia Guzmán-Marin Autonomous University of Yucatán, Mérida, Yucatan - México.
  • Nina Valadez-González Autonomous University of Yucatán, Mérida, Yucatan - México.
Palabras clave: polymorphism, periodontitis, RANTES, diabetes

Resumen

The aim of this study was to determine the association of poly- morphisms CCR5G59029A and RANTES –28C/G in chronic periodontitis (CP) and type 2 diabetes mellitus (T2D). A case control study was carried out that included 163 patients with CP and/or T2D. A periodontal examination was done on all potential participants in order to diagnose CP. To confirm the diag- nosis of T2D, peripheral blood samples were collected for laboratory analyses (blood glucose and glycosylated hemoglobin). Genotyping was performed by PCR-RFLP. The Genotype AA of CCR5 G59029A increased the risk for CP 7.36 times (95% CI = 1.14–78.27, p = 0.03). This genotype’s A allele also increased T2D risk 2.23 times (95% CI = 1.10–4.54, p = 0.02). Genotype CG of RANTES –28 C/G increased CP risk 5.99 times (95% CI = 1.93–18.57, p = 0.002). Its G allele also raised CP risk 4.55 times (95% CI = 1.58–13.04, p = 0.002). In patients suffering both CP and T2D, the CG genotype was associated with the diseases, increasing their risk 4.68-fold (95% CI = 1.60–14.03, p = 0.004). Its  G allele raised CP and T2D risk 3.8 times (95% CI = 1.35–10.67, p = 0.008). The AA genotype and allele A of G59029A polymorphism of CCR5 gene is a risk factor for CP. The CG genotype and allele G polymorphism RANTES –28 C/G gene are risk factors for CP in the population studied. The CG genotype and G allele polymorphism RANTES –28 C/G showed a strong association and a subse- quent risk factor for the coexistence of CP and T2D

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Biografía del autor/a

Victor Manuel Martínez-Aguilar, University of Yucatán, Mérida, Yucatán - México.

Periodontics Department, Faculty of Dentistry, Autonomous University of Yucatán, Mérida, Yucatán, México.

Bertha Arelly Carrillo-Ávila, University of Yucatán, Mérida, Yucatán - México.
Periodontics Department, Faculty of Dentistry, Autonomous University of Yucatán, Mérida, Yucatán, México.
Guadalupe García-Escalante, University of Yucatán, Mérida, Yucatán - México.

Regional Research Center “Dr. Hideyo Noguchi”. Genetics Laboratory, Autonomous University of Yucatán, Mérida, Yucatan, México.

Ligia Vera-Gamboa, University of Yucatán, Mérida, Yucatán - México.

Regional Research Center “Dr. Hideyo Noguchi”. Hematology Laboratory, Autonomous University of Yucatán, Mérida, Yucatan, México.

Diana María Escobar-García, Autonomous University of San Luis Potosi. San Luis Potosí - SLP, México.

Basic Science Lab, Faculty of Dentistry, Autonomous University of San Luis Potosi. San Luis Potosí, SLP, México.

Amaury Pozos-Guillén, Autonomous University of San Luis Potosi. San Luis Potosí - SLP, México.
Basic Science Lab, Faculty of Dentistry, Autonomous University of San Luis Potosi. San Luis Potosí, SLP, México.
Eugenia Guzmán-Marin, Autonomous University of Yucatán, Mérida, Yucatan - México.

Regional Research Center “Dr. Hideyo Noguchi”. Cell Biology Laboratory, Autonomous University of Yucatán, Mérida, Yucatan, México.

Nina Valadez-González, Autonomous University of Yucatán, Mérida, Yucatan - México.

Regional Research Center “Dr. Hideyo Noguchi”. Hematology Laboratory, Autonomous University of Yucatán, Mérida, Yucatan, México.

Publicado
2018-08-26
Cómo citar
Martínez-Aguilar, V. M., Carrillo-Ávila, B. A., García-Escalante, G., Vera-Gamboa, L., Escobar-García, D. M., Pozos-Guillén, A., Guzmán-Marin, E., & Valadez-González, N. (2018). Association of CCR5 G59029A and RANTES –28 C/G polymorphisms in patients with chronic periodontitis and/or Type 2 Diabetes Mellitus, in a Southeastern Mexican population. Investigación Clínica, 59(2), 135. Recuperado a partir de https://produccioncientificaluz.org/index.php/investigacion/article/view/29097
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Trabajos Originales